FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088115737> ?p ?o ?g. }

• W3088115737 abstract "Background: Osteoarthritis is the most common degenerative joint disease. This study has focus on osteoarthritis (OA) of knees which primarily affects the elderly causing functional impairment and disability. There are no interventions that can completely reverse the disease progression by restoring degraded cartilage; however, symptoms can usually be effectively managed with lifestyle changes, physical and other therapies, medications, and surgery. Further, the existing studies have evaluated benefit of single herb or its essential oil towards treatment of OA pain or a symptom.  Objective: The proposed polyherbal oil (referred as test product) is a unique synergistic oil blend prepared using novel concept of Ayurveda Plant Nanocellopathy, as elaborated in the Sarangdhar Samhita, that blends therapeutic plant extracts/ oils to derive maximum benefit from the herb extracts/ oils having soothing, analgesics and anti-inflammatory properties. The objective of this study is to validate the efficacy of the topical use of the test product in treatment and control, and stopping or delaying progression of knee OA in comparison with the placebo.  Method: A randomized, double blind, parallel group, placebo controlled comparative study with 200 adult participants having OA of the knee was conducted. The participants who fulfilled the inclusion criteria were allocated between two study arms (test and placebo) in the ratio of 1:1 using randomization. The efficacy of the test product was measured as a decrease or negative change in VAS as well as WOMAC Index scores. Progression of OA, or regression of it was assessed radiographically by comparing the post and pre-treatment X-rays measured on K & L grade and joint space narrowing results. The safety of the test product was assessed in terms of adverse events, if any.  Findings: The decrease in the WOMAC Index score and VAS-POM score in test group was observed on a continuous basis, that is, from baseline to day 30 and then decreasing in subsequent follow-up visits on day 60 and day 90, suggesting that continuous use of the test product was beneficial to provide relief from symptoms. Significantly fewer participants with K & L grade >1 using test product showed progression in OA as compared to the placebo group. The test product did not result in any adverse events indicating safety of the oil use.  Conclusion: Topical application of test product is found effective in relieving the symptoms of knee OA and stopping progression of knee OA without any reported side-effects." @default.
• W3088115737 created "2020-10-01" @default.
• W3088115737 creator A5040009868 @default.
• W3088115737 date "2020-01-01" @default.
• W3088115737 modified "2023-09-23" @default.
• W3088115737 title "Efficacy of Plant-Extract Based Oil-Blends for Osteoarthritis of Knee Randomized, Double Blind, and Placebo Controlled Study" @default.
• W3088115737 hasPublicationYear "2020" @default.
• W3088115737 type Work @default.
• W3088115737 sameAs 3088115737 @default.
• W3088115737 citedByCount "0" @default.
• W3088115737 crossrefType "journal-article" @default.
• W3088115737 hasAuthorship W3088115737A5040009868 @default.
• W3088115737 hasConcept C141071460 @default.
• W3088115737 hasConcept C142724271 @default.
• W3088115737 hasConcept C168563851 @default.
• W3088115737 hasConcept C1862650 @default.
• W3088115737 hasConcept C204243189 @default.
• W3088115737 hasConcept C204787440 @default.
• W3088115737 hasConcept C27081682 @default.
• W3088115737 hasConcept C2776164576 @default.
• W3088115737 hasConcept C2779286237 @default.
• W3088115737 hasConcept C71924100 @default.
• W3088115737 hasConceptScore W3088115737C141071460 @default.
• W3088115737 hasConceptScore W3088115737C142724271 @default.
• W3088115737 hasConceptScore W3088115737C168563851 @default.
• W3088115737 hasConceptScore W3088115737C1862650 @default.
• W3088115737 hasConceptScore W3088115737C204243189 @default.
• W3088115737 hasConceptScore W3088115737C204787440 @default.
• W3088115737 hasConceptScore W3088115737C27081682 @default.
• W3088115737 hasConceptScore W3088115737C2776164576 @default.
• W3088115737 hasConceptScore W3088115737C2779286237 @default.
• W3088115737 hasConceptScore W3088115737C71924100 @default.
• W3088115737 hasIssue "4" @default.
• W3088115737 hasLocation W30881157371 @default.
• W3088115737 hasOpenAccess W3088115737 @default.
• W3088115737 hasPrimaryLocation W30881157371 @default.
• W3088115737 hasRelatedWork W1847692633 @default.
• W3088115737 hasRelatedWork W2021948566 @default.
• W3088115737 hasRelatedWork W2023116883 @default.
• W3088115737 hasRelatedWork W2053889264 @default.
• W3088115737 hasRelatedWork W2064044450 @default.
• W3088115737 hasRelatedWork W2181806056 @default.
• W3088115737 hasRelatedWork W2223056510 @default.
• W3088115737 hasRelatedWork W2306762854 @default.
• W3088115737 hasRelatedWork W2323144842 @default.
• W3088115737 hasRelatedWork W2333999922 @default.
• W3088115737 hasRelatedWork W2440580837 @default.
• W3088115737 hasRelatedWork W2481619775 @default.
• W3088115737 hasRelatedWork W2494003413 @default.
• W3088115737 hasRelatedWork W2791311332 @default.
• W3088115737 hasRelatedWork W2890030095 @default.
• W3088115737 hasRelatedWork W2898230549 @default.
• W3088115737 hasRelatedWork W2904670926 @default.
• W3088115737 hasRelatedWork W2994542126 @default.
• W3088115737 hasRelatedWork W3033222635 @default.
• W3088115737 hasRelatedWork W3041555230 @default.
• W3088115737 hasVolume "5" @default.
• W3088115737 isParatext "false" @default.
• W3088115737 isRetracted "false" @default.
• W3088115737 magId "3088115737" @default.
• W3088115737 workType "article" @default.