FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088448357> ?p ?o ?g. }

• W3088448357 endingPage "478" @default.
• W3088448357 startingPage "461" @default.
• W3088448357 abstract "High-risk neuroblastoma (HR-NB) is branded with hematogenous metastasis, relapses, and dismal long-term survival. Intensification of consolidation therapy with tandem/triple autologous stem cell (SC) rescue (with bone marrow [BM]/peripheral blood [PB] CD34+ selection) after myeloablative chemotherapy has improved long-term survival. However, the benefit is limited by the indication of NB cells in CD34+ PBSCs, CD34 expression in NB cells, and the risk of reinfusing NB cancer stem cells (NB CSCs) that could lead to post-transplant relapse. We investigated the association of CD34 surface expression (92 patients) with NB evolution/clinical outcomes. CD34 gene-level status in NB was assessed through RNA-Seq data mining (18 cohorts, n, 3324). Genetic landscape of CD34-expressing NB CSCs (CD133+CD34+) was compared with CD34- CSCs (CD133+CD34-). RNA-seq data revealed equivocal association patterns of CD34 expression with patient survival. Our immunohistochemistry data revealed definite, but rare (mean, 0.73%; range 0.00-7.87%; median, 0.20%) CD34 positivity in NB. CD34+ significantly associated with MYCN amplification (p, 0.003), advanced disease stage (p, 0.016), and progressive disease (PD, p < 0.0009) after clinical therapy. A general high-is-worse tendency was observed in patients with relapsed disease. High CD34+ correlated with poor survival in patients with N-MYC-amplified HR-NB. Gene expression analysis of CD34+-NB CSCs identified significant up (4631) and downmodulation (4678) of genes compared with NB CSCs that lack CD34. IPA recognized the modulation of crucial signaling elements (EMT, stemness maintenance, differentiation, inflammation, clonal expansion, drug resistance, metastasis) that orchestrate NB disease evolution in CD34+ CSCs compared with CD34- CSCs. While the function of CD34 in NB evolution requires further in-depth investigation, careful consideration should be exercised for autologous stem cell rescue with CD34+ selection in NB patients. Graphical abstract." @default.
• W3088448357 created "2020-10-01" @default.
• W3088448357 creator A5001096226 @default.
• W3088448357 creator A5007531008 @default.
• W3088448357 creator A5018397996 @default.
• W3088448357 creator A5086040458 @default.
• W3088448357 date "2020-09-26" @default.
• W3088448357 modified "2023-10-16" @default.
• W3088448357 title "Significance of hematopoietic surface antigen CD34 in neuroblastoma prognosis and the genetic landscape of CD34-expressing neuroblastoma CSCs" @default.
• W3088448357 cites W1101533912 @default.
• W3088448357 cites W1535636977 @default.
• W3088448357 cites W1557333221 @default.
• W3088448357 cites W176189142 @default.
• W3088448357 cites W1897671347 @default.
• W3088448357 cites W1923594999 @default.
• W3088448357 cites W1962389813 @default.
• W3088448357 cites W1972346918 @default.
• W3088448357 cites W1976142372 @default.
• W3088448357 cites W1976210784 @default.
• W3088448357 cites W1981067928 @default.
• W3088448357 cites W2008384166 @default.
• W3088448357 cites W2012687605 @default.
• W3088448357 cites W2015214465 @default.
• W3088448357 cites W2033037904 @default.
• W3088448357 cites W2033108034 @default.
• W3088448357 cites W2039391338 @default.
• W3088448357 cites W2054269923 @default.
• W3088448357 cites W2057614115 @default.
• W3088448357 cites W2060162536 @default.
• W3088448357 cites W2074882068 @default.
• W3088448357 cites W2079636618 @default.
• W3088448357 cites W2087396775 @default.
• W3088448357 cites W2095091399 @default.
• W3088448357 cites W2103357009 @default.
• W3088448357 cites W2106664318 @default.
• W3088448357 cites W2121316920 @default.
• W3088448357 cites W2124185479 @default.
• W3088448357 cites W2126968178 @default.
• W3088448357 cites W2127478952 @default.
• W3088448357 cites W2132154679 @default.
• W3088448357 cites W2132322911 @default.
• W3088448357 cites W2135490889 @default.
• W3088448357 cites W2137017579 @default.
• W3088448357 cites W2144999788 @default.
• W3088448357 cites W2168659791 @default.
• W3088448357 cites W2170436397 @default.
• W3088448357 cites W2171332234 @default.
• W3088448357 cites W2203734769 @default.
• W3088448357 cites W2242711566 @default.
• W3088448357 cites W2265716186 @default.
• W3088448357 cites W2324582862 @default.
• W3088448357 cites W2327522594 @default.
• W3088448357 cites W2396007914 @default.
• W3088448357 cites W2436610849 @default.
• W3088448357 cites W2598921015 @default.
• W3088448357 cites W2730046613 @default.
• W3088448357 cites W2766756296 @default.
• W3088448357 cites W2772873089 @default.
• W3088448357 cites W2782402813 @default.
• W3088448357 cites W2800095326 @default.
• W3088448357 cites W2889470010 @default.
• W3088448357 cites W2889951675 @default.
• W3088448357 cites W2947255681 @default.
• W3088448357 cites W2969033812 @default.
• W3088448357 cites W2981168184 @default.
• W3088448357 cites W2987465273 @default.
• W3088448357 cites W2989897360 @default.
• W3088448357 cites W4251845825 @default.
• W3088448357 cites W53893348 @default.
• W3088448357 doi "https://doi.org/10.1007/s10565-020-09557-x" @default.
• W3088448357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8529858" @default.
• W3088448357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32979173" @default.
• W3088448357 hasPublicationYear "2020" @default.
• W3088448357 type Work @default.
• W3088448357 sameAs 3088448357 @default.
• W3088448357 citedByCount "7" @default.
• W3088448357 countsByYear W30884483572021 @default.
• W3088448357 countsByYear W30884483572022 @default.
• W3088448357 countsByYear W30884483572023 @default.
• W3088448357 crossrefType "journal-article" @default.
• W3088448357 hasAuthorship W3088448357A5001096226 @default.
• W3088448357 hasAuthorship W3088448357A5007531008 @default.
• W3088448357 hasAuthorship W3088448357A5018397996 @default.
• W3088448357 hasAuthorship W3088448357A5086040458 @default.
• W3088448357 hasBestOaLocation W30884483572 @default.
• W3088448357 hasConcept C10205521 @default.
• W3088448357 hasConcept C109159458 @default.
• W3088448357 hasConcept C126322002 @default.
• W3088448357 hasConcept C143998085 @default.
• W3088448357 hasConcept C147483822 @default.
• W3088448357 hasConcept C196166836 @default.
• W3088448357 hasConcept C203014093 @default.
• W3088448357 hasConcept C2780007613 @default.
• W3088448357 hasConcept C28328180 @default.
• W3088448357 hasConcept C502942594 @default.
• W3088448357 hasConcept C54355233 @default.
• W3088448357 hasConcept C71924100 @default.
• W3088448357 hasConcept C86803240 @default.

• next