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- W3088751004 abstract "The human skin surface serves as the interface between the environment and the rest of the body. As such, the skin provides a barrier against the penetration of environmental chemicals and provides an environment that is not amenable to the colonization and growth of most microorganisms. Yet, it does support the growth of some commensal microorganisms, which help in defending against pathogens. Other factors that influence which microorganisms can live at the skin surface include availability of nutrients and water, the presence of antimicrobial peptides and a relatively low pH. Sebaceous fatty acids can serve as a nutrient source for some microorganisms while being toxic to others. Some of the sebaceous fatty acids and free long-chain bases derived from stratum corneum ceramides have differential antimicrobial activity. Factors influencing microbial growth vary regionally. The head, neck, chest and upper back regions have abundant sebaceous glands, so these areas are oily. The antecubital fossa are moist, while most of the remaining skin surface is relatively dry and contains little sebum. The purpose of this chapter is to examine the roles of certain lipids found at the skin surface in determining the growth of bacteria and fungi." @default.
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- W3088751004 date "2020-08-14" @default.
- W3088751004 modified "2023-09-27" @default.
- W3088751004 title "Effects of Endogenous Lipids on the Skin Microbiome" @default.
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- W3088751004 doi "https://doi.org/10.1002/9781119593058.ch11" @default.
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