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• W3088144426 abstract "Background . The pathogenesis of thoracic aortopathy is complex, and much evidence suggests the influence of genetic factors. Some genes with polymorphisms are widely considered critical factors in the initiation and development of aortic aneurysm. The aim of our study was to analyze the association of genetic polymorphisms of MMP1 rs1799750 (c.-1607G>GG), MMP9 rs3918242 (c.-1562C>T), COL1A1 rs1800012 (c.1245G>T), and COL1A2 rs42524 (c.1645G>C) with predisposition to thoracic aortopathy in Polish patients and with clinical characteristics of these patients. Methods . The study was carried out with 96 patients with thoracic aortopathy (47 patients with ascending aortic aneurysm and 49 patients with thoracic aortic dissection) and 61 control subjects without thoracic aortopathy. The MMP1 , MMP9 , COL1A1 , and COL1A2 polymorphisms were determined by PCR-RFLP. Results . No significant differences in the frequency distributions of MMP1 , MMP9 , COL1A1 , and COL1A2 genotypes or alleles were found (1) between the control group and patients with ascending aortic aneurysm (AsAA), (2) between the control group and patients with thoracic aortic dissection (TAD), or (3) between AsAA and TAD patients. Multivariate logistic regression analysis revealed that MMP1 and MMP9 polymorphisms were associated with the degree of aortic valve regurgitation. Conclusion . The results of our study did not support associations between MMP1 , MMP9 , COL1A1 , and COL1A2 genetic variants with the risk of thoracic artery disease in Polish patients. However, rs1799750 MMP1 and rs3918242 MMP9 seem to be associated with the degree of aortic regurgitation." @default.
• W3088144426 created "2020-10-01" @default.
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• W3088144426 date "2020-09-24" @default.
• W3088144426 modified "2023-10-15" @default.
• W3088144426 title "Genetic Polymorphisms of<i>MMP1</i>,<i>MMP9</i>,<i>COL1A1</i>, and<i>COL1A2</i>in Polish Patients with Thoracic Aortopathy" @default.
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• W3088144426 doi "https://doi.org/10.1155/2020/9567239" @default.
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