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• W3088405412 abstract "Analytical formulas for effective drift, diffusivity, run times, and run lengths are derived for an intracellular transport system consisting of a cargo attached to two cooperative but not identical molecular motors (for example, kinesin-1 and kinesin-2) which can each attach and detach from a microtubule. The dynamics of the motor and cargo in each phase are governed by stochastic differential equations, and the switching rates depend on the spatial configuration of the motor and cargo. This system is analyzed in a limit where the detached motors have faster dynamics than the cargo, which in turn has faster dynamics than the attached motors. The attachment and detachment rates are also taken to be slow relative to the spatial dynamics. Through an application of iterated stochastic averaging to this system, and the use of renewal-reward theory to stitch together the progress within each switching phase, we obtain explicit analytical expressions for the effective drift, diffusivity, and processivity of the motor-cargo system. Our approach accounts in particular for jumps in motor-cargo position that occur during attachment and detachment events, as the cargo tracking variable makes a rapid adjustment due to the averaged fast scales. The asymptotic formulas are in generally good agreement with direct stochastic simulations of the detailed model based on experimental parameters for various pairings of kinesin-1 and kinesin-2 under assisting, hindering, or no load." @default.
• W3088405412 created "2020-10-01" @default.
• W3088405412 creator A5009337258 @default.
• W3088405412 creator A5009642764 @default.
• W3088405412 creator A5065108569 @default.
• W3088405412 date "2020-09-21" @default.
• W3088405412 modified "2023-10-09" @default.
• W3088405412 title "Effective behavior of cooperative and nonidentical molecular motors" @default.
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• W3088405412 cites W1597440644 @default.
• W3088405412 cites W1793700680 @default.
• W3088405412 cites W1963863239 @default.
• W3088405412 cites W1966086662 @default.
• W3088405412 cites W1969461150 @default.
• W3088405412 cites W1970866062 @default.
• W3088405412 cites W1980819945 @default.
• W3088405412 cites W1986869356 @default.
• W3088405412 cites W1986922416 @default.
• W3088405412 cites W1989729787 @default.
• W3088405412 cites W1993453384 @default.
• W3088405412 cites W1994697081 @default.
• W3088405412 cites W1996615272 @default.
• W3088405412 cites W1997240025 @default.
• W3088405412 cites W2005698300 @default.
• W3088405412 cites W2010937504 @default.
• W3088405412 cites W2013022489 @default.
• W3088405412 cites W2014965368 @default.
• W3088405412 cites W2019021472 @default.
• W3088405412 cites W2019341264 @default.
• W3088405412 cites W2021688560 @default.
• W3088405412 cites W2026245994 @default.
• W3088405412 cites W2026568058 @default.
• W3088405412 cites W2030737079 @default.
• W3088405412 cites W2040456801 @default.
• W3088405412 cites W2042667151 @default.
• W3088405412 cites W2043727919 @default.
• W3088405412 cites W2044730950 @default.
• W3088405412 cites W2045012220 @default.
• W3088405412 cites W2045314223 @default.
• W3088405412 cites W2048921995 @default.
• W3088405412 cites W2051816565 @default.
• W3088405412 cites W2052192720 @default.
• W3088405412 cites W2056822891 @default.
• W3088405412 cites W2072614467 @default.
• W3088405412 cites W2078056153 @default.
• W3088405412 cites W2083577393 @default.
• W3088405412 cites W2089618169 @default.
• W3088405412 cites W2093684011 @default.
• W3088405412 cites W2100561868 @default.
• W3088405412 cites W2103890279 @default.
• W3088405412 cites W2105182047 @default.
• W3088405412 cites W2105881298 @default.
• W3088405412 cites W2109362162 @default.
• W3088405412 cites W2114220612 @default.
• W3088405412 cites W2119818636 @default.
• W3088405412 cites W2120061905 @default.
• W3088405412 cites W2129310517 @default.
• W3088405412 cites W2134852050 @default.
• W3088405412 cites W2137871406 @default.
• W3088405412 cites W2158190317 @default.
• W3088405412 cites W2158671383 @default.
• W3088405412 cites W2160132214 @default.
• W3088405412 cites W2166454051 @default.
• W3088405412 cites W2168701582 @default.
• W3088405412 cites W2170121166 @default.
• W3088405412 cites W2285801557 @default.
• W3088405412 cites W2326691741 @default.
• W3088405412 cites W2464036996 @default.
• W3088405412 cites W2494311810 @default.
• W3088405412 cites W2583253518 @default.
• W3088405412 cites W2620883559 @default.
• W3088405412 cites W2737817395 @default.
• W3088405412 cites W2741288318 @default.
• W3088405412 cites W2747063405 @default.
• W3088405412 cites W2782345288 @default.
• W3088405412 cites W2802575321 @default.
• W3088405412 cites W2807694406 @default.
• W3088405412 cites W2899873549 @default.
• W3088405412 cites W2914041924 @default.
• W3088405412 cites W2937336263 @default.
• W3088405412 cites W2963859695 @default.
• W3088405412 cites W2964101820 @default.
• W3088405412 cites W3098670159 @default.
• W3088405412 cites W4245280614 @default.
• W3088405412 cites W4253281475 @default.
• W3088405412 cites W4298313869 @default.
• W3088405412 cites W4300140424 @default.
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• W3088405412 doi "https://doi.org/10.1007/s40687-020-00230-7" @default.
• W3088405412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8049358" @default.
• W3088405412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33870090" @default.
• W3088405412 hasPublicationYear "2020" @default.
• W3088405412 type Work @default.
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