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- W3088157024 abstract "Persistent infection of the bacterivore nematode C. elegans with bacteria such as P. aeruginosa and S. enterica makes the worm diapause or hibernate. By doing this, the worm closes its mouth, avoiding infection. This response takes two generations to be implemented. In this work, we looked for genes expressed upon infection that could mediate the worm diapause triggered by pathogens. We identify mir-243-3p as the only transcript commonly upregulated when animals feed on P. aeruginosa and S. enterica for two consecutive generations. Moreover, we demonstrate that mir-243-3p is required for pathogen-induced dauer formation, a new function that has not been previously described for this microRNA (miRNA). We also find that the transcriptional activators DAF-16, PQM-1, and CRH-2 are necessary for the expression of mir-243 under pathogenesis. Here we establish a relationship between a small RNA and a developmental change that ensures the survival of a percentage of the progeny." @default.
- W3088157024 created "2020-10-01" @default.
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- W3088157024 date "2020-10-27" @default.
- W3088157024 modified "2023-10-16" @default.
- W3088157024 title "Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by <i>mir-243</i>" @default.
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- W3088157024 doi "https://doi.org/10.1128/mbio.01950-20" @default.
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