FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088431259> ?p ?o ?g. }

• W3088431259 abstract "TDP-43 is an RNA binding protein whose aggregation is a hallmark of the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. TDP-43 loss increases DNA damage and compromises cell viability, but the actual function of TDP-43 in preventing genome instability remains unclear. Here, we show that loss of TDP-43 increases R-loop formation in a transcription-dependent manner and results in DNA replication stress. TDP-43 nucleic-acid binding and self-assembly activities are important in inhibiting R-loop accumulation and preserving normal DNA replication. We also find that TDP-43 cytoplasmic aggregation impairs TDP-43 function in R-loop regulation. Furthermore, increased R-loop accumulation and DNA damage is observed in neurons upon loss of TDP-43. Together, our findings indicate that TDP-43 function and normal protein homeostasis are critical in maintaining genomic stability through a co-transcriptional process that prevents aberrant R-loop accumulation. We propose that the increased R-loop formation and genomic instability associated with TDP-43 loss are linked to the pathogenesis of TDP-43 proteinopathies." @default.
• W3088431259 created "2020-10-01" @default.
• W3088431259 creator A5001615371 @default.
• W3088431259 creator A5020478312 @default.
• W3088431259 creator A5021654867 @default.
• W3088431259 creator A5031550197 @default.
• W3088431259 creator A5035147926 @default.
• W3088431259 creator A5053377280 @default.
• W3088431259 creator A5084793955 @default.
• W3088431259 date "2020-01-01" @default.
• W3088431259 modified "2023-10-16" @default.
• W3088431259 title "TDP-43 dysfunction results in R-loop accumulation and DNA replication defects" @default.
• W3088431259 cites W1525431743 @default.
• W3088431259 cites W1557728494 @default.
• W3088431259 cites W183349502 @default.
• W3088431259 cites W1904847174 @default.
• W3088431259 cites W1965749659 @default.
• W3088431259 cites W1966682365 @default.
• W3088431259 cites W1967932847 @default.
• W3088431259 cites W1968789240 @default.
• W3088431259 cites W1970966311 @default.
• W3088431259 cites W1972011626 @default.
• W3088431259 cites W1975993845 @default.
• W3088431259 cites W1976736675 @default.
• W3088431259 cites W1979937961 @default.
• W3088431259 cites W1982021060 @default.
• W3088431259 cites W1983289953 @default.
• W3088431259 cites W1984145170 @default.
• W3088431259 cites W1992002234 @default.
• W3088431259 cites W2003618511 @default.
• W3088431259 cites W2009743738 @default.
• W3088431259 cites W2013846962 @default.
• W3088431259 cites W2025555587 @default.
• W3088431259 cites W2027720028 @default.
• W3088431259 cites W2031964319 @default.
• W3088431259 cites W2043375872 @default.
• W3088431259 cites W2047292328 @default.
• W3088431259 cites W2058012269 @default.
• W3088431259 cites W2062672822 @default.
• W3088431259 cites W2065140753 @default.
• W3088431259 cites W2065219073 @default.
• W3088431259 cites W2065884484 @default.
• W3088431259 cites W2066952414 @default.
• W3088431259 cites W2069350252 @default.
• W3088431259 cites W2069376224 @default.
• W3088431259 cites W2078166319 @default.
• W3088431259 cites W2078403259 @default.
• W3088431259 cites W2081420723 @default.
• W3088431259 cites W2082172177 @default.
• W3088431259 cites W2091145925 @default.
• W3088431259 cites W2091554459 @default.
• W3088431259 cites W2092646825 @default.
• W3088431259 cites W2094078115 @default.
• W3088431259 cites W2101042581 @default.
• W3088431259 cites W2102622341 @default.
• W3088431259 cites W2104301158 @default.
• W3088431259 cites W2107338709 @default.
• W3088431259 cites W2107455041 @default.
• W3088431259 cites W2119176236 @default.
• W3088431259 cites W2125433175 @default.
• W3088431259 cites W2126569879 @default.
• W3088431259 cites W2128741337 @default.
• W3088431259 cites W2136949432 @default.
• W3088431259 cites W2150523249 @default.
• W3088431259 cites W2154417593 @default.
• W3088431259 cites W2154945114 @default.
• W3088431259 cites W2157450464 @default.
• W3088431259 cites W2160311330 @default.
• W3088431259 cites W2161887614 @default.
• W3088431259 cites W2166434010 @default.
• W3088431259 cites W2187574279 @default.
• W3088431259 cites W2207325914 @default.
• W3088431259 cites W2463453322 @default.
• W3088431259 cites W2481938983 @default.
• W3088431259 cites W2510545519 @default.
• W3088431259 cites W2513764101 @default.
• W3088431259 cites W2521797369 @default.
• W3088431259 cites W2610738034 @default.
• W3088431259 cites W2611449604 @default.
• W3088431259 cites W2617973969 @default.
• W3088431259 cites W2649090908 @default.
• W3088431259 cites W2734373506 @default.
• W3088431259 cites W2735341248 @default.
• W3088431259 cites W2743954317 @default.
• W3088431259 cites W2762278714 @default.
• W3088431259 cites W2765768656 @default.
• W3088431259 cites W2784889917 @default.
• W3088431259 cites W2786688711 @default.
• W3088431259 cites W2807481171 @default.
• W3088431259 cites W2809451128 @default.
• W3088431259 cites W2889676858 @default.
• W3088431259 cites W2900169195 @default.
• W3088431259 cites W2920477154 @default.
• W3088431259 cites W2943828894 @default.
• W3088431259 cites W2944977287 @default.
• W3088431259 cites W2982655986 @default.
• W3088431259 cites W3048305389 @default.
• W3088431259 doi "https://doi.org/10.1242/jcs.244129" @default.
• W3088431259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7648616" @default.
• W3088431259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34005334" @default.

• next