FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088441057> ?p ?o ?g. }

• W3088441057 endingPage "S1075" @default.
• W3088441057 startingPage "S1075" @default.
• W3088441057 abstract "Several systemic anti-cancer therapies, including paclitaxel contain alcohol as a solvent, which may pose a risk to those who drive home after treatment. This study aimed to provide a better understanding of the effect of ethanol diluent on breath alcohol concentration in an Irish population. In this prospective study, patients attending the Oncology Day Unit at Beaumont Hospital were invited to participate on their treatment day. Breath alcohol concentration was measured using the Alcosense™ breathalyser before and after paclitaxel infusion. The primary end-point was the number of patients who were above the legal alcohol threshold for driving in Ireland. Secondary end-points included the exploration of factors that might influence breath alcohol levels. A total of 50 patients were included over a ten month period. Median age was 56 years, 34 (68%) were female. Most (56%) had breast or oesophageal (30%) cancer. The mean BSA was 1.8m2 (range 1.51-2.29 m2). 10 (20%) had metastatic disease including 4 (8%) with hepatic spread. Mean ALT level for the three visits was 26 IU/L (range 7-63 IU/L). The infusion duration was sixty minutes for all patients. Mean paclitaxel dose was 118 mg, mean total amount of ethanol infused was 7.7g. Overall, 27 patients had a detectable breath alcohol level on at least one visit (range 4-11 mcg/100mls of breath). Mean breath alcohol level was 2 mcg/100mls of breath for overall group. A weak correlation was observed between breath alcohol level and total amount of ethanol infused. The maximum breath alcohol level recorded was 11 mcg/100mls of breath, 50% of the statutory limit for the majority of drivers and exceeding the threshold for professional, learner and novice drivers in Ireland.Table:Pts baseline characteristicsDetectable (n=27)Undetectable (n=23)Overall (n=50)Age, median (SD), years48 (10.5)67 (11)56 (13.5)BSA, mean (SD), m21.8 (0.17)1.9 (0.2)1.8 (0.2)Diagnosis, n (%) Breast Oesophageal Other25 (93) 2 (7) -3 (13) 13 (57) 7 (30)28 (56) 15 (30) 7 (14)Metastatic disease, n (%)4 (15)6 (26)10 (20)Taxol dose, mean (SD), mg135 (21.5)98 (14.9)118 (26.6)Total amount of ethanol infused, mean (SD), mg8.8 (1.4)6.4 (0.97)7.7 (1.7)Cycle at baseline, median (SD)3 (2)2 (3.2)2 (2.6) Open table in a new tab . Although definitive conclusions are limited by relatively small numbers, it seems unlikely that weekly paclitaxel infusions pose any significant risk to patients breaching drink driving limits." @default.
• W3088441057 created "2020-10-01" @default.
• W3088441057 creator A5004102701 @default.
• W3088441057 creator A5005311716 @default.
• W3088441057 creator A5009337993 @default.
• W3088441057 creator A5015772179 @default.
• W3088441057 creator A5020956283 @default.
• W3088441057 creator A5039312503 @default.
• W3088441057 creator A5047981365 @default.
• W3088441057 creator A5049599513 @default.
• W3088441057 creator A5062760520 @default.
• W3088441057 creator A5066558926 @default.
• W3088441057 creator A5067642403 @default.
• W3088441057 creator A5073965698 @default.
• W3088441057 date "2020-09-01" @default.
• W3088441057 modified "2023-09-28" @default.
• W3088441057 title "1894P Final results from a prospective study examining exhaled breath alcohol levels following weekly paclitaxel chemotherapy" @default.
• W3088441057 doi "https://doi.org/10.1016/j.annonc.2020.08.1541" @default.
• W3088441057 hasPublicationYear "2020" @default.
• W3088441057 type Work @default.
• W3088441057 sameAs 3088441057 @default.
• W3088441057 citedByCount "0" @default.
• W3088441057 crossrefType "journal-article" @default.
• W3088441057 hasAuthorship W3088441057A5004102701 @default.
• W3088441057 hasAuthorship W3088441057A5005311716 @default.
• W3088441057 hasAuthorship W3088441057A5009337993 @default.
• W3088441057 hasAuthorship W3088441057A5015772179 @default.
• W3088441057 hasAuthorship W3088441057A5020956283 @default.
• W3088441057 hasAuthorship W3088441057A5039312503 @default.
• W3088441057 hasAuthorship W3088441057A5047981365 @default.
• W3088441057 hasAuthorship W3088441057A5049599513 @default.
• W3088441057 hasAuthorship W3088441057A5062760520 @default.
• W3088441057 hasAuthorship W3088441057A5066558926 @default.
• W3088441057 hasAuthorship W3088441057A5067642403 @default.
• W3088441057 hasAuthorship W3088441057A5073965698 @default.
• W3088441057 hasBestOaLocation W30884410571 @default.
• W3088441057 hasConcept C126322002 @default.
• W3088441057 hasConcept C185592680 @default.
• W3088441057 hasConcept C188816634 @default.
• W3088441057 hasConcept C2776694085 @default.
• W3088441057 hasConcept C2777292972 @default.
• W3088441057 hasConcept C2781066024 @default.
• W3088441057 hasConcept C2908647359 @default.
• W3088441057 hasConcept C55493867 @default.
• W3088441057 hasConcept C71924100 @default.
• W3088441057 hasConcept C90924648 @default.
• W3088441057 hasConcept C99454951 @default.
• W3088441057 hasConceptScore W3088441057C126322002 @default.
• W3088441057 hasConceptScore W3088441057C185592680 @default.
• W3088441057 hasConceptScore W3088441057C188816634 @default.
• W3088441057 hasConceptScore W3088441057C2776694085 @default.
• W3088441057 hasConceptScore W3088441057C2777292972 @default.
• W3088441057 hasConceptScore W3088441057C2781066024 @default.
• W3088441057 hasConceptScore W3088441057C2908647359 @default.
• W3088441057 hasConceptScore W3088441057C55493867 @default.
• W3088441057 hasConceptScore W3088441057C71924100 @default.
• W3088441057 hasConceptScore W3088441057C90924648 @default.
• W3088441057 hasConceptScore W3088441057C99454951 @default.
• W3088441057 hasLocation W30884410571 @default.
• W3088441057 hasOpenAccess W3088441057 @default.
• W3088441057 hasPrimaryLocation W30884410571 @default.
• W3088441057 hasRelatedWork W2092900223 @default.
• W3088441057 hasRelatedWork W2135329844 @default.
• W3088441057 hasRelatedWork W2295722933 @default.
• W3088441057 hasRelatedWork W2311734504 @default.
• W3088441057 hasRelatedWork W2371666691 @default.
• W3088441057 hasRelatedWork W2378355431 @default.
• W3088441057 hasRelatedWork W2387021862 @default.
• W3088441057 hasRelatedWork W2417780159 @default.
• W3088441057 hasRelatedWork W2550683515 @default.
• W3088441057 hasRelatedWork W3032577888 @default.
• W3088441057 hasVolume "31" @default.
• W3088441057 isParatext "false" @default.
• W3088441057 isRetracted "false" @default.
• W3088441057 magId "3088441057" @default.
• W3088441057 workType "article" @default.