FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088409510> ?p ?o ?g. }

• W3088409510 endingPage "108003" @default.
• W3088409510 startingPage "108003" @default.
• W3088409510 abstract "Dermatophagoides farinae, an important pathogen, has multiple allergens. However, their expression under physiological conditions are not understood. Our previous RNA-seq showed that allergens of D. farinae were up-regulated under temperature stress, implying that they may be involved in stress response. Here, we performed a comprehensive study. qRT-PCR detection indicated that 26 of the 34 allergens showed differential expression. Der f1 had the most abundant basic expression quantity. Der f 28.0201 (HSP70) and Der f3 had the same regulation pattern in 9 highly expressed transcripts, which only up-regulated at 41 °C and 43 °C, but Der f 28.0201 showed stronger regulation than Der f 3 (19.88-fold vs 6.02-fold). Whereas Der f 1, 2, 7, 21, 22, 27, and 30 were up-regulated under both heat and cold stress, and Der f 27 showed the strongest regulation ability among them. Der f 27 showed more significant up-regulation than Der f 28.0201 under heat stress (23.59-fold vs 19.88-fold), and Der f27 had more obvious up-regulation under cold than heat stress (30.70-fold vs 23.59-fold). The expression of Der f 27, 28.0201 and 1, and D. farinae survival rates significantly decreased following RNAi, indicating the upregulation of these allergens under temperature stress conferred thermo-tolerance or cold-tolerance to D. farinae. In this study, we described for the first time that these allergens have temperature-stress response functions. This new scientific discovery has important clinical value for revealing the more frequent and serious allergic diseases caused by D. farinae during the change of seasons." @default.
• W3088409510 created "2020-10-01" @default.
• W3088409510 creator A5009083614 @default.
• W3088409510 creator A5013647276 @default.
• W3088409510 creator A5087867428 @default.
• W3088409510 date "2020-11-01" @default.
• W3088409510 modified "2023-09-24" @default.
• W3088409510 title "Temperature stress response: A novel important function of Dermatophagoides farinae allergens" @default.
• W3088409510 cites W11573804 @default.
• W3088409510 cites W1515226983 @default.
• W3088409510 cites W1533509265 @default.
• W3088409510 cites W1969123667 @default.
• W3088409510 cites W1969197272 @default.
• W3088409510 cites W1983108385 @default.
• W3088409510 cites W1994534886 @default.
• W3088409510 cites W1994917262 @default.
• W3088409510 cites W2004903929 @default.
• W3088409510 cites W2031473217 @default.
• W3088409510 cites W2035538568 @default.
• W3088409510 cites W2038226520 @default.
• W3088409510 cites W2047131301 @default.
• W3088409510 cites W2054386434 @default.
• W3088409510 cites W2065034448 @default.
• W3088409510 cites W2106144226 @default.
• W3088409510 cites W2107277218 @default.
• W3088409510 cites W2107962824 @default.
• W3088409510 cites W2117139404 @default.
• W3088409510 cites W2120544927 @default.
• W3088409510 cites W2125983617 @default.
• W3088409510 cites W2130711300 @default.
• W3088409510 cites W2138408942 @default.
• W3088409510 cites W2164390562 @default.
• W3088409510 cites W2166760112 @default.
• W3088409510 cites W2325799764 @default.
• W3088409510 cites W2524345511 @default.
• W3088409510 cites W2606426472 @default.
• W3088409510 cites W2608136796 @default.
• W3088409510 cites W2887471685 @default.
• W3088409510 cites W2900159171 @default.
• W3088409510 cites W2935994309 @default.
• W3088409510 cites W2951551586 @default.
• W3088409510 cites W2952069795 @default.
• W3088409510 cites W2970278015 @default.
• W3088409510 cites W2980464900 @default.
• W3088409510 cites W2994080166 @default.
• W3088409510 cites W4230645356 @default.
• W3088409510 cites W773301290 @default.
• W3088409510 cites W3152185625 @default.
• W3088409510 doi "https://doi.org/10.1016/j.exppara.2020.108003" @default.
• W3088409510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32980317" @default.
• W3088409510 hasPublicationYear "2020" @default.
• W3088409510 type Work @default.
• W3088409510 sameAs 3088409510 @default.
• W3088409510 citedByCount "2" @default.
• W3088409510 countsByYear W30884095102021 @default.
• W3088409510 countsByYear W30884095102022 @default.
• W3088409510 crossrefType "journal-article" @default.
• W3088409510 hasAuthorship W3088409510A5009083614 @default.
• W3088409510 hasAuthorship W3088409510A5013647276 @default.
• W3088409510 hasAuthorship W3088409510A5087867428 @default.
• W3088409510 hasConcept C104317684 @default.
• W3088409510 hasConcept C127561419 @default.
• W3088409510 hasConcept C14036430 @default.
• W3088409510 hasConcept C140793950 @default.
• W3088409510 hasConcept C153911025 @default.
• W3088409510 hasConcept C166703698 @default.
• W3088409510 hasConcept C203014093 @default.
• W3088409510 hasConcept C205260736 @default.
• W3088409510 hasConcept C207480886 @default.
• W3088409510 hasConcept C2780510475 @default.
• W3088409510 hasConcept C2987418964 @default.
• W3088409510 hasConcept C55493867 @default.
• W3088409510 hasConcept C67705224 @default.
• W3088409510 hasConcept C68991219 @default.
• W3088409510 hasConcept C86803240 @default.
• W3088409510 hasConcept C95444343 @default.
• W3088409510 hasConceptScore W3088409510C104317684 @default.
• W3088409510 hasConceptScore W3088409510C127561419 @default.
• W3088409510 hasConceptScore W3088409510C14036430 @default.
• W3088409510 hasConceptScore W3088409510C140793950 @default.
• W3088409510 hasConceptScore W3088409510C153911025 @default.
• W3088409510 hasConceptScore W3088409510C166703698 @default.
• W3088409510 hasConceptScore W3088409510C203014093 @default.
• W3088409510 hasConceptScore W3088409510C205260736 @default.
• W3088409510 hasConceptScore W3088409510C207480886 @default.
• W3088409510 hasConceptScore W3088409510C2780510475 @default.
• W3088409510 hasConceptScore W3088409510C2987418964 @default.
• W3088409510 hasConceptScore W3088409510C55493867 @default.
• W3088409510 hasConceptScore W3088409510C67705224 @default.
• W3088409510 hasConceptScore W3088409510C68991219 @default.
• W3088409510 hasConceptScore W3088409510C86803240 @default.
• W3088409510 hasConceptScore W3088409510C95444343 @default.
• W3088409510 hasFunder F4320321001 @default.
• W3088409510 hasLocation W30884095101 @default.
• W3088409510 hasLocation W30884095102 @default.
• W3088409510 hasOpenAccess W3088409510 @default.
• W3088409510 hasPrimaryLocation W30884095101 @default.
• W3088409510 hasRelatedWork W1972847057 @default.

• next