FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088396153> ?p ?o ?g. }

• W3088396153 endingPage "e0238748" @default.
• W3088396153 startingPage "e0238748" @default.
• W3088396153 abstract "Antenatal progesterone prevents preterm birth (PTB) in women with a short cervix or prior PTB in daily vaginal or weekly injectable formulations, respectively. Neither has been tested for the indication of maternal HIV, which is associated with an elevated risk of PTB. The Vaginal Progesterone (VP) Trial was a pilot feasibility study of VP to prevent HIV-related PTB in Lusaka, Zambia. Using mixed methods, we concurrently evaluated the acceptability of the trial and the study product among participants. Over a 1-year period, we enrolled 140 pregnant women living with HIV into a double-masked, placebo-controlled, randomized trial of daily self-administered VP or placebo. We administered an endline questionnaire to all participants and conducted in-depth interviews with 30 participants to assess barriers and facilitators to uptake and retention in the trial and to study product adherence. All interviews were audiotaped, transcribed, translated into English as needed, and independently coded by two analysts to capture emerging themes. Of 131 participants who completed the questionnaire, 128 (98%) reported that nothing was difficult when asked the hardest part about using the study product. When given a hypothetical choice between vaginal and injectable progesterone, 97 (74%) chose vaginal, 31 (24%) injectable, and 3 (2%) stated no preference. Most interviewees reported no difficulties with using the study product; others cited minor side effects and surmountable challenges. Strategies that supported adherence included setting alarms, aligning dosing with antiretrovirals, receiving encouragement from friends and family, sensing a benefit to their unborn baby, and positive feedback from study staff. Participants who reported preference of a vaginal medication over injectable described familiarity with the vaginal product, a fear of needles and resulting pain, and inconvenience of a weekly clinic visit. Those who would prefer weekly injections cited fewer doses to remember. Perceived barriers to study participation included mistrust about the motivations behind research, suspicion of Satanism, and futility or possible harm from a placebo. We report key influences on acceptability of a randomized trial of VP to prevent PTB among HIV-infected women in Zambia, which should inform methods to promote uptake, adherence, and retention in a full-scale trial." @default.
• W3088396153 created "2020-10-01" @default.
• W3088396153 creator A5011310403 @default.
• W3088396153 creator A5017612727 @default.
• W3088396153 creator A5019896304 @default.
• W3088396153 creator A5037004277 @default.
• W3088396153 creator A5045496203 @default.
• W3088396153 creator A5072350868 @default.
• W3088396153 creator A5072543117 @default.
• W3088396153 creator A5080702174 @default.
• W3088396153 creator A5088974619 @default.
• W3088396153 creator A5012029060 @default.
• W3088396153 date "2020-09-24" @default.
• W3088396153 modified "2023-09-25" @default.
• W3088396153 title "Acceptability of a trial of vaginal progesterone for the prevention of preterm birth among HIV-infected women in Lusaka, Zambia: A mixed methods study" @default.
• W3088396153 cites W1973698029 @default.
• W3088396153 cites W2020392532 @default.
• W3088396153 cites W2022213850 @default.
• W3088396153 cites W2044369525 @default.
• W3088396153 cites W2048351645 @default.
• W3088396153 cites W2056961960 @default.
• W3088396153 cites W2062861516 @default.
• W3088396153 cites W2071908261 @default.
• W3088396153 cites W2098160568 @default.
• W3088396153 cites W2098609919 @default.
• W3088396153 cites W2101578400 @default.
• W3088396153 cites W2120723986 @default.
• W3088396153 cites W2129660502 @default.
• W3088396153 cites W2130892091 @default.
• W3088396153 cites W2144285624 @default.
• W3088396153 cites W2162453519 @default.
• W3088396153 cites W2174060479 @default.
• W3088396153 cites W2341072683 @default.
• W3088396153 cites W2411936287 @default.
• W3088396153 cites W2764053313 @default.
• W3088396153 cites W2768866915 @default.
• W3088396153 cites W2899173353 @default.
• W3088396153 cites W3003633750 @default.
• W3088396153 doi "https://doi.org/10.1371/journal.pone.0238748" @default.
• W3088396153 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7514015" @default.
• W3088396153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32970697" @default.
• W3088396153 hasPublicationYear "2020" @default.
• W3088396153 type Work @default.
• W3088396153 sameAs 3088396153 @default.
• W3088396153 citedByCount "2" @default.
• W3088396153 countsByYear W30883961532021 @default.
• W3088396153 crossrefType "journal-article" @default.
• W3088396153 hasAuthorship W3088396153A5011310403 @default.
• W3088396153 hasAuthorship W3088396153A5012029060 @default.
• W3088396153 hasAuthorship W3088396153A5017612727 @default.
• W3088396153 hasAuthorship W3088396153A5019896304 @default.
• W3088396153 hasAuthorship W3088396153A5037004277 @default.
• W3088396153 hasAuthorship W3088396153A5045496203 @default.
• W3088396153 hasAuthorship W3088396153A5072350868 @default.
• W3088396153 hasAuthorship W3088396153A5072543117 @default.
• W3088396153 hasAuthorship W3088396153A5080702174 @default.
• W3088396153 hasAuthorship W3088396153A5088974619 @default.
• W3088396153 hasBestOaLocation W30883961531 @default.
• W3088396153 hasConcept C126322002 @default.
• W3088396153 hasConcept C131872663 @default.
• W3088396153 hasConcept C142724271 @default.
• W3088396153 hasConcept C168563851 @default.
• W3088396153 hasConcept C204787440 @default.
• W3088396153 hasConcept C27081682 @default.
• W3088396153 hasConcept C29456083 @default.
• W3088396153 hasConcept C3013748606 @default.
• W3088396153 hasConcept C512399662 @default.
• W3088396153 hasConcept C71924100 @default.
• W3088396153 hasConceptScore W3088396153C126322002 @default.
• W3088396153 hasConceptScore W3088396153C131872663 @default.
• W3088396153 hasConceptScore W3088396153C142724271 @default.
• W3088396153 hasConceptScore W3088396153C168563851 @default.
• W3088396153 hasConceptScore W3088396153C204787440 @default.
• W3088396153 hasConceptScore W3088396153C27081682 @default.
• W3088396153 hasConceptScore W3088396153C29456083 @default.
• W3088396153 hasConceptScore W3088396153C3013748606 @default.
• W3088396153 hasConceptScore W3088396153C512399662 @default.
• W3088396153 hasConceptScore W3088396153C71924100 @default.
• W3088396153 hasIssue "9" @default.
• W3088396153 hasLocation W30883961531 @default.
• W3088396153 hasLocation W30883961532 @default.
• W3088396153 hasLocation W30883961533 @default.
• W3088396153 hasOpenAccess W3088396153 @default.
• W3088396153 hasPrimaryLocation W30883961531 @default.
• W3088396153 hasRelatedWork W2052539084 @default.
• W3088396153 hasRelatedWork W2235574018 @default.
• W3088396153 hasRelatedWork W2507295142 @default.
• W3088396153 hasRelatedWork W2789448498 @default.
• W3088396153 hasRelatedWork W2953633878 @default.
• W3088396153 hasRelatedWork W2989921235 @default.
• W3088396153 hasRelatedWork W3159250744 @default.
• W3088396153 hasRelatedWork W4233016836 @default.
• W3088396153 hasRelatedWork W4292236216 @default.
• W3088396153 hasRelatedWork W2083697902 @default.
• W3088396153 hasVolume "15" @default.
• W3088396153 isParatext "false" @default.
• W3088396153 isRetracted "false" @default.
• W3088396153 magId "3088396153" @default.

• next