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• W3088365792 abstract "Persistence of bovine tuberculosis (bTB) in certain cattle herds is a major concern in countries pursuing disease eradication worldwide. The chronic nature of the disease, the lack of performance of diagnostic tools, and the presence of wildlife reservoirs may lead infected herds to require longer periods to achieve the officially tuberculosis free (OTF) status. Here, we evaluated the impact of farm and breakdown characteristics on the probability of disease persistence in infected farms in Castilla y Leon, a bTB-endemic region of Spain, using survival and logistic regression models. Data from bTB breakdowns occurring in 3,550 bTB positive herds detected in 2010-2017 were analyzed. A multivariable Cox proportional hazards model was fitted using time to recover OTF status as the response variable, and a multivariable logistic regression model using the chronic status (yes/no) for herds experiencing particularly long breakdowns as the outcome variable was also used. Both analyses revealed that county-level bTB herd prevalence, herd size, number of incoming animals in the previous 3 years and number of skin test reactors in the disclosing test were associated with increased breakdown duration. Production type was not consistently associated with chronic infection, suggesting that once infected it is not a significant predictor of outbreak duration beyond the initial stages of the breakdown. Province-level location and number of animals bacteriology-positive also affected significantly the expected herd breakdown duration, but their effect became less significant over time. Risk factors identified in this study may help to identify herds more prone to suffer chronic bTB infection that may require additional control measures early on in a breakdown." @default.
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• W3088365792 date "2020-09-25" @default.
• W3088365792 modified "2023-10-17" @default.
• W3088365792 title "Evaluation of Risk Factors Associated With Herds With an Increased Duration of Bovine Tuberculosis Breakdowns in Castilla y Leon, Spain (2010–2017)" @default.
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• W3088365792 doi "https://doi.org/10.3389/fvets.2020.545328" @default.
• W3088365792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7546324" @default.
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