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• W3088755057 abstract "In the paper, a composite TiO2/SiO2-NHOC-FA was prepared using the coupling method which is a folic acid-targeted silica-coated titanium dioxide. Their structures were characterized by Fourier transform infrared spectroscopy (FT-IR), ultraviolet-visible spectroscopy (UV-vis), X-ray diffraction (XRD), transmission electron microscope (TEM) and zeta potential method. The results showed that the average diameter of the prepared TiO2/SiO2-NHOC-FA composite is 18 nm, which is spherical. Compared with unmodified TiO2, TiO2/SiO2-NHOC-FA composite had superior water solubility and dispersion, and enhanced its photokilling activity by folic acid-targeted to FR (+) cells. In addition, photocatalytic TiO2/SiO2-NHOC-FA arrested cell cycle in G2/M phase of MCF-7 cells, resulting in a significant reduction of mitochondrial membrane potential (MMP), and also made the apoptosis rate, ROS components and intracellular calcium concentration increased. It killed the MCF-7 cells through apoptosis pathway. These results for the TiO2/SiO2-NHOC-FA composite can provide a theoretical basis for the photodynamic development of TiO2." @default.
• W3088755057 created "2020-10-01" @default.
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• W3088755057 date "2020-10-20" @default.
• W3088755057 modified "2023-09-27" @default.
• W3088755057 title "TiO ₂ /SiO ₂ ‐NHOC‐FA Nanocomposite as a Photosensitizer with Targeting Ability for Photocatalytic Killing MCF‐7 Cells <i>in Vitro</i> and its Mechanism Exploration" @default.
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• W3088755057 doi "https://doi.org/10.1111/php.13336" @default.
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