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- W3087914903 abstract "• Enantioselective biotransformation of several aliphatic diketones. • Even bulky molecules containing a phenyl moiety are accepted. • Reaction parameter adjustment directs the product outcome. • BlBDH shows high maximum reaction rates for unphysiological substrates. The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso -butanediol dehydrogenase from Bacillus licheniformis DSM 13 T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli . BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled." @default.
- W3087914903 created "2020-10-01" @default.
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- W3087914903 date "2020-12-01" @default.
- W3087914903 modified "2023-09-27" @default.
- W3087914903 title "Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2,3-diol dehydrogenase" @default.
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- W3087914903 doi "https://doi.org/10.1016/j.jbiotec.2020.09.016" @default.
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