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• W3088691799 abstract "Abstract Background Despite improvements in overall survival for pediatric cancers, treatment disparities remain for racial/ethnic minorities compared to non‐Hispanic Whites; however, the impact of race on treatment outcomes for pediatric brain and central nervous system (CNS) tumors in the United States is not well known. Methods We included 8713 children aged 0‐19 years with newly diagnosed primary brain and CNS tumors between 2000 and 2015 from the Census Tract‐level SES and Rurality Database developed by Surveillance, Epidemiology, and End Results (SEER) Program. We used chi‐square tests to assess differences in sociodemographic, cancer, and treatment characteristics by race/ethnicity and Kaplan‐Meier curves and Cox proportional hazards models to examine differences in 10‐year survival, adjusting for these characteristics. Results Among 8713 patients, 56.75% were non‐Hispanic White, 9.59% non‐Hispanic Black, 25.46% Hispanic, and 8.19% from “other” racial/ethnic groups. Median unadjusted survival for all pediatric brain tumors was 53 months, but varied significantly by race/ethnicity with a median survival of 62 months for non‐Hispanic Whites, 41 months for non‐Hispanic Blacks, and 40 months for Hispanic and other. Multivariable analyses demonstrated minority racial groups still had significantly higher hazard of death than non‐Hispanic Whites; Hispanic (adjusted hazard ratio [aHR] 1.25 [1.18‐1.31]); non‐Hispanic Black (aHR 1.12 [1.04‐1.21]); other (aHR 1.22 [1.12‐1.32]). Results were consistent when stratified by tumor histology. Conclusion We identified disparities in survival among racial/ethnic minorities with pediatric brain and CNS tumors, with Hispanic patients having the highest risk of mortality. Eliminating these disparities requires commitment toward promoting heath equity and personalized cancer treatment." @default.
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• W3088691799 date "2020-09-24" @default.
• W3088691799 modified "2023-10-17" @default.
• W3088691799 title "Racial and ethnic disparities in survival of children with brain and central nervous tumors in the United States" @default.
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• W3088691799 doi "https://doi.org/10.1002/pbc.28738" @default.
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