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• W3088393729 abstract "Abstract The gram-negative, aerobic, rod-shaped bacterium Aeromonas hydrophila , the causative agent of motile aeromonad septicaemia, has attracted increasing attention due to its high pathogenicity. Here, we constructed the complete genome sequence of a virulent strain, A. hydrophila HX-3 isolated from Pseudosciaena crocea and performed comparative genomics to investigate its virulence factors and quorum sensing features in comparison with those of other Aeromonas isolates. HX-3 has a circular chromosome of 4,941,513 bp with a 61.0% G + C content encoding 4483 genes, including 4318 protein-coding genes, and 31 rRNA, 127 tRNA and 7 ncRNA operons. Seventy interspersed repeat and 153 tandem repeat sequences, 7 transposons, 8 clustered regularly interspaced short palindromic repeats, and 39 genomic islands were predicted in the A. hydrophila HX-3 genome. Phylogeny and pan-genome were also analyzed herein to confirm the evolutionary relationships on the basis of comparisons with other fully sequenced Aeromonas genomes. In addition, the assembled HX-3 genome was successfully annotated against the Cluster of Orthologous Groups of proteins database (76.03%), Gene Ontology database (18.13%), and Kyoto Encyclopedia of Genes and Genome pathway database (59.68%). Two-component regulatory systems in the HX-3 genome and virulence factors profiles through comparative analysis were predicted, providing insights into pathogenicity. A large number of genes related to the AHL-type 1 ( ahyI , ahyR ), LuxS-type 2 ( luxS , pfs , metEHK , litR , luxOQU ) and QseBC-type 3 ( qseB , qseC ) autoinducer systems were also identified. As a result of the expression of the ahyI gene in Escherichia coli BL21 (DE3), combined UPLC-MS/MS profiling led to the identification of several new N-acyl-homoserine lactone compounds synthesized by AhyI. This genomic analysis determined the comprehensive QS systems of A. hydrophila , which might provide novel information regarding the mechanisms of virulence signatures correlated with QS." @default.
• W3088393729 created "2020-10-01" @default.
• W3088393729 creator A5004917663 @default.
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• W3088393729 creator A5080148428 @default.
• W3088393729 date "2020-09-23" @default.
• W3088393729 modified "2023-10-10" @default.
• W3088393729 title "Complete genome sequence of fish-pathogenic Aeromonas hydrophila HX-3 and a comparative analysis: insights into virulence factors and quorum sensing" @default.
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• W3088393729 doi "https://doi.org/10.1038/s41598-020-72484-8" @default.
• W3088393729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7512022" @default.
• W3088393729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32968153" @default.

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