Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087871595> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3087871595 endingPage "455" @default.
- W3087871595 startingPage "446" @default.
- W3087871595 abstract "Aim: To assess AB-BEZ235-NP potential as a radio-sensitizer in hepatocellular carcinoma models. Method: By comparing hepatocellular carcinoma cell with simple radiation or combined AB-BEZ235-NP therapy, the HCC apoptosis and self-repair level have significant differences in mortality rates and cell migration abilities. Results: Cell proliferation and DNA damage increased by pretreatment with AB-BEZ235-NP after irradiation; further studies on the repair pathway indicated that AB-BEZ235-NP inhibited the important pathway of DSB repair. Our results further show that AB-BEZ235-NP significantly inhibits the phosphorylation of the canonical protein, γ -H2AX, in the NHEJ DSB repair pathway and Serine Protein Kinase (SPK) ATM, and TP53-Binding Protein one. More importantly, AB-BEZ235-NP increased the mount of mean γ -H2AX Foci in irradiated cells, indicating that AB-BEZ235-NP can selectively inhibit DSB repair in HCC cells. Therefore, these results clearly eludicate that treatment with AB-BEZ235-NP is a potential promising therapy which can increase the radiosensitivity to HCC." @default.
- W3087871595 created "2020-10-01" @default.
- W3087871595 creator A5011690431 @default.
- W3087871595 creator A5014059510 @default.
- W3087871595 creator A5025180804 @default.
- W3087871595 creator A5032070172 @default.
- W3087871595 creator A5045231545 @default.
- W3087871595 creator A5062877958 @default.
- W3087871595 creator A5064783825 @default.
- W3087871595 creator A5066391897 @default.
- W3087871595 creator A5070944377 @default.
- W3087871595 creator A5077900771 @default.
- W3087871595 creator A5079609030 @default.
- W3087871595 creator A5084629646 @default.
- W3087871595 date "2020-04-01" @default.
- W3087871595 modified "2023-10-16" @default.
- W3087871595 title "Anti-GPC3 Antibody-Conjugated BEZ235 Loaded Polymeric Nanoparticles (Ab-BEZ235-NP) Enhances Radiosensitivity in Hepatocellular Carcinoma Cells by Inhibition of DNA Double-Strand Break Repair" @default.
- W3087871595 doi "https://doi.org/10.1166/jbn.2020.2834" @default.
- W3087871595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32970977" @default.
- W3087871595 hasPublicationYear "2020" @default.
- W3087871595 type Work @default.
- W3087871595 sameAs 3087871595 @default.
- W3087871595 citedByCount "3" @default.
- W3087871595 countsByYear W30878715952021 @default.
- W3087871595 countsByYear W30878715952022 @default.
- W3087871595 crossrefType "journal-article" @default.
- W3087871595 hasAuthorship W3087871595A5011690431 @default.
- W3087871595 hasAuthorship W3087871595A5014059510 @default.
- W3087871595 hasAuthorship W3087871595A5025180804 @default.
- W3087871595 hasAuthorship W3087871595A5032070172 @default.
- W3087871595 hasAuthorship W3087871595A5045231545 @default.
- W3087871595 hasAuthorship W3087871595A5062877958 @default.
- W3087871595 hasAuthorship W3087871595A5064783825 @default.
- W3087871595 hasAuthorship W3087871595A5066391897 @default.
- W3087871595 hasAuthorship W3087871595A5070944377 @default.
- W3087871595 hasAuthorship W3087871595A5077900771 @default.
- W3087871595 hasAuthorship W3087871595A5079609030 @default.
- W3087871595 hasAuthorship W3087871595A5084629646 @default.
- W3087871595 hasConcept C126322002 @default.
- W3087871595 hasConcept C134935766 @default.
- W3087871595 hasConcept C143425029 @default.
- W3087871595 hasConcept C1491633281 @default.
- W3087871595 hasConcept C185592680 @default.
- W3087871595 hasConcept C190283241 @default.
- W3087871595 hasConcept C206684579 @default.
- W3087871595 hasConcept C2778019345 @default.
- W3087871595 hasConcept C502942594 @default.
- W3087871595 hasConcept C509974204 @default.
- W3087871595 hasConcept C552990157 @default.
- W3087871595 hasConcept C55493867 @default.
- W3087871595 hasConcept C71924100 @default.
- W3087871595 hasConcept C86803240 @default.
- W3087871595 hasConceptScore W3087871595C126322002 @default.
- W3087871595 hasConceptScore W3087871595C134935766 @default.
- W3087871595 hasConceptScore W3087871595C143425029 @default.
- W3087871595 hasConceptScore W3087871595C1491633281 @default.
- W3087871595 hasConceptScore W3087871595C185592680 @default.
- W3087871595 hasConceptScore W3087871595C190283241 @default.
- W3087871595 hasConceptScore W3087871595C206684579 @default.
- W3087871595 hasConceptScore W3087871595C2778019345 @default.
- W3087871595 hasConceptScore W3087871595C502942594 @default.
- W3087871595 hasConceptScore W3087871595C509974204 @default.
- W3087871595 hasConceptScore W3087871595C552990157 @default.
- W3087871595 hasConceptScore W3087871595C55493867 @default.
- W3087871595 hasConceptScore W3087871595C71924100 @default.
- W3087871595 hasConceptScore W3087871595C86803240 @default.
- W3087871595 hasIssue "4" @default.
- W3087871595 hasLocation W30878715951 @default.
- W3087871595 hasLocation W30878715952 @default.
- W3087871595 hasOpenAccess W3087871595 @default.
- W3087871595 hasPrimaryLocation W30878715951 @default.
- W3087871595 hasRelatedWork W2033795765 @default.
- W3087871595 hasRelatedWork W2059626779 @default.
- W3087871595 hasRelatedWork W2096142079 @default.
- W3087871595 hasRelatedWork W2097372335 @default.
- W3087871595 hasRelatedWork W2415398623 @default.
- W3087871595 hasRelatedWork W2514738721 @default.
- W3087871595 hasRelatedWork W2774282247 @default.
- W3087871595 hasRelatedWork W2993427936 @default.
- W3087871595 hasRelatedWork W4225838180 @default.
- W3087871595 hasRelatedWork W4303621977 @default.
- W3087871595 hasVolume "16" @default.
- W3087871595 isParatext "false" @default.
- W3087871595 isRetracted "false" @default.
- W3087871595 magId "3087871595" @default.
- W3087871595 workType "article" @default.