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• W3088597003 abstract "Abstract Deficits in learning and memory are often associated with disruption of hippocampal neurogenesis, which is regulated by numerous processes, including precursor cell proliferation, survival, migration, and differentiation to mature neurons. Recent studies demonstrate that adult born neurons in the dentate gyrus (DG) in the hippocampus can functionally integrate into the existing neuronal circuitry and contribute to hippocampal-dependent learning and memory. Here, we demonstrate that relatively short-term deltamethrin exposure (3 mg/kg every 3 days for 1 month) inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice. Hippocampal-dependent cognitive functions were evaluated using 2 independent hippocampal-dependent behavioral tests, the novel object recognition task and Morris water maze. We found that deltamethrin-treated mice exhibited profound deficits in novel object recognition and learning and memory in water maze. Deltamethrin exposure significantly decreased bromodeoxyuridine (BrdU)-positive cells (39%) and Ki67+ cells (47%) in the DG of the hippocampus, indicating decreased cellular proliferation. In addition, deltamethrin-treated mice exhibited a 44% decrease in nestin-expressing neural progenitor cells and a 38% reduction in the expression of doublecortin (DCX), an early neuronal differentiation marker. Furthermore, deltamethrin-exposed mice exhibited a 25% reduction in total number of granule cells in the DG. These findings indicate that relatively short-term exposure to deltamethrin causes significant deficits in hippocampal neurogenesis that is associated with impaired learning and memory." @default.
• W3088597003 created "2020-10-01" @default.
• W3088597003 creator A5014170050 @default.
• W3088597003 creator A5026746873 @default.
• W3088597003 creator A5035656932 @default.
• W3088597003 creator A5045586758 @default.
• W3088597003 date "2020-09-25" @default.
• W3088597003 modified "2023-10-12" @default.
• W3088597003 title "Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice" @default.
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• W3088597003 doi "https://doi.org/10.1093/toxsci/kfaa144" @default.
• W3088597003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7706404" @default.
• W3088597003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32976580" @default.
• W3088597003 hasPublicationYear "2020" @default.
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