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- W3088442014 endingPage "1448" @default.
- W3088442014 startingPage "1448" @default.
- W3088442014 abstract "Tularemia is a zoonotic disease caused by Francisella tularensis a small, pleomorphic, facultative intracellular bacterium. In Europe, infections in animals and humans are caused mainly by Francisella tularensis subspecies holarctica. Humans can be exposed to the pathogen directly and indirectly through contact with sick animals, carcasses, mosquitoes and ticks, environmental sources such as contaminated water or soil, and food. So far, F. tularensis subsp. holarctica is the only Francisella species known to cause tularemia in Germany. On the basis of surveillance data, outbreak investigations, and literature, we review herein the epidemiological situation—noteworthy clinical cases next to genetic diversity of F. tularensis subsp. holarctica strains isolated from patients. In the last 15 years, the yearly number of notified cases of tularemia has increased steadily in Germany, suggesting that the disease is re-emerging. By sequencing F. tularensis subsp. holarctica genomes, knowledge has been added to recent findings, completing the picture of genotypic diversity and geographical segregation of Francisella clades in Germany. Here, we also shortly summarize the current knowledge about a new Francisella species (Francisella sp. strain W12-1067) that has been recently identified in Germany. This species is the second Francisella species discovered in Germany." @default.
- W3088442014 created "2020-10-01" @default.
- W3088442014 creator A5010201733 @default.
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- W3088442014 creator A5057665547 @default.
- W3088442014 creator A5083666893 @default.
- W3088442014 date "2020-09-22" @default.
- W3088442014 modified "2023-10-14" @default.
- W3088442014 title "Francisella tularensis Subspecies holarctica and Tularemia in Germany" @default.
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- W3088442014 doi "https://doi.org/10.3390/microorganisms8091448" @default.
- W3088442014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7564102" @default.
- W3088442014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32971773" @default.
- W3088442014 hasPublicationYear "2020" @default.