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- W3087789132 abstract "Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the health of millions of people in the United States and worldwide. Currently, there are no approved therapies that can halt or reverse the clinical progression of AD. Traditionally, AD is characterized first by the appearance of amyloid-β (Aβ) plaques followed by the formation of intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau (p-tau). These lesions are linked to synapse loss and eventual cognitive impairment. Additionally, microgliosis is consistently found in regions of the brain with AD pathology. The role of microglia in AD onset and progression remains unclear. Several recent reports indicate that the assembly of the multi-protein complex known as the NOD, LRR, and pyrin-domain containing 3 (Nlrp3) inflammasome by microglia results in apoptosis spec-like protein containing a CARD (Asc) spec formation, which then nucleates new Aβ plaques, thus amplifying Aβ-associated pathology. NFTs can also activate the Nlrp3 inflammasome leading to enhanced tau-associated pathology. Here, we will review the role of microglia and the activation of the inflammasome in the innate immune response to AD." @default.
- W3087789132 created "2020-10-01" @default.
- W3087789132 creator A5016691718 @default.
- W3087789132 creator A5090212455 @default.
- W3087789132 date "2020-09-18" @default.
- W3087789132 modified "2023-10-14" @default.
- W3087789132 title "The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease" @default.
- W3087789132 cites W1520447517 @default.
- W3087789132 cites W1741501061 @default.
- W3087789132 cites W1964506812 @default.
- W3087789132 cites W1966679211 @default.
- W3087789132 cites W1976357608 @default.
- W3087789132 cites W1977159891 @default.
- W3087789132 cites W1981893522 @default.
- W3087789132 cites W1991457465 @default.
- W3087789132 cites W1991805788 @default.
- W3087789132 cites W1993976394 @default.
- W3087789132 cites W2011041653 @default.
- W3087789132 cites W2017922747 @default.
- W3087789132 cites W2019495623 @default.
- W3087789132 cites W2033617297 @default.
- W3087789132 cites W2042698977 @default.
- W3087789132 cites W2052895824 @default.
- W3087789132 cites W2055727949 @default.
- W3087789132 cites W2064874359 @default.
- W3087789132 cites W2067406680 @default.
- W3087789132 cites W2071728536 @default.
- W3087789132 cites W2072210142 @default.
- W3087789132 cites W2074899354 @default.
- W3087789132 cites W2078819049 @default.
- W3087789132 cites W2078850432 @default.
- W3087789132 cites W2081262717 @default.
- W3087789132 cites W2082402714 @default.
- W3087789132 cites W2088765886 @default.
- W3087789132 cites W2091564585 @default.
- W3087789132 cites W2099588975 @default.
- W3087789132 cites W2100026237 @default.
- W3087789132 cites W2109421548 @default.
- W3087789132 cites W2113010696 @default.
- W3087789132 cites W2118403357 @default.
- W3087789132 cites W2119098586 @default.
- W3087789132 cites W2120052164 @default.
- W3087789132 cites W2127014397 @default.
- W3087789132 cites W2132573038 @default.
- W3087789132 cites W2133646735 @default.
- W3087789132 cites W2134007048 @default.
- W3087789132 cites W2138554422 @default.
- W3087789132 cites W2148898943 @default.
- W3087789132 cites W2149671708 @default.
- W3087789132 cites W2153328565 @default.
- W3087789132 cites W2155344647 @default.
- W3087789132 cites W2156414024 @default.
- W3087789132 cites W2164222787 @default.
- W3087789132 cites W2175794645 @default.
- W3087789132 cites W2223158988 @default.
- W3087789132 cites W2243723775 @default.
- W3087789132 cites W2254807163 @default.
- W3087789132 cites W2314634699 @default.
- W3087789132 cites W2339534121 @default.
- W3087789132 cites W2346472573 @default.
- W3087789132 cites W2408084759 @default.
- W3087789132 cites W2534771646 @default.
- W3087789132 cites W2554948325 @default.
- W3087789132 cites W2560062133 @default.
- W3087789132 cites W2562786167 @default.
- W3087789132 cites W2587539025 @default.
- W3087789132 cites W2594548297 @default.
- W3087789132 cites W2600946903 @default.
- W3087789132 cites W2743727231 @default.
- W3087789132 cites W2761210275 @default.
- W3087789132 cites W2763928642 @default.
- W3087789132 cites W2766700106 @default.
- W3087789132 cites W2772451653 @default.
- W3087789132 cites W2775627464 @default.
- W3087789132 cites W2777928756 @default.
- W3087789132 cites W2790572647 @default.
- W3087789132 cites W2810072585 @default.
- W3087789132 cites W2886301392 @default.
- W3087789132 cites W2888308014 @default.
- W3087789132 cites W2890670389 @default.
- W3087789132 cites W2890743650 @default.
- W3087789132 cites W2900946639 @default.
- W3087789132 cites W2901800184 @default.
- W3087789132 cites W2902735396 @default.
- W3087789132 cites W2903710086 @default.
- W3087789132 cites W2904483712 @default.
- W3087789132 cites W2904554675 @default.
- W3087789132 cites W2912579052 @default.
- W3087789132 cites W2929404193 @default.
- W3087789132 cites W2941630117 @default.
- W3087789132 cites W2942871539 @default.
- W3087789132 cites W2946298400 @default.
- W3087789132 cites W2951541013 @default.
- W3087789132 cites W2952366162 @default.
- W3087789132 cites W2953373572 @default.
- W3087789132 cites W2954390789 @default.
- W3087789132 cites W2954782052 @default.
- W3087789132 cites W2963281983 @default.
- W3087789132 cites W2964919039 @default.
- W3087789132 cites W2982061867 @default.