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- W3088405549 abstract "Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) placental progenitor program. The inner cell mass arises from inner cells during subsequent developmental stages and comprises precursor cells of the embryo proper and yolk sac1. Recent gene-expression analyses suggest that the mechanisms that regulate early lineage specification in the mouse may differ in other mammals, including human2-5 and cow6. Here we show the evolutionary conservation of a molecular cascade that initiates TE segregation in human, cow and mouse embryos. At the morula stage, outer cells acquire an apical-basal cell polarity, with expression of atypical protein kinase C (aPKC) at the contact-free domain, nuclear expression of Hippo signalling pathway effectors and restricted expression of TE-associated factors such as GATA3, which suggests initiation of a TE program. Furthermore, we demonstrate that inhibition of aPKC by small-molecule pharmacological modulation or Trim-Away protein depletion impairs TE initiation at the morula stage. Our comparative embryology analysis provides insights into early lineage specification and suggests that a similar mechanism initiates a TE program in human, cow and mouse embryos." @default.
- W3088405549 created "2020-10-01" @default.
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- W3088405549 date "2020-09-23" @default.
- W3088405549 modified "2023-10-10" @default.
- W3088405549 title "Initiation of a conserved trophectoderm program in human, cow and mouse embryos" @default.
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- W3088405549 doi "https://doi.org/10.1038/s41586-020-2759-x" @default.
- W3088405549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7116563" @default.
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- W3088405549 hasPublicationYear "2020" @default.
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