Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088426316> ?p ?o ?g. }
- W3088426316 endingPage "108" @default.
- W3088426316 startingPage "99" @default.
- W3088426316 abstract "Abstract The membrane proximal external region (MPER) of HIV-1 gp41 is targeted by several neutralizing antibodies (NAbs) and is of interest for vaccine design. In this study, we identified novel MPER peptide mimotopes and evaluated their reactivity with HIV + plasma antibodies to characterize the diversity of the immune responses to MPER during natural infection. We utilized phage display technology to generate novel mimotopes that fit antigen-binding sites of MPER NAbs 4E10, 2F5 and Z13. Plasma antibodies from 10 HIV + patients were mapped by phage immunoprecipitation, to identify unique patient MPER binding profiles that were distinct from, and overlapping with, those of MPER NAbs. 4E10 mimotope binding profiles correlated with plasma neutralization of HIV-2/HIV-1 MPER chimeric virus, and with overall plasma neutralization breadth and potency. When administered as vaccines, 4E10 mimotopes elicited low titer NAb responses in mice. HIV mimotopes may be useful for detailed analysis of plasma antibody specificity." @default.
- W3088426316 created "2020-10-01" @default.
- W3088426316 creator A5005601710 @default.
- W3088426316 creator A5006783567 @default.
- W3088426316 creator A5014167073 @default.
- W3088426316 creator A5020862678 @default.
- W3088426316 creator A5041344472 @default.
- W3088426316 creator A5055341298 @default.
- W3088426316 creator A5076550834 @default.
- W3088426316 date "2020-11-01" @default.
- W3088426316 modified "2023-10-17" @default.
- W3088426316 title "Selection and immune recognition of HIV-1 MPER mimotopes" @default.
- W3088426316 cites W1981315958 @default.
- W3088426316 cites W1990152283 @default.
- W3088426316 cites W2006975604 @default.
- W3088426316 cites W2013330052 @default.
- W3088426316 cites W2014071844 @default.
- W3088426316 cites W2025757334 @default.
- W3088426316 cites W2033645653 @default.
- W3088426316 cites W2037488078 @default.
- W3088426316 cites W2045911618 @default.
- W3088426316 cites W2047921952 @default.
- W3088426316 cites W2053127269 @default.
- W3088426316 cites W2058816304 @default.
- W3088426316 cites W2072278974 @default.
- W3088426316 cites W2074179519 @default.
- W3088426316 cites W2083094268 @default.
- W3088426316 cites W2085048408 @default.
- W3088426316 cites W2089766500 @default.
- W3088426316 cites W2095910488 @default.
- W3088426316 cites W2096010144 @default.
- W3088426316 cites W2097594050 @default.
- W3088426316 cites W2102548388 @default.
- W3088426316 cites W2104197131 @default.
- W3088426316 cites W2106197125 @default.
- W3088426316 cites W2109229894 @default.
- W3088426316 cites W2110787025 @default.
- W3088426316 cites W2118545611 @default.
- W3088426316 cites W2126654882 @default.
- W3088426316 cites W2133574456 @default.
- W3088426316 cites W2136489732 @default.
- W3088426316 cites W2137901057 @default.
- W3088426316 cites W2137939749 @default.
- W3088426316 cites W2143585030 @default.
- W3088426316 cites W2152440860 @default.
- W3088426316 cites W2154226508 @default.
- W3088426316 cites W2235599671 @default.
- W3088426316 cites W2515855649 @default.
- W3088426316 cites W2562927971 @default.
- W3088426316 cites W2570553572 @default.
- W3088426316 cites W2756082041 @default.
- W3088426316 cites W4241040961 @default.
- W3088426316 doi "https://doi.org/10.1016/j.virol.2020.06.016" @default.
- W3088426316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32980676" @default.
- W3088426316 hasPublicationYear "2020" @default.
- W3088426316 type Work @default.
- W3088426316 sameAs 3088426316 @default.
- W3088426316 citedByCount "4" @default.
- W3088426316 countsByYear W30884263162022 @default.
- W3088426316 crossrefType "journal-article" @default.
- W3088426316 hasAuthorship W3088426316A5005601710 @default.
- W3088426316 hasAuthorship W3088426316A5006783567 @default.
- W3088426316 hasAuthorship W3088426316A5014167073 @default.
- W3088426316 hasAuthorship W3088426316A5020862678 @default.
- W3088426316 hasAuthorship W3088426316A5041344472 @default.
- W3088426316 hasAuthorship W3088426316A5055341298 @default.
- W3088426316 hasAuthorship W3088426316A5076550834 @default.
- W3088426316 hasBestOaLocation W30884263161 @default.
- W3088426316 hasConcept C104317684 @default.
- W3088426316 hasConcept C154945302 @default.
- W3088426316 hasConcept C159047783 @default.
- W3088426316 hasConcept C203014093 @default.
- W3088426316 hasConcept C2986302931 @default.
- W3088426316 hasConcept C3013748606 @default.
- W3088426316 hasConcept C3018252375 @default.
- W3088426316 hasConcept C41008148 @default.
- W3088426316 hasConcept C54355233 @default.
- W3088426316 hasConcept C70721500 @default.
- W3088426316 hasConcept C81917197 @default.
- W3088426316 hasConcept C86803240 @default.
- W3088426316 hasConcept C8891405 @default.
- W3088426316 hasConceptScore W3088426316C104317684 @default.
- W3088426316 hasConceptScore W3088426316C154945302 @default.
- W3088426316 hasConceptScore W3088426316C159047783 @default.
- W3088426316 hasConceptScore W3088426316C203014093 @default.
- W3088426316 hasConceptScore W3088426316C2986302931 @default.
- W3088426316 hasConceptScore W3088426316C3013748606 @default.
- W3088426316 hasConceptScore W3088426316C3018252375 @default.
- W3088426316 hasConceptScore W3088426316C41008148 @default.
- W3088426316 hasConceptScore W3088426316C54355233 @default.
- W3088426316 hasConceptScore W3088426316C70721500 @default.
- W3088426316 hasConceptScore W3088426316C81917197 @default.
- W3088426316 hasConceptScore W3088426316C86803240 @default.
- W3088426316 hasConceptScore W3088426316C8891405 @default.
- W3088426316 hasFunder F4320306078 @default.
- W3088426316 hasLocation W30884263161 @default.
- W3088426316 hasOpenAccess W3088426316 @default.
- W3088426316 hasPrimaryLocation W30884263161 @default.