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- W3088794119 abstract "Exhaled breath analysis has become an important part of volatilomics, with high potential for health applications, particularly as a noninvasive diagnostic tool. Nevertheless, this approach faces numerous challenges, the first being the need to employ powerful analytical techniques to properly resolve the breath volatilome and to extract the relevant information, and the second consisting of establishing a high-quality and reliable data analysis workflow. This chapter highlights the capabilities of comprehensive two-dimensional gas chromatography (GC×GC) as the ideal analytical technique for the analysis of exhaled breath. The coupling of GC×GC with mass spectrometry (MS) and the enhanced identification power using high-resolution (HR) MS is also discussed. In addition, an emphasis is placed on the importance of the data processing workflow, as well as the need to produce high data quality in order to perform useful statistical analyses. Finally, some successful applications of GC×GC-(HR)MS in volatilomics are presented." @default.
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- W3088794119 date "2020-01-01" @default.
- W3088794119 modified "2023-09-23" @default.
- W3088794119 title "Comprehensive gas chromatography-mass spectrometry" @default.
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- W3088794119 doi "https://doi.org/10.1016/b978-0-12-819967-1.00015-3" @default.
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