Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088755065> ?p ?o ?g. }
- W3088755065 abstract "The role of CD8 + T cells in antiviral efficacy using a live-attenuated virus as the vaccine is complicated by the humoral immune response. In the case of the herpes simplex virus 1 (HSV-1) 0ΔNLS vaccine, the correlate of protection has been defined to be primarily antibody driven. The current study shows that in the near absence of anti-HSV-1 antibody, vaccinated mice are protected from subsequent challenge with wild-type HSV-1 as measured by survival. The efficacy is lost following depletion of CD8 + T cells. Whereas increased survival and reduction in virus replication were observed in vaccinated mice challenged with HSV-1, cornea pathology was mixed with a reduction in neovascularization but no change in opacity. Collectively, the study suggests CD8 + T cells significantly contribute to the host adaptive immune response to HSV-1 challenge following vaccination with an attenuated virus, but multiple factors are involved in cornea pathology in response to ocular virus challenge." @default.
- W3088755065 created "2020-10-01" @default.
- W3088755065 creator A5002276285 @default.
- W3088755065 creator A5003947838 @default.
- W3088755065 creator A5031589484 @default.
- W3088755065 creator A5037611291 @default.
- W3088755065 creator A5039181160 @default.
- W3088755065 creator A5080021282 @default.
- W3088755065 date "2020-11-23" @default.
- W3088755065 modified "2023-10-16" @default.
- W3088755065 title "Herpes Simplex Virus 1 (HSV-1) 0ΔNLS Live-Attenuated Vaccine Protects against Ocular HSV-1 Infection in the Absence of Neutralizing Antibody in HSV-1 gB T Cell Receptor-Specific Transgenic Mice" @default.
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