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- W3088567461 abstract "Abstract Widespread antibiotic usage in apiculture contributes substantially to the global dissemination of antimicrobial resistance and has the potential to negatively influence bacterial symbionts of honey bees ( Apis mellifera ). Here, we show that routine antibiotic administration with oxytetracycline selectively increased tetB (efflux pump resistance gene) abundance in the gut microbiota of adult workers while concurrently depleting several key symbionts known to regulate immune function and nutrient metabolism such as Frischella perrera and Lactobacillus Firm-5 strains. These microbial changes were functionally characterized by decreased capped brood counts (marker of hive nutritional status and productivity) and reduced antimicrobial capacity of adult hemolymph (indicator of immune competence). Importantly, combination therapy with three immunostimulatory Lactobacillus strains could mitigate antibiotic-associated microbiota dysbiosis and immune deficits in adult workers, as well as maximize the intended benefit of oxytetracycline by suppressing larval pathogen loads to near-undetectable levels. We conclude that microbial-based therapeutics may offer a simple but effective solution to reduce honey bee disease burden, environmental xenobiotic exposure, and spread of antimicrobial resistance." @default.
- W3088567461 created "2020-10-01" @default.
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- W3088567461 date "2020-09-25" @default.
- W3088567461 modified "2023-10-17" @default.
- W3088567461 title "Lactobacillus spp. attenuate antibiotic-induced immune and microbiota dysregulation in honey bees" @default.
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- W3088567461 cites W1991669423 @default.
- W3088567461 cites W1996718064 @default.
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- W3088567461 cites W2009428720 @default.
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- W3088567461 cites W2049091796 @default.
- W3088567461 cites W2051021208 @default.
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- W3088567461 cites W2078008562 @default.
- W3088567461 cites W2080936059 @default.
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- W3088567461 cites W2171654274 @default.
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- W3088567461 cites W2294922595 @default.
- W3088567461 cites W2314124873 @default.
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- W3088567461 doi "https://doi.org/10.1038/s42003-020-01259-8" @default.
- W3088567461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7519052" @default.
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- W3088567461 hasPublicationYear "2020" @default.
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