FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088206557> ?p ?o ?g. }

• W3088206557 abstract "Objective: This study aimed to look into the relationship between intensity-modulated-radiotherapy (IMRT)- or volumetric-modulated-arc-therapy (VMAT)-based dose-volume parameters and 5-year outcome for a consecutive series of non-metastatic nasopharyngeal cancer (NPC) patients (pts) treated in a single institution in a non-endemic area in order to identify potential prognostic factors. Materials and methods: A retrospective analysis of consecutive non-metastatic NPC pts treated curatively with IMRT or VMAT and chemotherapy (CHT) between 2004 and 2014 was conducted. One patient was in stage I (0.7%), and 24 pts (17.5%) were in stage II, 38 pts (27.7%) in stage III, 29 pts (21.2%) in stage IVA, and 45 pts (32.8%) in stage IVB. Five pts (3.6%) received radiotherapy (RT) alone. Of the remaining 132 pts (96.4%), 30 pts (21.9%) received CHT concomitant to RT, and 102 pts (74.4%) were treated with induction CHT followed by RT-CHT. IMRT was given with standard fractionation at a total dose of 70 Gy. Clinical outcomes investigated in the study were local control (LC), disease-free survival (DFS), and overall survival (OS). Kaplan-Meier (KM) analysis was performed for the outcomes considering dose and coverage parameters, staging, and RT technique. Results: Overall, 137 pts were eligible for this retrospective analysis. With a median follow-up of 70 months (range 12-143), actuarial rates at 5 years were LC 90.4, DFS 77.2, and OS 82.8%. For this preliminary study, T stage was dichotomized as T1, T2, T3 vs. T4. At 5 years, the group T1-T2-T3 reported an LC of 93%, a DFS of 79%, and an OS of 88%, whereas T4 pts reported LC, DFS, and OS, respectively, of 56, 50, and 78%. Pts with V95% > 95.5% had better LC (p = 0.006). Pts with D99% > 63.8 Gy had better LC (p = 0.034) and OS (p = 0.005). The threshold value of 43.2 cm3 of GTVT was prognostic for LC (p = 0.016). To predict the risk of local recurrence at 5 years, we constructed a nomogram which combined GTVT with D99% relative to HRPTV. Conclusions: We demonstrated the prognostic value of some dose-volume parameters, although in a retrospective series, this is potentially useful to improve planning procedure. In addition, for the first time in a non-endemic area, a threshold value of GTVT, prognostic for LC, has been confirmed." @default.
• W3088206557 created "2020-10-01" @default.
• W3088206557 creator A5007046109 @default.
• W3088206557 creator A5007168895 @default.
• W3088206557 creator A5014239599 @default.
• W3088206557 creator A5017363293 @default.
• W3088206557 creator A5018624121 @default.
• W3088206557 creator A5026618047 @default.
• W3088206557 creator A5026955665 @default.
• W3088206557 creator A5029235673 @default.
• W3088206557 creator A5044893326 @default.
• W3088206557 creator A5047193688 @default.
• W3088206557 creator A5052156214 @default.
• W3088206557 creator A5067540429 @default.
• W3088206557 creator A5069750407 @default.
• W3088206557 creator A5070422496 @default.
• W3088206557 creator A5073202790 @default.
• W3088206557 creator A5074487260 @default.
• W3088206557 creator A5075219078 @default.
• W3088206557 creator A5081945327 @default.
• W3088206557 creator A5083335271 @default.
• W3088206557 date "2020-09-24" @default.
• W3088206557 modified "2023-10-16" @default.
• W3088206557 title "Role of IMRT/VMAT-Based Dose and Volume Parameters in Predicting 5-Year Local Control and Survival in Nasopharyngeal Cancer Patients" @default.
• W3088206557 cites W1939558678 @default.
• W3088206557 cites W1969762178 @default.
• W3088206557 cites W1976058023 @default.
• W3088206557 cites W2009262068 @default.
• W3088206557 cites W2017276054 @default.
• W3088206557 cites W2018591204 @default.
• W3088206557 cites W2024847643 @default.
• W3088206557 cites W2045352770 @default.
• W3088206557 cites W2056143938 @default.
• W3088206557 cites W2059775855 @default.
• W3088206557 cites W2091603229 @default.
• W3088206557 cites W2093953673 @default.
• W3088206557 cites W2096388800 @default.
• W3088206557 cites W2102310008 @default.
• W3088206557 cites W2142060823 @default.
• W3088206557 cites W2146701819 @default.
• W3088206557 cites W2154235424 @default.
• W3088206557 cites W2166417665 @default.
• W3088206557 cites W2171982488 @default.
• W3088206557 cites W2551619289 @default.
• W3088206557 cites W2613804359 @default.
• W3088206557 cites W2734216713 @default.
• W3088206557 cites W2747802520 @default.
• W3088206557 cites W2752253671 @default.
• W3088206557 cites W2768968764 @default.
• W3088206557 cites W2771702261 @default.
• W3088206557 cites W2930745331 @default.
• W3088206557 cites W2954237769 @default.
• W3088206557 cites W2963330744 @default.
• W3088206557 cites W2977314049 @default.
• W3088206557 cites W4250377599 @default.
• W3088206557 doi "https://doi.org/10.3389/fonc.2020.518110" @default.
• W3088206557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7541899" @default.
• W3088206557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33072562" @default.
• W3088206557 hasPublicationYear "2020" @default.
• W3088206557 type Work @default.
• W3088206557 sameAs 3088206557 @default.
• W3088206557 citedByCount "8" @default.
• W3088206557 countsByYear W30882065572020 @default.
• W3088206557 countsByYear W30882065572021 @default.
• W3088206557 countsByYear W30882065572022 @default.
• W3088206557 countsByYear W30882065572023 @default.
• W3088206557 crossrefType "journal-article" @default.
• W3088206557 hasAuthorship W3088206557A5007046109 @default.
• W3088206557 hasAuthorship W3088206557A5007168895 @default.
• W3088206557 hasAuthorship W3088206557A5014239599 @default.
• W3088206557 hasAuthorship W3088206557A5017363293 @default.
• W3088206557 hasAuthorship W3088206557A5018624121 @default.
• W3088206557 hasAuthorship W3088206557A5026618047 @default.
• W3088206557 hasAuthorship W3088206557A5026955665 @default.
• W3088206557 hasAuthorship W3088206557A5029235673 @default.
• W3088206557 hasAuthorship W3088206557A5044893326 @default.
• W3088206557 hasAuthorship W3088206557A5047193688 @default.
• W3088206557 hasAuthorship W3088206557A5052156214 @default.
• W3088206557 hasAuthorship W3088206557A5067540429 @default.
• W3088206557 hasAuthorship W3088206557A5069750407 @default.
• W3088206557 hasAuthorship W3088206557A5070422496 @default.
• W3088206557 hasAuthorship W3088206557A5073202790 @default.
• W3088206557 hasAuthorship W3088206557A5074487260 @default.
• W3088206557 hasAuthorship W3088206557A5075219078 @default.
• W3088206557 hasAuthorship W3088206557A5081945327 @default.
• W3088206557 hasAuthorship W3088206557A5083335271 @default.
• W3088206557 hasBestOaLocation W30882065571 @default.
• W3088206557 hasConcept C121608353 @default.
• W3088206557 hasConcept C126322002 @default.
• W3088206557 hasConcept C143998085 @default.
• W3088206557 hasConcept C146357865 @default.
• W3088206557 hasConcept C151730666 @default.
• W3088206557 hasConcept C167135981 @default.
• W3088206557 hasConcept C2778997737 @default.
• W3088206557 hasConcept C2779384505 @default.
• W3088206557 hasConcept C2989005 @default.
• W3088206557 hasConcept C2992261824 @default.
• W3088206557 hasConcept C509974204 @default.
• W3088206557 hasConcept C71924100 @default.
• W3088206557 hasConcept C86803240 @default.

• next