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- W3088500806 abstract "Following fertilization, totipotent cells divide to generate two compartments in the early embryo: the inner cell mass (ICM) and trophectoderm (TE). It is only at the 32-64 -cell stage when a clear segregation between the two cell-types is observed, suggesting a ‘T’-shaped model of specification. Here, we examine whether the acquisition of these two states in vitro by nuclear reprogramming share similar dynamics/trajectories. We conducted a comparative parallel multi-omics analysis on cells undergoing reprogramming to Induced pluripotent stem cells (iPSCs) and induced trophoblast stem cells (TSCs), and examined their transcriptome, methylome, chromatin accessibility and activity and genomic stability. Our analysis revealed that cells undergoing reprogramming to pluripotency and TSC state exhibit specific trajectories from the onset of the process, suggesting ‘V’-shaped model. Using these analyses, not only we could describe in detail the various trajectories toward the two states, we also identified previously unknown stage-specific reprogramming markers as well as markers for faithful reprogramming and reprogramming blockers. Finally, we show that while the acquisition of the TSC state involves the silencing of embryonic programs by DNA methylation, during the acquisition of pluripotency these specific regions are initially open but then retain inactive by the elimination of the histone mark, H3K27ac." @default.
- W3088500806 created "2020-10-01" @default.
- W3088500806 creator A5001826506 @default.
- W3088500806 creator A5002148475 @default.
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- W3088500806 creator A5014923158 @default.
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- W3088500806 creator A5048993481 @default.
- W3088500806 creator A5057994815 @default.
- W3088500806 creator A5086696743 @default.
- W3088500806 date "2020-09-28" @default.
- W3088500806 modified "2023-09-26" @default.
- W3088500806 title "Comparative Parallel Multi-Omics Analysis During the Induction of Pluripotent and Trophectoderm States" @default.
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