FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088702948> ?p ?o ?g. }

• W3088702948 endingPage "G684" @default.
• W3088702948 startingPage "G669" @default.
• W3088702948 abstract "Vertical sleeve gastrectomy (VSG) is the best current therapy for remission of obesity and its co-morbidities. It is understood to alter the enterohepatic circulation of bile acids in vivo. Fibroblast growth factor 19 (FGF19) in human and its murine orthologue Fgf15 plays a pivotal role in this bile acid driven enterohepatic signaling. The present study evaluated the metabolic outcomes of VSG in Fgf15 deficient mice. 6-8 weeks old male wildtype mice (WT) and Fgf15 deficient mice (KO) were fed a high fat diet (HFD) for 8 weeks. At 8th week of diet, both WT and KO mice were randomly distributed to VSG or sham surgery. Post-surgery, mice were observed for 8 weeks while fed a HFD and then euthanized to collect tissues for experimental analysis. Fgf15 deficient (KO) mice lost weight post VSG, but glucose tolerance in KO mice did not improve post VSG compared to WT mice. Enteroids derived from WT and KO mice proliferated with bile acid exposure in vitro. Post VSG both WT and KO mice had similarly altered bile acid enterohepatic flux, however Fgf15 deficient mice post VSG had increased hepatic accumulation of free and esterified cholesterol leading to lipotoxicity related ER stress, inflammasome activation, and increased Fgf21 expression. Intact Fgf15 mediated enterohepatic bile acid signaling, but not changes in bile acid flux, appear to be important for the metabolic improvements post-murine bariatric surgery. These novel data introduce a potential point of distinction between bile acids acting as ligands compared to their canonical downstream signaling pathways." @default.
• W3088702948 created "2020-10-01" @default.
• W3088702948 creator A5004357167 @default.
• W3088702948 creator A5007133063 @default.
• W3088702948 creator A5015084788 @default.
• W3088702948 creator A5017820051 @default.
• W3088702948 creator A5026932091 @default.
• W3088702948 creator A5032629734 @default.
• W3088702948 creator A5036232450 @default.
• W3088702948 creator A5036804110 @default.
• W3088702948 creator A5037850683 @default.
• W3088702948 creator A5045342696 @default.
• W3088702948 creator A5055593742 @default.
• W3088702948 creator A5065488328 @default.
• W3088702948 creator A5072532863 @default.
• W3088702948 creator A5082270295 @default.
• W3088702948 date "2020-12-01" @default.
• W3088702948 modified "2023-09-28" @default.
• W3088702948 title "Assessment of the role of FGF15 in mediating the metabolic outcomes of murine vertical sleeve gastrectomy" @default.
• W3088702948 cites W1196165627 @default.
• W3088702948 cites W1519585418 @default.
• W3088702948 cites W1639434581 @default.
• W3088702948 cites W1673746375 @default.
• W3088702948 cites W1960264345 @default.
• W3088702948 cites W1974531488 @default.
• W3088702948 cites W1975673963 @default.
• W3088702948 cites W1976348644 @default.
• W3088702948 cites W1981894899 @default.
• W3088702948 cites W1990012207 @default.
• W3088702948 cites W1993108478 @default.
• W3088702948 cites W2006024610 @default.
• W3088702948 cites W2019441910 @default.
• W3088702948 cites W2020799782 @default.
• W3088702948 cites W2037001212 @default.
• W3088702948 cites W2041451676 @default.
• W3088702948 cites W2053073281 @default.
• W3088702948 cites W2075342501 @default.
• W3088702948 cites W2075720989 @default.
• W3088702948 cites W2085897281 @default.
• W3088702948 cites W2090429237 @default.
• W3088702948 cites W2093364415 @default.
• W3088702948 cites W2094051977 @default.
• W3088702948 cites W2099579483 @default.
• W3088702948 cites W2106678312 @default.
• W3088702948 cites W2118000514 @default.
• W3088702948 cites W2119568544 @default.
• W3088702948 cites W2124025733 @default.
• W3088702948 cites W2136769963 @default.
• W3088702948 cites W2147259528 @default.
• W3088702948 cites W2154540302 @default.
• W3088702948 cites W2155956056 @default.
• W3088702948 cites W2170535838 @default.
• W3088702948 cites W2178899926 @default.
• W3088702948 cites W2186316312 @default.
• W3088702948 cites W2216199002 @default.
• W3088702948 cites W2336618255 @default.
• W3088702948 cites W2400321486 @default.
• W3088702948 cites W2441079925 @default.
• W3088702948 cites W2586579187 @default.
• W3088702948 cites W2606822819 @default.
• W3088702948 cites W2731063128 @default.
• W3088702948 cites W2735376054 @default.
• W3088702948 cites W2744749251 @default.
• W3088702948 cites W2767683865 @default.
• W3088702948 cites W2781514429 @default.
• W3088702948 cites W2781735131 @default.
• W3088702948 cites W2790254301 @default.
• W3088702948 cites W2808935287 @default.
• W3088702948 cites W2888662736 @default.
• W3088702948 cites W2902215067 @default.
• W3088702948 cites W2905419175 @default.
• W3088702948 cites W2915021799 @default.
• W3088702948 cites W3003103558 @default.
• W3088702948 cites W3004956870 @default.
• W3088702948 cites W3014272029 @default.
• W3088702948 cites W3025299221 @default.
• W3088702948 cites W3047478453 @default.
• W3088702948 doi "https://doi.org/10.1152/ajpgi.00175.2020" @default.
• W3088702948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7792670" @default.
• W3088702948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32967428" @default.
• W3088702948 hasPublicationYear "2020" @default.
• W3088702948 type Work @default.
• W3088702948 sameAs 3088702948 @default.
• W3088702948 citedByCount "9" @default.
• W3088702948 countsByYear W30887029482021 @default.
• W3088702948 countsByYear W30887029482022 @default.
• W3088702948 countsByYear W30887029482023 @default.
• W3088702948 crossrefType "journal-article" @default.
• W3088702948 hasAuthorship W3088702948A5004357167 @default.
• W3088702948 hasAuthorship W3088702948A5007133063 @default.
• W3088702948 hasAuthorship W3088702948A5015084788 @default.
• W3088702948 hasAuthorship W3088702948A5017820051 @default.
• W3088702948 hasAuthorship W3088702948A5026932091 @default.
• W3088702948 hasAuthorship W3088702948A5032629734 @default.
• W3088702948 hasAuthorship W3088702948A5036232450 @default.
• W3088702948 hasAuthorship W3088702948A5036804110 @default.
• W3088702948 hasAuthorship W3088702948A5037850683 @default.
• W3088702948 hasAuthorship W3088702948A5045342696 @default.

• next