FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088069314> ?p ?o ?g. }

• W3088069314 endingPage "589" @default.
• W3088069314 startingPage "583" @default.
• W3088069314 abstract "Drug–drug interactions (DDIs) cause significant morbidity and mortality, especially in patients with HIV with opportunistic infections such as tuberculosis. However, the literature on quantitative signal detection analyses for DDIs within the national spontaneous reporting systems (SRSs) of countries with high HIV/tuberculosis burdens is lacking. Our objective was to explore the utility of using post-marketing SRSs in quantitative signal detection analyses of DDIs. A case/non-case analysis using the Zimbabwean adverse drug reaction (ADR) database obtained from VigiBase® was utilized for quantitative signal detection using 2 × 2 contingency table calculations. Cases were defined as individual case safety reports (ICSRs) with the ADR of interest, and non-cases included the rest of the ICSRs. The exposure of interest was the use of a drug of interest. Signals of disproportionate reporting (SDRs) were observed for hepatotoxicity for the combined use of highly active antiretroviral therapy (HAART) and antitubercular treatments (ATT) [ADR reporting odds ratio (ROR) 43.78; 95% CI 5.24–366.08], HAART and isoniazid (ROR 44.84; 95% CI 5.36–374.99), and isoniazid and nevirapine-based HAART (ROR 35.60; 95% CI 9.39–134.89). SDRs were also observed for the combined use of nevirapine-based HAART and co-trimoxazole for Stevens–Johnson syndrome (ROR 28.91; 95% CI 14.00–59.70), severe cutaneous ADRs (ROR 16.10; 95% CI 9.40–27.57), and rash (OR 2.18; 95% CI 1.69–2.81). It is feasible to conduct signal detection analyses for DDIs within relatively small SRS databases. However, the observed potential SDR for the respective DDI should be investigated further as the method is only a hypothesis-generation analysis." @default.
• W3088069314 created "2020-10-01" @default.
• W3088069314 creator A5000417043 @default.
• W3088069314 creator A5012719809 @default.
• W3088069314 creator A5091624853 @default.
• W3088069314 date "2020-09-22" @default.
• W3088069314 modified "2023-10-10" @default.
• W3088069314 title "Exploring the utility of a spontaneous adverse drug reaction reporting system in identifying drug–drug interactions between antiretrovirals, antitubercular drugs, and cotrimoxazole: a case/non-case analysis" @default.
• W3088069314 cites W1514755903 @default.
• W3088069314 cites W1562265147 @default.
• W3088069314 cites W1762915406 @default.
• W3088069314 cites W1856490756 @default.
• W3088069314 cites W192934413 @default.
• W3088069314 cites W2004281677 @default.
• W3088069314 cites W2012026695 @default.
• W3088069314 cites W2021920492 @default.
• W3088069314 cites W2024985940 @default.
• W3088069314 cites W2037649732 @default.
• W3088069314 cites W2038397660 @default.
• W3088069314 cites W2052252723 @default.
• W3088069314 cites W2057881684 @default.
• W3088069314 cites W2064716383 @default.
• W3088069314 cites W2095749895 @default.
• W3088069314 cites W2098730643 @default.
• W3088069314 cites W2119493899 @default.
• W3088069314 cites W2128552449 @default.
• W3088069314 cites W2131647146 @default.
• W3088069314 cites W2140742736 @default.
• W3088069314 cites W2159298060 @default.
• W3088069314 cites W2335638314 @default.
• W3088069314 cites W2463669415 @default.
• W3088069314 cites W2477727413 @default.
• W3088069314 cites W2601701713 @default.
• W3088069314 cites W2605856369 @default.
• W3088069314 cites W2611564992 @default.
• W3088069314 cites W2759292668 @default.
• W3088069314 cites W2912814195 @default.
• W3088069314 cites W2988170839 @default.
• W3088069314 cites W3004054176 @default.
• W3088069314 cites W3005815093 @default.
• W3088069314 cites W3022784957 @default.
• W3088069314 cites W3086441718 @default.
• W3088069314 cites W763515031 @default.
• W3088069314 doi "https://doi.org/10.1007/s40267-020-00779-x" @default.
• W3088069314 hasPublicationYear "2020" @default.
• W3088069314 type Work @default.
• W3088069314 sameAs 3088069314 @default.
• W3088069314 citedByCount "0" @default.
• W3088069314 crossrefType "journal-article" @default.
• W3088069314 hasAuthorship W3088069314A5000417043 @default.
• W3088069314 hasAuthorship W3088069314A5012719809 @default.
• W3088069314 hasAuthorship W3088069314A5091624853 @default.
• W3088069314 hasBestOaLocation W30880693142 @default.
• W3088069314 hasConcept C126322002 @default.
• W3088069314 hasConcept C142462285 @default.
• W3088069314 hasConcept C142724271 @default.
• W3088069314 hasConcept C177713679 @default.
• W3088069314 hasConcept C203014093 @default.
• W3088069314 hasConcept C2778570526 @default.
• W3088069314 hasConcept C2779130552 @default.
• W3088069314 hasConcept C2780035454 @default.
• W3088069314 hasConcept C2780542314 @default.
• W3088069314 hasConcept C2781069245 @default.
• W3088069314 hasConcept C2993143319 @default.
• W3088069314 hasConcept C3013748606 @default.
• W3088069314 hasConcept C57658597 @default.
• W3088069314 hasConcept C71924100 @default.
• W3088069314 hasConcept C98274493 @default.
• W3088069314 hasConceptScore W3088069314C126322002 @default.
• W3088069314 hasConceptScore W3088069314C142462285 @default.
• W3088069314 hasConceptScore W3088069314C142724271 @default.
• W3088069314 hasConceptScore W3088069314C177713679 @default.
• W3088069314 hasConceptScore W3088069314C203014093 @default.
• W3088069314 hasConceptScore W3088069314C2778570526 @default.
• W3088069314 hasConceptScore W3088069314C2779130552 @default.
• W3088069314 hasConceptScore W3088069314C2780035454 @default.
• W3088069314 hasConceptScore W3088069314C2780542314 @default.
• W3088069314 hasConceptScore W3088069314C2781069245 @default.
• W3088069314 hasConceptScore W3088069314C2993143319 @default.
• W3088069314 hasConceptScore W3088069314C3013748606 @default.
• W3088069314 hasConceptScore W3088069314C57658597 @default.
• W3088069314 hasConceptScore W3088069314C71924100 @default.
• W3088069314 hasConceptScore W3088069314C98274493 @default.
• W3088069314 hasIssue "12" @default.
• W3088069314 hasLocation W30880693141 @default.
• W3088069314 hasLocation W30880693142 @default.
• W3088069314 hasOpenAccess W3088069314 @default.
• W3088069314 hasPrimaryLocation W30880693141 @default.
• W3088069314 hasRelatedWork W1970299515 @default.
• W3088069314 hasRelatedWork W1990964652 @default.
• W3088069314 hasRelatedWork W2009737011 @default.
• W3088069314 hasRelatedWork W2219081204 @default.
• W3088069314 hasRelatedWork W2759292668 @default.
• W3088069314 hasRelatedWork W2898765557 @default.
• W3088069314 hasRelatedWork W3091971250 @default.
• W3088069314 hasRelatedWork W3137220598 @default.
• W3088069314 hasRelatedWork W56637561 @default.
• W3088069314 hasRelatedWork W96370330 @default.

• next