Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088049006> ?p ?o ?g. }
- W3088049006 abstract "The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown of mondoa impaired the early morphogenetic movement of epiboly in zebrafish embryos and caused microtubule defects. Expression of genes in the terpenoid backbone and sterol biosynthesis pathways upstream of pregnenolone synthesis was coordinately downregulated in these embryos, including the most downregulated gene nsdhl . Loss of Nsdhl function likewise impaired epiboly, similar to MondoA loss of function. Both epiboly and microtubule defects were partially restored by pregnenolone treatment. Maternal-zygotic mutants of mondoa showed perturbed epiboly with low penetrance and compensatory changes in the expression of terpenoid/sterol/steroid metabolism genes. Collectively, our results show a novel role for MondoA in the regulation of early vertebrate development, connecting glucose, cholesterol and steroid hormone metabolism with early embryonic cell movements." @default.
- W3088049006 created "2020-10-01" @default.
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- W3088049006 date "2020-09-24" @default.
- W3088049006 modified "2023-10-05" @default.
- W3088049006 title "MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly" @default.
- W3088049006 cites W1538904514 @default.
- W3088049006 cites W1556193709 @default.
- W3088049006 cites W1748636648 @default.
- W3088049006 cites W183376958 @default.
- W3088049006 cites W1875175558 @default.
- W3088049006 cites W1964330120 @default.
- W3088049006 cites W1968695334 @default.
- W3088049006 cites W1968883761 @default.
- W3088049006 cites W1969709039 @default.
- W3088049006 cites W1970751828 @default.
- W3088049006 cites W1971831631 @default.
- W3088049006 cites W1976091561 @default.
- W3088049006 cites W1978122588 @default.
- W3088049006 cites W1978806262 @default.
- W3088049006 cites W1979921085 @default.
- W3088049006 cites W1980719927 @default.
- W3088049006 cites W1981853910 @default.
- W3088049006 cites W1985843365 @default.
- W3088049006 cites W1986646687 @default.
- W3088049006 cites W1995439017 @default.
- W3088049006 cites W1997609660 @default.
- W3088049006 cites W2006664822 @default.
- W3088049006 cites W2008594083 @default.
- W3088049006 cites W2009781469 @default.
- W3088049006 cites W2010780698 @default.
- W3088049006 cites W2011044632 @default.
- W3088049006 cites W2012369470 @default.
- W3088049006 cites W2016029650 @default.
- W3088049006 cites W2020541351 @default.
- W3088049006 cites W2020994612 @default.
- W3088049006 cites W2023522077 @default.
- W3088049006 cites W2026536799 @default.
- W3088049006 cites W2027273404 @default.
- W3088049006 cites W2028659881 @default.
- W3088049006 cites W2031312855 @default.
- W3088049006 cites W2034583982 @default.
- W3088049006 cites W2039928578 @default.
- W3088049006 cites W2043357295 @default.
- W3088049006 cites W2048072153 @default.
- W3088049006 cites W2049784603 @default.
- W3088049006 cites W2054560553 @default.
- W3088049006 cites W2056304473 @default.
- W3088049006 cites W2059320568 @default.
- W3088049006 cites W2061927929 @default.
- W3088049006 cites W2062033938 @default.
- W3088049006 cites W2063482608 @default.
- W3088049006 cites W2066728242 @default.
- W3088049006 cites W2072812592 @default.
- W3088049006 cites W2073057651 @default.
- W3088049006 cites W2082839015 @default.
- W3088049006 cites W2083042943 @default.
- W3088049006 cites W2087847752 @default.
- W3088049006 cites W2088735475 @default.
- W3088049006 cites W2089491135 @default.
- W3088049006 cites W2093410495 @default.
- W3088049006 cites W2095238531 @default.
- W3088049006 cites W2096251733 @default.
- W3088049006 cites W2104065792 @default.
- W3088049006 cites W2107277218 @default.
- W3088049006 cites W2107852539 @default.
- W3088049006 cites W2108234281 @default.
- W3088049006 cites W2110065044 @default.
- W3088049006 cites W2111065008 @default.
- W3088049006 cites W2112220625 @default.
- W3088049006 cites W2116428404 @default.
- W3088049006 cites W2122598723 @default.
- W3088049006 cites W2124821411 @default.
- W3088049006 cites W2125349610 @default.
- W3088049006 cites W2126388402 @default.
- W3088049006 cites W2129252835 @default.
- W3088049006 cites W2131130409 @default.
- W3088049006 cites W2132581785 @default.
- W3088049006 cites W2140543218 @default.
- W3088049006 cites W2145055902 @default.
- W3088049006 cites W2146512944 @default.
- W3088049006 cites W2147046255 @default.
- W3088049006 cites W2148528862 @default.
- W3088049006 cites W2151370485 @default.
- W3088049006 cites W2153477752 @default.