FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088402833> ?p ?o ?g. }

• W3088402833 endingPage "923" @default.
• W3088402833 startingPage "923" @default.
• W3088402833 abstract "Stimulating the patient’s immune system represents a promising therapeutic strategy to fight cancer. However, low immunogenicity of the tumor cells within an immune suppressive milieu often leads to weak anti-tumor immune responses. Additionally, the immune system may be impaired by accompanying aggressive chemotherapies. We show that mitoxantrone, bound to superparamagnetic iron oxide nanoparticles (SPIONs) as the transport system, can be magnetically accumulated in adherent HT-29 colon carcinoma cells, thereby inducing the same cell death phenotype as its soluble counterpart, a chemotherapeutic agent and prototypic inductor of immunogenic cell death. The nanoparticle-loaded drug induces cell cycle stop, apoptosis and secondary necrosis in a dose- and time-dependent manner comparable to the free drug. Cell death was accompanied by the release of interleukin-8 and damage-associated molecular patterns (DAMPs) such as HSP70 and ATP, which fostered chemotactic migration of monocytes and maturation of dendritic cells. We furthermore ensured absence of endotoxin contaminations and compatibility with erythrocytes and platelets and investigated the influence on plasma coagulation in vitro. Summarizing, with magnetic enrichment, mitoxantrone can be accumulated at the desired place, sparing healthy peripheral cells and tissues, such as immune cells. Conserving immune competence in cancer patients in the future might allow combined therapeutic approaches with immune therapies (e.g., checkpoint inhibitors)." @default.
• W3088402833 created "2020-10-01" @default.
• W3088402833 creator A5012400250 @default.
• W3088402833 creator A5025954774 @default.
• W3088402833 creator A5030709807 @default.
• W3088402833 creator A5037283652 @default.
• W3088402833 creator A5037644505 @default.
• W3088402833 creator A5038138482 @default.
• W3088402833 creator A5052837479 @default.
• W3088402833 creator A5088733456 @default.
• W3088402833 creator A5090202352 @default.
• W3088402833 creator A5090820233 @default.
• W3088402833 date "2020-09-27" @default.
• W3088402833 modified "2023-10-12" @default.
• W3088402833 title "Mitoxantrone-Loaded Nanoparticles for Magnetically Controlled Tumor Therapy–Induction of Tumor Cell Death, Release of Danger Signals and Activation of Immune Cells" @default.
• W3088402833 cites W1546909751 @default.
• W3088402833 cites W1591392487 @default.
• W3088402833 cites W1868820697 @default.
• W3088402833 cites W1980264362 @default.
• W3088402833 cites W1982861164 @default.
• W3088402833 cites W1991189794 @default.
• W3088402833 cites W1994345724 @default.
• W3088402833 cites W2005717890 @default.
• W3088402833 cites W2016612145 @default.
• W3088402833 cites W2049323462 @default.
• W3088402833 cites W2049553585 @default.
• W3088402833 cites W2049581120 @default.
• W3088402833 cites W2052078062 @default.
• W3088402833 cites W2058676815 @default.
• W3088402833 cites W2070003597 @default.
• W3088402833 cites W2079142824 @default.
• W3088402833 cites W2094623622 @default.
• W3088402833 cites W2142300779 @default.
• W3088402833 cites W2143328804 @default.
• W3088402833 cites W2150027863 @default.
• W3088402833 cites W2150633526 @default.
• W3088402833 cites W2163252162 @default.
• W3088402833 cites W2166910978 @default.
• W3088402833 cites W2168760258 @default.
• W3088402833 cites W2264494863 @default.
• W3088402833 cites W2328702071 @default.
• W3088402833 cites W2330734832 @default.
• W3088402833 cites W2401293529 @default.
• W3088402833 cites W2405675635 @default.
• W3088402833 cites W2410849341 @default.
• W3088402833 cites W2412051818 @default.
• W3088402833 cites W2412080912 @default.
• W3088402833 cites W2436942341 @default.
• W3088402833 cites W2509450930 @default.
• W3088402833 cites W2515854919 @default.
• W3088402833 cites W2517065977 @default.
• W3088402833 cites W2550375380 @default.
• W3088402833 cites W2559382297 @default.
• W3088402833 cites W2560367415 @default.
• W3088402833 cites W267664099 @default.
• W3088402833 cites W2763635548 @default.
• W3088402833 cites W2766860384 @default.
• W3088402833 cites W2770810616 @default.
• W3088402833 cites W2783717670 @default.
• W3088402833 cites W2799640745 @default.
• W3088402833 cites W2802834278 @default.
• W3088402833 cites W2809811258 @default.
• W3088402833 cites W2891359906 @default.
• W3088402833 cites W2892047621 @default.
• W3088402833 cites W2894892175 @default.
• W3088402833 cites W2903595255 @default.
• W3088402833 cites W2913737557 @default.
• W3088402833 cites W2917058676 @default.
• W3088402833 cites W3011642937 @default.
• W3088402833 cites W3048502572 @default.
• W3088402833 doi "https://doi.org/10.3390/pharmaceutics12100923" @default.
• W3088402833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7599695" @default.
• W3088402833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32992645" @default.
• W3088402833 hasPublicationYear "2020" @default.
• W3088402833 type Work @default.
• W3088402833 sameAs 3088402833 @default.
• W3088402833 citedByCount "6" @default.
• W3088402833 countsByYear W30884028332021 @default.
• W3088402833 countsByYear W30884028332022 @default.
• W3088402833 countsByYear W30884028332023 @default.
• W3088402833 crossrefType "journal-article" @default.
• W3088402833 hasAuthorship W3088402833A5012400250 @default.
• W3088402833 hasAuthorship W3088402833A5025954774 @default.
• W3088402833 hasAuthorship W3088402833A5030709807 @default.
• W3088402833 hasAuthorship W3088402833A5037283652 @default.
• W3088402833 hasAuthorship W3088402833A5037644505 @default.
• W3088402833 hasAuthorship W3088402833A5038138482 @default.
• W3088402833 hasAuthorship W3088402833A5052837479 @default.
• W3088402833 hasAuthorship W3088402833A5088733456 @default.
• W3088402833 hasAuthorship W3088402833A5090202352 @default.
• W3088402833 hasAuthorship W3088402833A5090820233 @default.
• W3088402833 hasBestOaLocation W30884028331 @default.
• W3088402833 hasConcept C121608353 @default.
• W3088402833 hasConcept C126322002 @default.
• W3088402833 hasConcept C185592680 @default.
• W3088402833 hasConcept C190283241 @default.
• W3088402833 hasConcept C203014093 @default.
• W3088402833 hasConcept C2776107976 @default.

• next