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- W3088191720 abstract "Modular β-borylacrylates have been validated as programmable, ambiphilic C3 -synthons in the cascade annulation of 2-halo-phenol derivatives to generate structurally and electronically diverse coumarins. Key to this [3+3] disconnection is the BPin unit which serves a dual purpose as both a traceless linker for C(sp2 )-C(sp2 ) coupling, and as a chromophore extension to enable inversion of the alkene geometry via selective energy transfer catalysis. Mild isomerisation is a pre-condition to access 3-substituted coumarins and provides a handle for divergence. The method is showcased in the synthesis of representative natural products that contain this venerable chemotype. Facile entry into π-expanded estrone derivatives modified at the A-ring is disclosed to demonstrate the potential of the method in bioassay development or in drug repurposing." @default.
- W3088191720 created "2020-10-01" @default.
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- W3088191720 date "2020-11-09" @default.
- W3088191720 modified "2023-10-12" @default.
- W3088191720 title "Coumarins by Direct Annulation: β‐Borylacrylates as Ambiphilic C <sub>3</sub> ‐Synthons" @default.
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- W3088191720 doi "https://doi.org/10.1002/anie.202012099" @default.
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