FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087908551> ?p ?o ?g. }

• W3087908551 abstract "ABSTRACT CD8 + T cells are inherently cross-reactive and recognize numerous peptide antigens in the context of a given major histocompatibility complex class I (MHCI) molecule via the clonotypically expressed T cell receptor (TCR). The lineally expressed coreceptor CD8 interacts coordinately with MHCI at a distinct and largely invariant site to slow the TCR/peptide-MHCI (pMHCI) dissociation rate and enhance antigen sensitivity. However, this biological effect is not necessarily uniform, and theoretical models suggest that antigen sensitivity can be modulated in a differential manner by CD8. We used an intrinsically controlled system to determine how the relationship between the TCR/pMHCI interaction and the pMHCI/CD8 interaction affects the functional sensitivity of antigen recognition. Our data show that modulation of the pMHCI/CD8 interaction can reorder the agonist hierarchy of peptide ligands across a spectrum of affinities for the TCR. SIGNIFICANCE Sufficient immune coverage of the peptide universe within a finite host requires highly degenerate T cell receptors (TCRs). However, this inherent need for antigen cross-recognition is associated with a high risk of autoimmunity, which can only be mitigated by a process of adaptable specificity. We describe a mechanism that resolves this conundrum by allowing individual clonotypes to focus on specific peptide ligands without alterations to the structure of the TCR." @default.
• W3087908551 created "2020-10-01" @default.
• W3087908551 creator A5005062979 @default.
• W3087908551 creator A5014326442 @default.
• W3087908551 creator A5046316209 @default.
• W3087908551 creator A5049518622 @default.
• W3087908551 creator A5049532502 @default.
• W3087908551 creator A5049685474 @default.
• W3087908551 creator A5050162207 @default.
• W3087908551 creator A5062917617 @default.
• W3087908551 creator A5064981646 @default.
• W3087908551 creator A5068766881 @default.
• W3087908551 creator A5075518122 @default.
• W3087908551 creator A5078682100 @default.
• W3087908551 creator A5086090152 @default.
• W3087908551 date "2020-09-23" @default.
• W3087908551 modified "2023-10-16" @default.
• W3087908551 title "CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor" @default.
• W3087908551 cites W1512812674 @default.
• W3087908551 cites W1612041908 @default.
• W3087908551 cites W1964115378 @default.
• W3087908551 cites W1968112727 @default.
• W3087908551 cites W1986216579 @default.
• W3087908551 cites W1989199118 @default.
• W3087908551 cites W1990328636 @default.
• W3087908551 cites W1991693947 @default.
• W3087908551 cites W1992703130 @default.
• W3087908551 cites W2006478036 @default.
• W3087908551 cites W2036458764 @default.
• W3087908551 cites W2049204549 @default.
• W3087908551 cites W2065430316 @default.
• W3087908551 cites W2065635440 @default.
• W3087908551 cites W2073228254 @default.
• W3087908551 cites W2077884399 @default.
• W3087908551 cites W2082794963 @default.
• W3087908551 cites W2086831735 @default.
• W3087908551 cites W2091256934 @default.
• W3087908551 cites W2094213517 @default.
• W3087908551 cites W2111536196 @default.
• W3087908551 cites W2115659551 @default.
• W3087908551 cites W2127108195 @default.
• W3087908551 cites W2132776501 @default.
• W3087908551 cites W2137739349 @default.
• W3087908551 cites W2142845598 @default.
• W3087908551 cites W2146040535 @default.
• W3087908551 cites W2146074801 @default.
• W3087908551 cites W2157384708 @default.
• W3087908551 cites W2160934060 @default.
• W3087908551 cites W2166313015 @default.
• W3087908551 cites W2171868381 @default.
• W3087908551 cites W2523125170 @default.
• W3087908551 cites W2558508376 @default.
• W3087908551 cites W2762980752 @default.
• W3087908551 cites W4229956965 @default.
• W3087908551 doi "https://doi.org/10.1101/2020.09.23.310375" @default.
• W3087908551 hasPublicationYear "2020" @default.
• W3087908551 type Work @default.
• W3087908551 sameAs 3087908551 @default.
• W3087908551 citedByCount "0" @default.
• W3087908551 crossrefType "posted-content" @default.
• W3087908551 hasAuthorship W3087908551A5005062979 @default.
• W3087908551 hasAuthorship W3087908551A5014326442 @default.
• W3087908551 hasAuthorship W3087908551A5046316209 @default.
• W3087908551 hasAuthorship W3087908551A5049518622 @default.
• W3087908551 hasAuthorship W3087908551A5049532502 @default.
• W3087908551 hasAuthorship W3087908551A5049685474 @default.
• W3087908551 hasAuthorship W3087908551A5050162207 @default.
• W3087908551 hasAuthorship W3087908551A5062917617 @default.
• W3087908551 hasAuthorship W3087908551A5064981646 @default.
• W3087908551 hasAuthorship W3087908551A5068766881 @default.
• W3087908551 hasAuthorship W3087908551A5075518122 @default.
• W3087908551 hasAuthorship W3087908551A5078682100 @default.
• W3087908551 hasAuthorship W3087908551A5086090152 @default.
• W3087908551 hasBestOaLocation W30879085511 @default.
• W3087908551 hasConcept C147483822 @default.
• W3087908551 hasConcept C154317977 @default.
• W3087908551 hasConcept C167672396 @default.
• W3087908551 hasConcept C170493617 @default.
• W3087908551 hasConcept C19317047 @default.
• W3087908551 hasConcept C202751555 @default.
• W3087908551 hasConcept C203014093 @default.
• W3087908551 hasConcept C207936829 @default.
• W3087908551 hasConcept C2776090121 @default.
• W3087908551 hasConcept C2778938600 @default.
• W3087908551 hasConcept C2779281246 @default.
• W3087908551 hasConcept C54355233 @default.
• W3087908551 hasConcept C55493867 @default.
• W3087908551 hasConcept C70721500 @default.
• W3087908551 hasConcept C86803240 @default.
• W3087908551 hasConcept C8891405 @default.
• W3087908551 hasConcept C95444343 @default.
• W3087908551 hasConceptScore W3087908551C147483822 @default.
• W3087908551 hasConceptScore W3087908551C154317977 @default.
• W3087908551 hasConceptScore W3087908551C167672396 @default.
• W3087908551 hasConceptScore W3087908551C170493617 @default.
• W3087908551 hasConceptScore W3087908551C19317047 @default.
• W3087908551 hasConceptScore W3087908551C202751555 @default.
• W3087908551 hasConceptScore W3087908551C203014093 @default.
• W3087908551 hasConceptScore W3087908551C207936829 @default.
• W3087908551 hasConceptScore W3087908551C2776090121 @default.

• next