FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088266417> ?p ?o ?g. }

• W3088266417 endingPage "2719" @default.
• W3088266417 startingPage "2719" @default.
• W3088266417 abstract "Cancer cells facilitate growth and metastasis by using multiple signals from the cancer-associated microenvironment. However, it remains poorly understood whether prostate cancer (PCa) cells may recruit and utilize bone marrow cells for their growth and survival. Furthermore, the regulatory mechanisms underlying interactions between PCa cells and bone marrow cells are obscure. In this study, we isolated bone marrow cells that mainly constituted populations that were positive for CD11b and Gr1 antigens from xenograft PC-3 tumor tissues from athymic nu/nu mice. We found that the tumor-infiltrated cells alone were unable to form tumor spheroids, even with increased amounts and time. By contrast, the tumor-infiltrated cells together with PCa cells formed large numbers of tumor spheroids compared with PCa cells alone. We further utilized xenograft athymic nu/nu mice bearing bone metastatic lesions. We demonstrated that PCa cells were unable to survive and give rise to colony-forming units (CFUs) in media that were used for hematopoietic cell colony-formation unit (CFU) assays. By contrast, PC-3M cells survived when bone marrow cells were present and gave rise to CFUs. Our results showed that PCa cells required bone marrow cells to support their growth and survival and establish bone metastasis in the host environment. We showed that PCa cells that were treated with either siRNA for PIP5K1α or its specific inhibitor, ISA-2011B, were unable to survive and produce tumor spheroids, together with bone marrow cells. Given that the elevated expression of PIP5K1α was specific for PCa cells and was associated with the induced expression of VEGF receptor 2 in PCa cells, our findings suggest that cancer cells may utilize PIP5K1α-mediated receptor signaling to recruit growth factors and ligands from the bone marrow-derived cells. Taken together, our study suggests a new mechanism that enables PCa cells to gain proliferative and invasive advantages within their associated host microenvironment. Therapeutic interventions using PIP5K1α inhibitors may not only inhibit tumor invasion and metastasis but also enhance the host immune system." @default.
• W3088266417 created "2020-10-01" @default.
• W3088266417 creator A5002392039 @default.
• W3088266417 creator A5004229530 @default.
• W3088266417 creator A5012690658 @default.
• W3088266417 creator A5019387858 @default.
• W3088266417 creator A5026119237 @default.
• W3088266417 creator A5034428756 @default.
• W3088266417 creator A5045831969 @default.
• W3088266417 creator A5048631571 @default.
• W3088266417 creator A5056987185 @default.
• W3088266417 creator A5060249631 @default.
• W3088266417 creator A5065506726 @default.
• W3088266417 creator A5074463161 @default.
• W3088266417 creator A5076791622 @default.
• W3088266417 creator A5081131555 @default.
• W3088266417 creator A5083526044 @default.
• W3088266417 date "2020-09-22" @default.
• W3088266417 modified "2023-10-16" @default.
• W3088266417 title "Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase" @default.
• W3088266417 cites W1585754595 @default.
• W3088266417 cites W1624649331 @default.
• W3088266417 cites W1874739342 @default.
• W3088266417 cites W1998846966 @default.
• W3088266417 cites W2004316987 @default.
• W3088266417 cites W2014454127 @default.
• W3088266417 cites W2023075736 @default.
• W3088266417 cites W2023389612 @default.
• W3088266417 cites W2037885504 @default.
• W3088266417 cites W2049794935 @default.
• W3088266417 cites W2053970131 @default.
• W3088266417 cites W2071111320 @default.
• W3088266417 cites W2090716487 @default.
• W3088266417 cites W2108929503 @default.
• W3088266417 cites W2112966602 @default.
• W3088266417 cites W2117692326 @default.
• W3088266417 cites W2122403898 @default.
• W3088266417 cites W2130870648 @default.
• W3088266417 cites W2155533522 @default.
• W3088266417 cites W2171098112 @default.
• W3088266417 cites W2282887018 @default.
• W3088266417 cites W2509171004 @default.
• W3088266417 cites W2530700542 @default.
• W3088266417 cites W2554713037 @default.
• W3088266417 cites W2606513998 @default.
• W3088266417 cites W2887957127 @default.
• W3088266417 cites W2899585608 @default.
• W3088266417 cites W2964623867 @default.
• W3088266417 doi "https://doi.org/10.3390/cancers12092719" @default.
• W3088266417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7564679" @default.
• W3088266417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32971916" @default.
• W3088266417 hasPublicationYear "2020" @default.
• W3088266417 type Work @default.
• W3088266417 sameAs 3088266417 @default.
• W3088266417 citedByCount "4" @default.
• W3088266417 countsByYear W30882664172022 @default.
• W3088266417 countsByYear W30882664172023 @default.
• W3088266417 crossrefType "journal-article" @default.
• W3088266417 hasAuthorship W3088266417A5002392039 @default.
• W3088266417 hasAuthorship W3088266417A5004229530 @default.
• W3088266417 hasAuthorship W3088266417A5012690658 @default.
• W3088266417 hasAuthorship W3088266417A5019387858 @default.
• W3088266417 hasAuthorship W3088266417A5026119237 @default.
• W3088266417 hasAuthorship W3088266417A5034428756 @default.
• W3088266417 hasAuthorship W3088266417A5045831969 @default.
• W3088266417 hasAuthorship W3088266417A5048631571 @default.
• W3088266417 hasAuthorship W3088266417A5056987185 @default.
• W3088266417 hasAuthorship W3088266417A5060249631 @default.
• W3088266417 hasAuthorship W3088266417A5065506726 @default.
• W3088266417 hasAuthorship W3088266417A5074463161 @default.
• W3088266417 hasAuthorship W3088266417A5076791622 @default.
• W3088266417 hasAuthorship W3088266417A5081131555 @default.
• W3088266417 hasAuthorship W3088266417A5083526044 @default.
• W3088266417 hasBestOaLocation W30882664171 @default.
• W3088266417 hasConcept C109159458 @default.
• W3088266417 hasConcept C121608353 @default.
• W3088266417 hasConcept C126322002 @default.
• W3088266417 hasConcept C142724271 @default.
• W3088266417 hasConcept C185592680 @default.
• W3088266417 hasConcept C203014093 @default.
• W3088266417 hasConcept C2777783956 @default.
• W3088266417 hasConcept C2779013556 @default.
• W3088266417 hasConcept C2780007613 @default.
• W3088266417 hasConcept C2780192828 @default.
• W3088266417 hasConcept C28328180 @default.
• W3088266417 hasConcept C502942594 @default.
• W3088266417 hasConcept C54355233 @default.
• W3088266417 hasConcept C71924100 @default.
• W3088266417 hasConcept C81885089 @default.
• W3088266417 hasConcept C86803240 @default.
• W3088266417 hasConcept C95444343 @default.
• W3088266417 hasConcept C96232424 @default.
• W3088266417 hasConceptScore W3088266417C109159458 @default.
• W3088266417 hasConceptScore W3088266417C121608353 @default.
• W3088266417 hasConceptScore W3088266417C126322002 @default.
• W3088266417 hasConceptScore W3088266417C142724271 @default.
• W3088266417 hasConceptScore W3088266417C185592680 @default.
• W3088266417 hasConceptScore W3088266417C203014093 @default.

• next