Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087930831> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W3087930831 endingPage "252" @default.
- W3087930831 startingPage "251" @default.
- W3087930831 abstract "Mitral Valve Prolapse (MVP) affects 3% of the population and is characterized by a heterogeneous mitral leaflet remodeling. The pathophysiological mechanisms involved in MVP development are not fully understood, the only therapeutic option remains the surgical valve replacement. The first mutation causing MVP has been recently identified on the FLNA gene. The generation of a unique knock-in (KI) rat model for the FLNA-P637Q mutation paves the road to study the molecular mechanisms involved in MVP development. The aim of our study was to characterize the functional, morphological and molecular expression of the valvular disease in our unique KI rat model. 5 wild-type (WT) and 10 KI rats were evaluated at 3, 6 and 26 weeks. Comprehensive 2D echocardiography was performed to determine valve function and morphology. 3D quantitative analysis of the mitral valve (MV) remodelling was done using micro-tomodensitometry (microCT). MV tissue composition was analysed based on histological and immunohistochemistry. Based on the qualitative echocardiographic assessment of the valve, a high genotype-phenotype concordance was observed (100%, 93% and 100% for each time points). The anterior leaflet was longer in KI comparatively to WT rats (+ 12 to + 14% increase at all time points P < 0.01). Using microCT analysis, we confirmed the larger 3D MV volume in KI compared to WT (+ 20 to + 58%; all time points P < 0.05). Histological and immunohistological analyses pointed out towards a myxomatous valve disease (leaflet's thickening, hypercellularity, proteoglycans accumulation without calcification). Our results attest for the presence of a myxomatous MV dystrophy in the KI rat model comparable to the one described in MVP patients. These findings confirm this unique model is pertinent for the study of pathophysiological molecular mechanisms associated with MVP development and offers a new opportunity to identify potential therapeutic targets." @default.
- W3087930831 created "2020-10-01" @default.
- W3087930831 creator A5000338304 @default.
- W3087930831 creator A5025151077 @default.
- W3087930831 creator A5026485054 @default.
- W3087930831 creator A5031579548 @default.
- W3087930831 creator A5039379911 @default.
- W3087930831 creator A5054655784 @default.
- W3087930831 creator A5065006567 @default.
- W3087930831 creator A5071374620 @default.
- W3087930831 creator A5071896100 @default.
- W3087930831 creator A5086542243 @default.
- W3087930831 creator A5089581017 @default.
- W3087930831 date "2020-10-01" @default.
- W3087930831 modified "2023-10-17" @default.
- W3087930831 title "Functional, structural and molecular characterization of a new mitral valve prolapse animal model: The FLNA-P637Q KI rat" @default.
- W3087930831 doi "https://doi.org/10.1016/j.acvdsp.2020.03.126" @default.
- W3087930831 hasPublicationYear "2020" @default.
- W3087930831 type Work @default.
- W3087930831 sameAs 3087930831 @default.
- W3087930831 citedByCount "0" @default.
- W3087930831 crossrefType "journal-article" @default.
- W3087930831 hasAuthorship W3087930831A5000338304 @default.
- W3087930831 hasAuthorship W3087930831A5025151077 @default.
- W3087930831 hasAuthorship W3087930831A5026485054 @default.
- W3087930831 hasAuthorship W3087930831A5031579548 @default.
- W3087930831 hasAuthorship W3087930831A5039379911 @default.
- W3087930831 hasAuthorship W3087930831A5054655784 @default.
- W3087930831 hasAuthorship W3087930831A5065006567 @default.
- W3087930831 hasAuthorship W3087930831A5071374620 @default.
- W3087930831 hasAuthorship W3087930831A5071896100 @default.
- W3087930831 hasAuthorship W3087930831A5086542243 @default.
- W3087930831 hasAuthorship W3087930831A5089581017 @default.
- W3087930831 hasConcept C10162356 @default.
- W3087930831 hasConcept C104317684 @default.
- W3087930831 hasConcept C126322002 @default.
- W3087930831 hasConcept C127716648 @default.
- W3087930831 hasConcept C142724271 @default.
- W3087930831 hasConcept C164705383 @default.
- W3087930831 hasConcept C204232928 @default.
- W3087930831 hasConcept C2777543888 @default.
- W3087930831 hasConcept C2780309369 @default.
- W3087930831 hasConcept C2781030672 @default.
- W3087930831 hasConcept C2908647359 @default.
- W3087930831 hasConcept C54355233 @default.
- W3087930831 hasConcept C71924100 @default.
- W3087930831 hasConcept C86803240 @default.
- W3087930831 hasConcept C99454951 @default.
- W3087930831 hasConceptScore W3087930831C10162356 @default.
- W3087930831 hasConceptScore W3087930831C104317684 @default.
- W3087930831 hasConceptScore W3087930831C126322002 @default.
- W3087930831 hasConceptScore W3087930831C127716648 @default.
- W3087930831 hasConceptScore W3087930831C142724271 @default.
- W3087930831 hasConceptScore W3087930831C164705383 @default.
- W3087930831 hasConceptScore W3087930831C204232928 @default.
- W3087930831 hasConceptScore W3087930831C2777543888 @default.
- W3087930831 hasConceptScore W3087930831C2780309369 @default.
- W3087930831 hasConceptScore W3087930831C2781030672 @default.
- W3087930831 hasConceptScore W3087930831C2908647359 @default.
- W3087930831 hasConceptScore W3087930831C54355233 @default.
- W3087930831 hasConceptScore W3087930831C71924100 @default.
- W3087930831 hasConceptScore W3087930831C86803240 @default.
- W3087930831 hasConceptScore W3087930831C99454951 @default.
- W3087930831 hasIssue "2-4" @default.
- W3087930831 hasLocation W30879308311 @default.
- W3087930831 hasOpenAccess W3087930831 @default.
- W3087930831 hasPrimaryLocation W30879308311 @default.
- W3087930831 hasRelatedWork W1518603627 @default.
- W3087930831 hasRelatedWork W2034738555 @default.
- W3087930831 hasRelatedWork W2096589181 @default.
- W3087930831 hasRelatedWork W2146521374 @default.
- W3087930831 hasRelatedWork W2149191753 @default.
- W3087930831 hasRelatedWork W2344842521 @default.
- W3087930831 hasRelatedWork W2404582479 @default.
- W3087930831 hasRelatedWork W2409786011 @default.
- W3087930831 hasRelatedWork W2414229366 @default.
- W3087930831 hasRelatedWork W2417870057 @default.
- W3087930831 hasVolume "12" @default.
- W3087930831 isParatext "false" @default.
- W3087930831 isRetracted "false" @default.
- W3087930831 magId "3087930831" @default.
- W3087930831 workType "article" @default.