Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088890625> ?p ?o ?g. }
- W3088890625 endingPage "4824" @default.
- W3088890625 startingPage "4808" @default.
- W3088890625 abstract "Filamentous fungi are known as producers of a large array of diverse secondary metabolites (SMs) that aid in securing their environmental niche. Here, we demonstrated that the SMs have an additional role in fungal defence against other fungi: Trichoderma guizhouense, a mycoparasite, is able to antagonize Fusarium oxysporum f. sp. cubense race 4 (Foc4) by forming aerial hyphae that kill the host with hydrogen peroxide. At the same time, a gene cluster comprising two polyketide synthases is strongly expressed. Using functional genetics, we characterized this cluster and identified its products as azaphilones (termed as trigazaphilones). The trigazaphilones were found lacking of antifungal toxicity but exhibited high radical scavenging activities. The antioxidant property of trigazaphilones was in vivo functional under various tested conditions of oxidative stress. Thus, we conclude that the biosynthesis of trigazaphilones serves as a complementary antioxidant mechanism and defends T. guizhouense against the hydrogen peroxide that it produces to combat other fungi like Foc4." @default.
- W3088890625 created "2020-10-01" @default.
- W3088890625 creator A5001986694 @default.
- W3088890625 creator A5014265938 @default.
- W3088890625 creator A5047129098 @default.
- W3088890625 creator A5051064175 @default.
- W3088890625 creator A5055422679 @default.
- W3088890625 creator A5058119738 @default.
- W3088890625 creator A5065784569 @default.
- W3088890625 creator A5067482090 @default.
- W3088890625 creator A5071037763 @default.
- W3088890625 creator A5073288256 @default.
- W3088890625 creator A5082789096 @default.
- W3088890625 date "2020-10-19" @default.
- W3088890625 modified "2023-10-18" @default.
- W3088890625 title "Azaphilones biosynthesis complements the defence mechanism of<i>Trichoderma guizhouense</i>against oxidative stress" @default.
- W3088890625 cites W1716977868 @default.
- W3088890625 cites W1874751834 @default.
- W3088890625 cites W1981340668 @default.
- W3088890625 cites W1991415074 @default.
- W3088890625 cites W1992534722 @default.
- W3088890625 cites W1996478236 @default.
- W3088890625 cites W2005284935 @default.
- W3088890625 cites W2007871704 @default.
- W3088890625 cites W2012031934 @default.
- W3088890625 cites W2027950358 @default.
- W3088890625 cites W2030452223 @default.
- W3088890625 cites W2031290750 @default.
- W3088890625 cites W2037098859 @default.
- W3088890625 cites W2037590349 @default.
- W3088890625 cites W2041695279 @default.
- W3088890625 cites W2042230847 @default.
- W3088890625 cites W2047751512 @default.
- W3088890625 cites W2065705176 @default.
- W3088890625 cites W2066650452 @default.
- W3088890625 cites W2075931929 @default.
- W3088890625 cites W2075934694 @default.
- W3088890625 cites W2077692316 @default.
- W3088890625 cites W2080562780 @default.
- W3088890625 cites W2085128107 @default.
- W3088890625 cites W2085729776 @default.
- W3088890625 cites W2086953382 @default.
- W3088890625 cites W2093022166 @default.
- W3088890625 cites W2093386502 @default.
- W3088890625 cites W2096086497 @default.
- W3088890625 cites W2096539633 @default.
- W3088890625 cites W2102112528 @default.
- W3088890625 cites W2102187892 @default.
- W3088890625 cites W2102884248 @default.
- W3088890625 cites W2125006413 @default.
- W3088890625 cites W2130391796 @default.
- W3088890625 cites W2134526812 @default.
- W3088890625 cites W2140289048 @default.
- W3088890625 cites W2140729960 @default.
- W3088890625 cites W2142678478 @default.
- W3088890625 cites W2152901676 @default.
- W3088890625 cites W2154434069 @default.
- W3088890625 cites W2168039886 @default.
- W3088890625 cites W2179438025 @default.
- W3088890625 cites W2203188126 @default.
- W3088890625 cites W2219528370 @default.
- W3088890625 cites W2333495309 @default.
- W3088890625 cites W2515963470 @default.
- W3088890625 cites W2528268253 @default.
- W3088890625 cites W2560007809 @default.
- W3088890625 cites W2604788465 @default.
- W3088890625 cites W2612368764 @default.
- W3088890625 cites W2625789352 @default.
- W3088890625 cites W2744648810 @default.
- W3088890625 cites W2748841886 @default.
- W3088890625 cites W2766415509 @default.
- W3088890625 cites W2766673856 @default.
- W3088890625 cites W2770086183 @default.
- W3088890625 cites W2797548348 @default.
- W3088890625 cites W2801935047 @default.
- W3088890625 cites W2805387924 @default.
- W3088890625 cites W2889174610 @default.
- W3088890625 cites W2892209988 @default.
- W3088890625 cites W2905340019 @default.
- W3088890625 cites W2918473335 @default.
- W3088890625 cites W2947907527 @default.
- W3088890625 cites W2949926205 @default.
- W3088890625 cites W3008343690 @default.
- W3088890625 cites W4210971654 @default.
- W3088890625 doi "https://doi.org/10.1111/1462-2920.15246" @default.
- W3088890625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32985773" @default.
- W3088890625 hasPublicationYear "2020" @default.
- W3088890625 type Work @default.
- W3088890625 sameAs 3088890625 @default.
- W3088890625 citedByCount "22" @default.
- W3088890625 countsByYear W30888906252021 @default.
- W3088890625 countsByYear W30888906252022 @default.
- W3088890625 countsByYear W30888906252023 @default.
- W3088890625 crossrefType "journal-article" @default.
- W3088890625 hasAuthorship W3088890625A5001986694 @default.
- W3088890625 hasAuthorship W3088890625A5014265938 @default.
- W3088890625 hasAuthorship W3088890625A5047129098 @default.
- W3088890625 hasAuthorship W3088890625A5051064175 @default.