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• W3088489529 abstract "• Red luminescent porous silicon is used as a carrying matrix for chondroitinase with the aim of enhancing its stability. • Stability of the enzyme loaded onto silicon was enhanced significantly after immobilization. • Cell viability assay proved no toxicity up to 24 hours. • This could make the silicon nanoparticles with red luminescence a useful stabilizer drug delivery vehicle. • An interesting approach to repair spinal cord injuries in future. The bacterial enzyme chondroitinase ABC, which digests extracellular chondroitin sulfate proteoglycans, has been shown to enhance axonal regeneration. However, the utilization of this enzyme as therapeutics is notably restricted due to its thermal instability. Therefore, red luminescent porous silicon that hold promise for potential applications in biological/medical imaging was used as a carrying matrix for chondroitinase with the aim of enhancing its stability. Porous Si nanoparticles were prepared by electrochemical etching of silicon wafers in ethanolic HF solution. The size of nanoparticles (210 nm) and the mean pore diameter (8 −20 nm) were determined using dynamic light scattering and scanning electron microscopy. Purified chondroitinase was then incorporated into the silicon pores. Results revealed similar K m and lower V max value for the immobilized enzyme when compared with the free enzyme. The immobilized chondroitinase exhibited about a 4 fold increase in stability at 37 °C after 50 min. It is likely possible that, the enzyme was protected inside the pores resulted in higher stability. Moreover, porous silicon was seen to be capable of holding the chondroitinase for repeated cyclic tests for three times. The cell viability assay exhibited no significant cytotoxicity for Psi-chondroitinase up to 24 h." @default.
• W3088489529 created "2020-10-01" @default.
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• W3088489529 date "2020-12-01" @default.
• W3088489529 modified "2023-09-24" @default.
• W3088489529 title "Catalytic parameters and thermal stability of chondroitinase ABCI on red porous silicon nanoparticles" @default.
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• W3088489529 doi "https://doi.org/10.1016/j.jbiotec.2020.09.020" @default.
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• W3088489529 hasPublicationYear "2020" @default.
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