Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088791504> ?p ?o ?g. }
- W3088791504 endingPage "36" @default.
- W3088791504 startingPage "13" @default.
- W3088791504 abstract "Since the US FDA approval of everolimus/exemestane in July 2012, and of the first CDK 4/6 inhibitor, palbociclib, combined with endocrine treatment in February 2015, a third class of therapeutic compounds, the PI3K inhibitors, has been introduced to the arsenal of targeted therapies overcoming endocrine resistance in hormone receptor-positive metastatic breast cancer. Alpelisib (PIQRAY ® ) is the first of these novel agents yielding promising clinical results, giving an impetus to further development of tailored endocrine anticancer treatments. Herein, we review its pharmacodynamic and pharmacokinetic properties, safety and efficacy data, as well as Phase III SOLAR-1 trial, prompting FDA approval of alpelisib in hormone receptor-positive metastatic breast cancer harboring PIK3CA mutations. Furthermore, implications for clinical use and current research will also be discussed." @default.
- W3088791504 created "2020-10-01" @default.
- W3088791504 creator A5011232197 @default.
- W3088791504 creator A5069413058 @default.
- W3088791504 date "2021-01-01" @default.
- W3088791504 modified "2023-09-27" @default.
- W3088791504 title "Alpelisib in the treatment of metastatic HR+ breast cancer with <i>PIK3CA</i> mutations" @default.
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