FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3087993405> ?p ?o ?g. }

• W3087993405 endingPage "3348" @default.
• W3087993405 startingPage "3337" @default.
• W3087993405 abstract "Urolithins are gut microbiota-derived polyphenol metabolites, produced following the consumption of pomegranate, berries, and nuts. Recent studies have shown the potentials of these metabolites on reducing triglycerides accumulation in cultured hepatocytes and adipocytes. In this study, we investigated the ability of both urolithin A (Uro-A) and urolithin B (Uro-B) to attenuate obesity and associated symptoms in a high-fat diet-induced obesity model in rats.Twenty-four male Wistar rats were randomly assigned to four groups. Group 1 was fed on a normal diet while groups 2, 3, and 4 were fed on a high-fat diet for 10 weeks. After this, groups 3 and 4 were treated with 2.5mg/kg body weight of Uro-A and Uro-B intraperitoneally, respectively. Body weight, serum lipid profile, hepatic antioxidant activity, hepatic lipid accumulation, fecal lipid content, and the expressions of genes involved in lipogenesis and hepatic ER stress were quantified.Indeed, a high-fat diet resulted in increased body weight, visceral adipose tissue mass, and oxidative stress in rats. However, treatment with both Uro-A and Uro-B decreased body weight and visceral adipose tissue mass. These metabolites restored hepatic antioxidant capacity and decreased lipid accumulation in addition to an increase in fecal fat excretion. Moreover, both Uro-A and Uro-B treatment downregulated the expression of LXRα and SREBP1c; involved in de novo lipogenesis while upregulating PPARα expression for increased fatty acid oxidation. Furthermore, Uro-A and Uro-B decreased the expression of PERK and IRE1α; which are involved in hepatic ER stress. Taken together, our results showed the potentials of Uro-A and Uro-B in mitigating obesity symptoms and they could thus provide promising roles in the future as functional anti-obesity candidates." @default.
• W3087993405 created "2020-10-01" @default.
• W3087993405 creator A5021147919 @default.
• W3087993405 creator A5046592525 @default.
• W3087993405 creator A5068392011 @default.
• W3087993405 creator A5072503613 @default.
• W3087993405 creator A5076959773 @default.
• W3087993405 creator A5086232425 @default.
• W3087993405 date "2020-09-01" @default.
• W3087993405 modified "2023-10-17" @default.
• W3087993405 title "<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>" @default.
• W3087993405 cites W1534724641 @default.
• W3087993405 cites W191793640 @default.
• W3087993405 cites W1924047294 @default.
• W3087993405 cites W1968232450 @default.
• W3087993405 cites W1968375269 @default.
• W3087993405 cites W1983310681 @default.
• W3087993405 cites W1986371908 @default.
• W3087993405 cites W1994014704 @default.
• W3087993405 cites W2005074596 @default.
• W3087993405 cites W2007078899 @default.
• W3087993405 cites W2015190417 @default.
• W3087993405 cites W2023536393 @default.
• W3087993405 cites W2037007921 @default.
• W3087993405 cites W2037229791 @default.
• W3087993405 cites W2047475718 @default.
• W3087993405 cites W2055207613 @default.
• W3087993405 cites W2057114766 @default.
• W3087993405 cites W2063997051 @default.
• W3087993405 cites W2065612971 @default.
• W3087993405 cites W2082861825 @default.
• W3087993405 cites W2086482588 @default.
• W3087993405 cites W2088929386 @default.
• W3087993405 cites W2089453670 @default.
• W3087993405 cites W2095968062 @default.
• W3087993405 cites W2097046090 @default.
• W3087993405 cites W2107277218 @default.
• W3087993405 cites W2121195629 @default.
• W3087993405 cites W2124821727 @default.
• W3087993405 cites W2128635872 @default.
• W3087993405 cites W2130994151 @default.
• W3087993405 cites W2132066544 @default.
• W3087993405 cites W2143470388 @default.
• W3087993405 cites W2168526937 @default.
• W3087993405 cites W2173594576 @default.
• W3087993405 cites W2253854760 @default.
• W3087993405 cites W2281200461 @default.
• W3087993405 cites W2346306153 @default.
• W3087993405 cites W2530291414 @default.
• W3087993405 cites W2545495549 @default.
• W3087993405 cites W2729098679 @default.
• W3087993405 cites W2762689525 @default.
• W3087993405 cites W2769219455 @default.
• W3087993405 cites W2783268361 @default.
• W3087993405 cites W2808953112 @default.
• W3087993405 cites W2811501094 @default.
• W3087993405 cites W2912568548 @default.
• W3087993405 cites W2996873961 @default.
• W3087993405 cites W4293247451 @default.
• W3087993405 cites W1964184380 @default.
• W3087993405 doi "https://doi.org/10.2147/dmso.s268146" @default.
• W3087993405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7524201" @default.
• W3087993405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33061495" @default.
• W3087993405 hasPublicationYear "2020" @default.
• W3087993405 type Work @default.
• W3087993405 sameAs 3087993405 @default.
• W3087993405 citedByCount "27" @default.
• W3087993405 countsByYear W30879934052021 @default.
• W3087993405 countsByYear W30879934052022 @default.
• W3087993405 countsByYear W30879934052023 @default.
• W3087993405 crossrefType "journal-article" @default.
• W3087993405 hasAuthorship W3087993405A5021147919 @default.
• W3087993405 hasAuthorship W3087993405A5046592525 @default.
• W3087993405 hasAuthorship W3087993405A5068392011 @default.
• W3087993405 hasAuthorship W3087993405A5072503613 @default.
• W3087993405 hasAuthorship W3087993405A5076959773 @default.
• W3087993405 hasAuthorship W3087993405A5086232425 @default.
• W3087993405 hasBestOaLocation W30879934051 @default.
• W3087993405 hasConcept C126322002 @default.
• W3087993405 hasConcept C134018914 @default.
• W3087993405 hasConcept C141359234 @default.
• W3087993405 hasConcept C171089720 @default.
• W3087993405 hasConcept C185592680 @default.
• W3087993405 hasConcept C2776151105 @default.
• W3087993405 hasConcept C2778004101 @default.
• W3087993405 hasConcept C511355011 @default.
• W3087993405 hasConcept C55493867 @default.
• W3087993405 hasConcept C71924100 @default.
• W3087993405 hasConcept C86803240 @default.
• W3087993405 hasConceptScore W3087993405C126322002 @default.
• W3087993405 hasConceptScore W3087993405C134018914 @default.
• W3087993405 hasConceptScore W3087993405C141359234 @default.
• W3087993405 hasConceptScore W3087993405C171089720 @default.
• W3087993405 hasConceptScore W3087993405C185592680 @default.
• W3087993405 hasConceptScore W3087993405C2776151105 @default.
• W3087993405 hasConceptScore W3087993405C2778004101 @default.
• W3087993405 hasConceptScore W3087993405C511355011 @default.
• W3087993405 hasConceptScore W3087993405C55493867 @default.

• next