Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088403385> ?p ?o ?g. }
- W3088403385 abstract "Immunotherapies revolutionized cancer treatment by harnessing the immune system to target cancer cells. However, most patients are resistant to immunotherapies and the mechanisms underlying this resistant is still poorly understood. Here, we report that overexpression of BMP7, a member of the TGFB superfamily, represents a mechanism for resistance to anti-PD1 therapy in preclinical models and in patients with disease progression while on immunotherapies. BMP7 secreted by tumor cells acts on macrophages and CD4+ T cells in the tumor microenvironment, inhibiting MAPK14 expression and impairing pro-inflammatory responses. Knockdown of BMP7 or its neutralization via follistatin in combination with anti-PD1 re-sensitizes resistant tumors to immunotherapies. Thus, we identify the BMP7 signaling pathway as a potential immunotherapeutic target in cancer." @default.
- W3088403385 created "2020-10-01" @default.
- W3088403385 creator A5011678003 @default.
- W3088403385 creator A5013938672 @default.
- W3088403385 creator A5016873916 @default.
- W3088403385 creator A5018427757 @default.
- W3088403385 creator A5018954266 @default.
- W3088403385 creator A5025917226 @default.
- W3088403385 creator A5033798832 @default.
- W3088403385 creator A5036956658 @default.
- W3088403385 creator A5048517627 @default.
- W3088403385 creator A5063896466 @default.
- W3088403385 creator A5066698956 @default.
- W3088403385 creator A5066845543 @default.
- W3088403385 creator A5071785687 @default.
- W3088403385 creator A5073051489 @default.
- W3088403385 creator A5073501391 @default.
- W3088403385 creator A5082498438 @default.
- W3088403385 creator A5085763839 @default.
- W3088403385 creator A5086389738 @default.
- W3088403385 date "2020-09-24" @default.
- W3088403385 modified "2023-10-13" @default.
- W3088403385 title "Bone morphogenetic protein 7 promotes resistance to immunotherapy" @default.
- W3088403385 cites W1534131820 @default.
- W3088403385 cites W1562926120 @default.
- W3088403385 cites W1609684706 @default.
- W3088403385 cites W1636126405 @default.
- W3088403385 cites W1884084176 @default.
- W3088403385 cites W1923387937 @default.
- W3088403385 cites W1966022628 @default.
- W3088403385 cites W1966175518 @default.
- W3088403385 cites W1966258390 @default.
- W3088403385 cites W1970224079 @default.
- W3088403385 cites W1975792673 @default.
- W3088403385 cites W1977424022 @default.
- W3088403385 cites W1979340580 @default.
- W3088403385 cites W1981039997 @default.
- W3088403385 cites W1982785554 @default.
- W3088403385 cites W1989722096 @default.
- W3088403385 cites W1996790178 @default.
- W3088403385 cites W1998881894 @default.
- W3088403385 cites W2007805771 @default.
- W3088403385 cites W2013782861 @default.
- W3088403385 cites W2020670165 @default.
- W3088403385 cites W2022398608 @default.
- W3088403385 cites W2026861011 @default.
- W3088403385 cites W2030681935 @default.
- W3088403385 cites W2032731042 @default.
- W3088403385 cites W2036734848 @default.
- W3088403385 cites W2040083002 @default.
- W3088403385 cites W2042336339 @default.
- W3088403385 cites W2047265596 @default.
- W3088403385 cites W2048217255 @default.
- W3088403385 cites W2056048839 @default.
- W3088403385 cites W2058556985 @default.
- W3088403385 cites W2062654433 @default.
- W3088403385 cites W2062892166 @default.
- W3088403385 cites W2065165253 @default.
- W3088403385 cites W2065371029 @default.
- W3088403385 cites W2068480471 @default.
- W3088403385 cites W2070166913 @default.
- W3088403385 cites W2071153998 @default.
- W3088403385 cites W2077709181 @default.
- W3088403385 cites W2080659668 @default.
- W3088403385 cites W2084472730 @default.
- W3088403385 cites W2086769750 @default.
- W3088403385 cites W2088380402 @default.
- W3088403385 cites W2090673274 @default.
- W3088403385 cites W2091596054 @default.
- W3088403385 cites W2092233035 @default.
- W3088403385 cites W2093441468 @default.
- W3088403385 cites W2093954363 @default.
- W3088403385 cites W2094900684 @default.
- W3088403385 cites W2108674671 @default.
- W3088403385 cites W2112277796 @default.
- W3088403385 cites W2126242978 @default.
- W3088403385 cites W2146453887 @default.
- W3088403385 cites W2149444208 @default.
- W3088403385 cites W2151989714 @default.
- W3088403385 cites W2160834915 @default.
- W3088403385 cites W2165946348 @default.
- W3088403385 cites W2180481128 @default.
- W3088403385 cites W2253234903 @default.
- W3088403385 cites W2301933375 @default.
- W3088403385 cites W2413732961 @default.
- W3088403385 cites W2468544772 @default.
- W3088403385 cites W2551184514 @default.
- W3088403385 cites W2552643092 @default.
- W3088403385 cites W2613990808 @default.
- W3088403385 cites W2751506562 @default.
- W3088403385 cites W2883435196 @default.
- W3088403385 cites W425633012 @default.
- W3088403385 cites W4313335068 @default.
- W3088403385 cites W2135004670 @default.
- W3088403385 doi "https://doi.org/10.1038/s41467-020-18617-z" @default.
- W3088403385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7519103" @default.
- W3088403385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32973129" @default.
- W3088403385 hasPublicationYear "2020" @default.
- W3088403385 type Work @default.
- W3088403385 sameAs 3088403385 @default.