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• W3088349748 abstract "Challenges to the diagnosis and treatment of patients with psychiatric disorders have long been acknowledged in the field. In recent years, efforts have been made to identify genomic biomarkers for psychiatric disorders. A link between immune function and major depressive disorder (MDD) has been suggested for decades ( 1 Raison C.L. Capuron L. Miller A.H. Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends Immunol. 2006; 27: 24-31 Abstract Full Text Full Text PDF PubMed Scopus (2081) Google Scholar ), but the identification of differentially expressed genes (DEGs) that underlie immune function as biomarkers for MDD has been more recent. Hundreds of DEGs have been reported for transcriptome-wide association studies (TWASs) of MDD. However, the majority of DEGs reported among individual studies do not overlap, making prioritization of candidate biomarkers challenging. Thus, integrating findings from multiple studies is critical to establish reliable DEGs as biomarkers for MDD. Leveraging publicly available datasets, Wittenberg et al. ( 2 Wittenberg G.M. Greene J. Vértes P.E. Drevets W.C. Bullmore E.T. Major depressive disorder is associated with differential expression of innate immune and neutrophil-related gene networks in peripheral blood: A quantitative review of whole-genome transcriptional data from case-control studies. Biol Psychiatry. 2020; 88: 625-637 Google Scholar ) demonstrated that integration of gene expression data from multiple studies provides new insights on immune gene function and gene networks for MDD. The identified genes and networks could serve as biomarkers for MDD. SEE CORRESPONDING ARTICLE ON PAGE 625 SEE CORRESPONDING ARTICLE ON PAGE 625 Major Depressive Disorder Is Associated With Differential Expression of Innate Immune and Neutrophil-Related Gene Networks in Peripheral Blood: A Quantitative Review of Whole-Genome Transcriptional Data From Case-Control StudiesBiological PsychiatryVol. 88Issue 8PreviewWhole-genome transcription has been measured in peripheral blood samples as a candidate biomarker of inflammation associated with major depressive disorder. Full-Text PDF Open Access" @default.
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• W3088349748 title "Searching for Genomic Biomarkers for Major Depressive Disorder in Peripheral Immune Cells" @default.
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• W3088349748 doi "https://doi.org/10.1016/j.biopsych.2020.07.021" @default.
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