Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088455384> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W3088455384 endingPage "100201" @default.
- W3088455384 startingPage "100201" @default.
- W3088455384 abstract "To evaluate the clinical efficacy and safety of long-term anti-IgE therapy in patients with severe uncontrolled atopic asthma. In Chelyabinsk from November 2016 47 patients regularly receive omalizumab therapy - 8 men (17.02%) and 39 women (82.98%), the average age was 53.5×10.2 years, the duration of the asthma - 22.7×11.5 years. All patients have associated allergic pathology: allergic rhinitis - 100%, pollinosis - 79.4%, food allergy - 44.1%, atopic dermatitis - 26.5%. The level of total IgE in the blood is from 72 to 787 IU/ml. High sensitization to household (87.2%), epidermal (61.7%), pollen (74.5%) allergens was detected. All patients received basic combination therapy of inhaled corticosteroids and LABA in high doses, 38 (80.85%) additionally took systemic corticosteroids, 26 (55.3%) anti-leukotriene and 16 (34.04%) used tiotropium. For 24 months anti-IgE-therapy there were no severe exacerbation of asthma, there were no hospitalizations, canceled systemic corticosteroids for basic therapy. All patients showed a decrease of daytime (by 88.1%) and night (by 98.2%) symptoms, on 81.9% reduced the need of SABA. Over 2 years of therapy the quality of life improved significantly according to the AST test (5.62×0.91 vs 20.93×2.11, p<0.001) and the ACQ-7 (3.64×0.52 vs 1.22×0.66, p<0.001). 76.6% patients have no symptoms of allergic rhinitis. Improved the lunf function: initially FEV1=63.15×2.9%, after 24 months treatment with omalizumab FEV1=90.21×1.58%, p<0.001." @default.
- W3088455384 created "2020-10-01" @default.
- W3088455384 creator A5040896031 @default.
- W3088455384 creator A5091250849 @default.
- W3088455384 date "2020-08-01" @default.
- W3088455384 modified "2023-09-26" @default.
- W3088455384 title "Effect of 2-year treatment with Omalizumab in severe atopic asthma in real clinical practice" @default.
- W3088455384 doi "https://doi.org/10.1016/j.waojou.2020.100201" @default.
- W3088455384 hasPublicationYear "2020" @default.
- W3088455384 type Work @default.
- W3088455384 sameAs 3088455384 @default.
- W3088455384 citedByCount "0" @default.
- W3088455384 crossrefType "journal-article" @default.
- W3088455384 hasAuthorship W3088455384A5040896031 @default.
- W3088455384 hasAuthorship W3088455384A5091250849 @default.
- W3088455384 hasBestOaLocation W30884553841 @default.
- W3088455384 hasConcept C126322002 @default.
- W3088455384 hasConcept C141105273 @default.
- W3088455384 hasConcept C159654299 @default.
- W3088455384 hasConcept C16005928 @default.
- W3088455384 hasConcept C203014093 @default.
- W3088455384 hasConcept C207480886 @default.
- W3088455384 hasConcept C2776042228 @default.
- W3088455384 hasConcept C2777014857 @default.
- W3088455384 hasConcept C2778329239 @default.
- W3088455384 hasConcept C2778564945 @default.
- W3088455384 hasConcept C71924100 @default.
- W3088455384 hasConcept C90924648 @default.
- W3088455384 hasConceptScore W3088455384C126322002 @default.
- W3088455384 hasConceptScore W3088455384C141105273 @default.
- W3088455384 hasConceptScore W3088455384C159654299 @default.
- W3088455384 hasConceptScore W3088455384C16005928 @default.
- W3088455384 hasConceptScore W3088455384C203014093 @default.
- W3088455384 hasConceptScore W3088455384C207480886 @default.
- W3088455384 hasConceptScore W3088455384C2776042228 @default.
- W3088455384 hasConceptScore W3088455384C2777014857 @default.
- W3088455384 hasConceptScore W3088455384C2778329239 @default.
- W3088455384 hasConceptScore W3088455384C2778564945 @default.
- W3088455384 hasConceptScore W3088455384C71924100 @default.
- W3088455384 hasConceptScore W3088455384C90924648 @default.
- W3088455384 hasIssue "8" @default.
- W3088455384 hasLocation W30884553841 @default.
- W3088455384 hasOpenAccess W3088455384 @default.
- W3088455384 hasPrimaryLocation W30884553841 @default.
- W3088455384 hasRelatedWork W1681555290 @default.
- W3088455384 hasRelatedWork W1925781980 @default.
- W3088455384 hasRelatedWork W2007221846 @default.
- W3088455384 hasRelatedWork W2018443446 @default.
- W3088455384 hasRelatedWork W2080058403 @default.
- W3088455384 hasRelatedWork W2217625724 @default.
- W3088455384 hasRelatedWork W2418399628 @default.
- W3088455384 hasRelatedWork W2738981461 @default.
- W3088455384 hasRelatedWork W2953704332 @default.
- W3088455384 hasRelatedWork W4290085095 @default.
- W3088455384 hasVolume "13" @default.
- W3088455384 isParatext "false" @default.
- W3088455384 isRetracted "false" @default.
- W3088455384 magId "3088455384" @default.
- W3088455384 workType "article" @default.