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• W3088258981 abstract "To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an extensive PRS online repository for 35 common cancer traits integrating freely available genome-wide association studies (GWASs) summary statistics from three sources: published GWASs, the NHGRI-EBI GWAS Catalog, and UK Biobank-based GWASs. Our framework condenses these summary statistics into PRSs using various approaches such as linkage disequilibrium pruning/p value thresholding (fixed or data-adaptively optimized thresholds) and penalized, genome-wide effect size weighting. We evaluated the PRSs in two biobanks: the Michigan Genomics Initiative (MGI), a longitudinal biorepository effort at Michigan Medicine, and the population-based UK Biobank (UKB). For each PRS construct, we provide measures on predictive performance and discrimination. Besides PRS evaluation, the Cancer-PRSweb platform features construct downloads and phenome-wide PRS association study results (PRS-PheWAS) for predictive PRSs. We expect this integrated platform to accelerate PRS-related cancer research." @default.
• W3088258981 created "2020-10-01" @default.
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• W3088258981 date "2020-11-01" @default.
• W3088258981 modified "2023-10-16" @default.
• W3088258981 title "Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks" @default.
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• W3088258981 doi "https://doi.org/10.1016/j.ajhg.2020.08.025" @default.
• W3088258981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7675001" @default.
• W3088258981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32991828" @default.

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