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- W3088731243 endingPage "118472" @default.
- W3088731243 startingPage "118472" @default.
- W3088731243 abstract "Testicular torsion/detorsion (T/D) is a critical medical condition that necessitates prompt surgical intervention to avoid testicular atrophy and infertility. The use of natural compounds may protect against the associated detrimental oxidative stress and inflammatory responses. Interestingly, acetyl-11-keto-β-boswellic acid (AKBA), the main active constituent of Boswellia resin, has shown potent inhibitory effect on 5-lipoxygenase enzyme which converts arachidonic acid into inflammatory mediators. Therefore, this study was conducted to assess the protective mechanisms by which AKBA may protect against testicular T/D injury in rats.Male rats were randomly distributed into five groups: Sham, AKBA (50 mg/kg, p.o.), unilateral testicular T/D, AKBA at two dose levels (25 or 50 mg/kg for 15 successive days) followed by T/D. Histological examination and Johnsen's score were performed to assess testicular injury and perturbations in spermatogenesis. Biochemical parameters included markers of testicular function (serum testosterone), oxidant/antioxidant status (malondialdehyde, glutathione), inflammation (5-lipoxygenase, leukotriene-B4, myeloperoxidase, interleukin-1β, interleukin-6), apoptosis (Bax, Bcl2, caspase-3), DNA integrity (quantitative DNA fragmentation, DNA laddering, PARP-1), energy production (ATP), in addition to p38 MAPK and JNK protein expression.In a dose dependent manner, AKBA significantly inhibited testicular T/D-induced upregulation of 5-LOX/LTB4 and p38-MAPK/JNK/Bax pathways and their associated downstream inflammatory and apoptotic cascades. These effects were accompanied with ATP replenishment and DNA preservation, resulting ultimately in salvage of the testis.Unprecedentedly, the present mechanistic study revealed the pathways by which AKBA may inhibit testicular T/D injury and offered a novel protective approach that may attenuate the severity of this condition." @default.
- W3088731243 created "2020-10-01" @default.
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- W3088731243 date "2020-11-01" @default.
- W3088731243 modified "2023-10-18" @default.
- W3088731243 title "Acetyl-11-keto-β-boswellic acid prevents testicular torsion/detorsion injury in rats by modulating 5-LOX/LTB4 and p38-MAPK/JNK/Bax/Caspase-3 pathways" @default.
- W3088731243 cites W122300678 @default.
- W3088731243 cites W1578358292 @default.
- W3088731243 cites W1582185291 @default.
- W3088731243 cites W1906197854 @default.
- W3088731243 cites W1970552047 @default.
- W3088731243 cites W1976150153 @default.
- W3088731243 cites W1978331594 @default.
- W3088731243 cites W1982423030 @default.
- W3088731243 cites W1989970029 @default.
- W3088731243 cites W1992361007 @default.
- W3088731243 cites W1998997386 @default.
- W3088731243 cites W2000983295 @default.
- W3088731243 cites W2002052527 @default.
- W3088731243 cites W2003464077 @default.
- W3088731243 cites W2006370393 @default.
- W3088731243 cites W2013925250 @default.
- W3088731243 cites W2050357693 @default.
- W3088731243 cites W2050512725 @default.
- W3088731243 cites W2050920757 @default.
- W3088731243 cites W2053054955 @default.
- W3088731243 cites W2057316443 @default.
- W3088731243 cites W2065716130 @default.
- W3088731243 cites W2069815021 @default.
- W3088731243 cites W2073442791 @default.
- W3088731243 cites W2081452901 @default.
- W3088731243 cites W2083111365 @default.
- W3088731243 cites W2084510479 @default.
- W3088731243 cites W2085493769 @default.
- W3088731243 cites W2086062308 @default.
- W3088731243 cites W2088475923 @default.
- W3088731243 cites W2090575574 @default.
- W3088731243 cites W2107277218 @default.
- W3088731243 cites W2108035502 @default.
- W3088731243 cites W2109230097 @default.
- W3088731243 cites W2113680167 @default.
- W3088731243 cites W2122635542 @default.
- W3088731243 cites W2124393451 @default.
- W3088731243 cites W2126098517 @default.
- W3088731243 cites W2128444584 @default.
- W3088731243 cites W2129128842 @default.
- W3088731243 cites W2135410831 @default.
- W3088731243 cites W2143425888 @default.
- W3088731243 cites W2144364568 @default.
- W3088731243 cites W2145991206 @default.
- W3088731243 cites W2157777887 @default.
- W3088731243 cites W2161966760 @default.
- W3088731243 cites W2163371901 @default.
- W3088731243 cites W2168259786 @default.
- W3088731243 cites W2279591454 @default.
- W3088731243 cites W2343766127 @default.
- W3088731243 cites W2484037831 @default.
- W3088731243 cites W2517416689 @default.
- W3088731243 cites W2528851536 @default.
- W3088731243 cites W2552460648 @default.
- W3088731243 cites W2582134481 @default.
- W3088731243 cites W2772623384 @default.
- W3088731243 cites W2791083478 @default.
- W3088731243 cites W2811006156 @default.
- W3088731243 cites W2911815162 @default.
- W3088731243 cites W2915432665 @default.
- W3088731243 cites W2969126538 @default.
- W3088731243 cites W2969548222 @default.
- W3088731243 cites W2973227943 @default.
- W3088731243 cites W2981333501 @default.
- W3088731243 cites W2983785955 @default.
- W3088731243 cites W3008830538 @default.
- W3088731243 cites W3011984121 @default.
- W3088731243 cites W3020448852 @default.
- W3088731243 cites W3035895393 @default.
- W3088731243 cites W3036581898 @default.
- W3088731243 cites W4249156097 @default.
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- W3088731243 doi "https://doi.org/10.1016/j.lfs.2020.118472" @default.
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