Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088891096> ?p ?o ?g. }
- W3088891096 abstract "Abstract Cataract is the leading cause of blindness worldwide but the mechanisms involved in the process of cataractogenesis are not yet fully understood. Two most prevalent types of age-related cataracts are nuclear (N) and cortical (C) cataracts. A common environmental factor in most age-related cataracts is believed to be oxidative stress. The lens epithelium, the first physical and biological barrier in the lens, is build from lens epithelial cells (LECs). LECs are important for the maintenance of lens transparency as they control energy production, antioxidative mechanisms and biochemical transport for the whole lens. The purpose of this study is to characterize compounds in LECs originated from N and C cataracts, by using the synchrotron radiation-based Fourier Transform Infrared (SR-FTIR) microspectroscopy, in order to understand the functional importance of their different bio-macromolecules in cataractogenesis. We used the SR-FTIR microspectroscopy setup installed on the beamline MIRAS at the Spanish synchrotron light source ALBA, where measurements were set to achieve single cell resolution, with high spectral stability and high photon flux. The results showed that protein aggregation in form of fibrils was notably pronounced in LECs of N cataracts, while oxidative stress and the lipids peroxidation were more pronounced in LECs of C cataracts." @default.
- W3088891096 created "2020-10-01" @default.
- W3088891096 creator A5021456348 @default.
- W3088891096 creator A5038078599 @default.
- W3088891096 creator A5067292602 @default.
- W3088891096 creator A5084789960 @default.
- W3088891096 date "2020-09-23" @default.
- W3088891096 modified "2023-10-16" @default.
- W3088891096 title "Synchrotron-based FTIR microspectroscopy of protein aggregation and lipids peroxidation changes in human cataractous lens epithelial cells" @default.
- W3088891096 cites W103276529 @default.
- W3088891096 cites W1490901971 @default.
- W3088891096 cites W1587493794 @default.
- W3088891096 cites W1836235076 @default.
- W3088891096 cites W1905585974 @default.
- W3088891096 cites W1965606451 @default.
- W3088891096 cites W1965884942 @default.
- W3088891096 cites W1969311287 @default.
- W3088891096 cites W1972979922 @default.
- W3088891096 cites W1973637306 @default.
- W3088891096 cites W1977603207 @default.
- W3088891096 cites W1977982633 @default.
- W3088891096 cites W1978189435 @default.
- W3088891096 cites W1981561418 @default.
- W3088891096 cites W1981768098 @default.
- W3088891096 cites W1992592342 @default.
- W3088891096 cites W1998452269 @default.
- W3088891096 cites W2002685197 @default.
- W3088891096 cites W2003602439 @default.
- W3088891096 cites W2004329409 @default.
- W3088891096 cites W2009453323 @default.
- W3088891096 cites W2013947447 @default.
- W3088891096 cites W2019525505 @default.
- W3088891096 cites W2023791147 @default.
- W3088891096 cites W2031277180 @default.
- W3088891096 cites W2046658835 @default.
- W3088891096 cites W2055962869 @default.
- W3088891096 cites W2057727470 @default.
- W3088891096 cites W2059866896 @default.
- W3088891096 cites W2062099284 @default.
- W3088891096 cites W2062918974 @default.
- W3088891096 cites W2063898283 @default.
- W3088891096 cites W2064488444 @default.
- W3088891096 cites W2069869463 @default.
- W3088891096 cites W2080093415 @default.
- W3088891096 cites W2082937294 @default.
- W3088891096 cites W2084257551 @default.
- W3088891096 cites W2085183163 @default.
- W3088891096 cites W2088450115 @default.
- W3088891096 cites W2088622060 @default.
- W3088891096 cites W2090556647 @default.
- W3088891096 cites W2091281063 @default.
- W3088891096 cites W2096623583 @default.
- W3088891096 cites W2104092324 @default.
- W3088891096 cites W2107358135 @default.
- W3088891096 cites W2112286580 @default.
- W3088891096 cites W2112768176 @default.
- W3088891096 cites W2119930812 @default.
- W3088891096 cites W2120120479 @default.
- W3088891096 cites W2138001356 @default.
- W3088891096 cites W2160829101 @default.
- W3088891096 cites W2169789165 @default.
- W3088891096 cites W2181969137 @default.
- W3088891096 cites W2190250344 @default.
- W3088891096 cites W2294831281 @default.
- W3088891096 cites W2317877264 @default.
- W3088891096 cites W2397290649 @default.
- W3088891096 cites W2463078151 @default.
- W3088891096 cites W2506615356 @default.
- W3088891096 cites W2729695533 @default.
- W3088891096 cites W2738017457 @default.
- W3088891096 cites W2739624893 @default.
- W3088891096 cites W2740742697 @default.
- W3088891096 cites W2765572660 @default.
- W3088891096 cites W2773975300 @default.
- W3088891096 cites W2906623936 @default.
- W3088891096 cites W2942754201 @default.
- W3088891096 cites W2950510535 @default.
- W3088891096 cites W4210308942 @default.
- W3088891096 cites W592395365 @default.
- W3088891096 doi "https://doi.org/10.1038/s41598-020-72413-9" @default.
- W3088891096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7511928" @default.
- W3088891096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32968091" @default.
- W3088891096 hasPublicationYear "2020" @default.
- W3088891096 type Work @default.
- W3088891096 sameAs 3088891096 @default.
- W3088891096 citedByCount "12" @default.
- W3088891096 countsByYear W30888910962021 @default.
- W3088891096 countsByYear W30888910962022 @default.
- W3088891096 countsByYear W30888910962023 @default.
- W3088891096 crossrefType "journal-article" @default.
- W3088891096 hasAuthorship W3088891096A5021456348 @default.
- W3088891096 hasAuthorship W3088891096A5038078599 @default.
- W3088891096 hasAuthorship W3088891096A5067292602 @default.
- W3088891096 hasAuthorship W3088891096A5084789960 @default.
- W3088891096 hasBestOaLocation W30888910961 @default.
- W3088891096 hasConcept C120665830 @default.
- W3088891096 hasConcept C121332964 @default.
- W3088891096 hasConcept C12554922 @default.
- W3088891096 hasConcept C15336307 @default.
- W3088891096 hasConcept C160892712 @default.