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• W3088360097 abstract "Abstract Background Cocaine is an addictive, sympathomimetic drug with potentially lethal effects. We have previously shown with cardiovascular magnetic resonance (CMR) the presence of cardiovascular involvement in a significant percentage of consecutive asymptomatic cocaine addicts. CMR with feature-tracking analysis (CMR-FT) allows for the quantification of myocardial deformation which may detect preclinical involvement. Therefore, we aimed to assess the effects of cocaine on the left ventricular myocardium in a group of asymptomatic cocaine users with CMR-FT. Methods In a cohort of asymptomatic cocaine addicts (CA) who had been submitted to CMR at 3 T, we used CMR-FT to measure strain, strain rate and dyssynchrony index in CA with mildly decreased left ventricular ejection fraction (CA-LVEF d ) and in CA with preserved ejection fraction (CA-LVEF p ). We also measured these parameters in 30 age-matched healthy subjects. Results There were no differences according to age. Significant differences were seen in global longitudinal, radial and circumferential strain, in global longitudinal and radial strain rate and in radial and circumferential dyssynchrony index among the groups, with the lowest values in CA-LVEF d and intermediate values in CA-LVEF p . Longitudinal, radial and circumferential strain values were significantly lower in CA-LVEF p with respect to controls. Conclusions CA-LVEF p show decreased systolic strain and strain rate values, with intermediate values between healthy controls and CA-LVEF d . Signs suggestive of dyssynchrony were also detected. In CA, CMR-FT based strain analysis can detect early subclinical myocardial involvement." @default.
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• W3088360097 date "2020-09-28" @default.
• W3088360097 modified "2023-10-01" @default.
• W3088360097 title "Detection of subclinical myocardial dysfunction in cocaine addicts with feature tracking cardiovascular magnetic resonance" @default.
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• W3088360097 doi "https://doi.org/10.1186/s12968-020-00663-7" @default.
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