Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088849376> ?p ?o ?g. }
- W3088849376 endingPage "38" @default.
- W3088849376 startingPage "38" @default.
- W3088849376 abstract "Although in many ways the arterial and atrioventricular valves are similar, both being derived for the most part from endocardial cushions, we now know that the arterial valves and their surrounding structures are uniquely dependent on progenitors from both the second heart field (SHF) and neural crest cells (NCC). Here, we will review aspects of arterial valve development, highlighting how our appreciation of NCC and the discovery of the SHF have altered our developmental models. We will highlight areas of research that have been particularly instructive for understanding how the leaflets form and remodel, as well as those with limited or conflicting results. With this background, we will explore how this developmental knowledge can help us to understand human valve malformations, particularly those of the bicuspid aortic valve (BAV). Controversies and the current state of valve genomics will be indicated." @default.
- W3088849376 created "2020-10-01" @default.
- W3088849376 creator A5009711858 @default.
- W3088849376 creator A5019452889 @default.
- W3088849376 creator A5067583640 @default.
- W3088849376 date "2020-09-24" @default.
- W3088849376 modified "2023-10-16" @default.
- W3088849376 title "New Concepts in the Development and Malformation of the Arterial Valves" @default.
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