FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088894775> ?p ?o ?g. }

• W3088894775 endingPage "6954" @default.
• W3088894775 startingPage "6954" @default.
• W3088894775 abstract "Previously, we reported that phospholipase D1 (PLD1) and PLD2 inhibition by selective PLD1 and PLD2 inhibitors could prevent platelet aggregation in humans, but not in mice. Moreover, only the PLD1 inhibitor, but not PLD2 inhibitor, could effectively prevent thrombus formation in mice, indicating that PLD might play different roles in platelet function in humans and mice. Although PLD1 and PLD2 were reported to be implicated in thrombotic events, the role of PLD in mice remains not completely clear. Here, we investigated the role of PLD1 and PLD2 in acute pulmonary thrombosis and transient middle cerebral artery occlusion-induced brain injury in mice. The data revealed that inhibition of PLD1, but not of PLD2, could partially prevent pulmonary thrombosis-induced death. Moreover, concurrent PLD1 and PLD2 inhibition could considerably increase survival rate. Likewise, inhibition of PLD1, but not PLD2, partially improved ischemic stroke and concurrent inhibition of PLD1, and PLD2 exhibited a relatively better protection against ischemic stroke, as evidenced by the infarct size, brain edema, modified neurological severity score, rotarod test, and the open field test. In conclusion, PLD1 might play a more important role than PLD2, and both PLD1 and PLD2 could act synergistically or have partially redundant functions in regulating thrombosis-relevant events." @default.
• W3088894775 created "2020-10-01" @default.
• W3088894775 creator A5001077780 @default.
• W3088894775 creator A5014766784 @default.
• W3088894775 creator A5020877227 @default.
• W3088894775 creator A5025047436 @default.
• W3088894775 creator A5031803820 @default.
• W3088894775 creator A5039884530 @default.
• W3088894775 creator A5056401612 @default.
• W3088894775 creator A5084877136 @default.
• W3088894775 date "2020-09-22" @default.
• W3088894775 modified "2023-10-16" @default.
• W3088894775 title "Phospholipase D1 and D2 Synergistically Regulate Thrombus Formation" @default.
• W3088894775 cites W1953933918 @default.
• W3088894775 cites W1974823287 @default.
• W3088894775 cites W1993159760 @default.
• W3088894775 cites W2002729523 @default.
• W3088894775 cites W2036636564 @default.
• W3088894775 cites W2059159442 @default.
• W3088894775 cites W2076225033 @default.
• W3088894775 cites W2100876024 @default.
• W3088894775 cites W2109963121 @default.
• W3088894775 cites W2121836743 @default.
• W3088894775 cites W2129303232 @default.
• W3088894775 cites W2139464903 @default.
• W3088894775 cites W2143976331 @default.
• W3088894775 cites W2166535571 @default.
• W3088894775 cites W2173000237 @default.
• W3088894775 cites W2284815995 @default.
• W3088894775 cites W2526234767 @default.
• W3088894775 cites W2586545515 @default.
• W3088894775 cites W2640007748 @default.
• W3088894775 cites W2734391791 @default.
• W3088894775 cites W2735213051 @default.
• W3088894775 cites W2759690718 @default.
• W3088894775 cites W2782280176 @default.
• W3088894775 cites W2810886674 @default.
• W3088894775 cites W2901852085 @default.
• W3088894775 cites W2912600388 @default.
• W3088894775 cites W2949669634 @default.
• W3088894775 cites W2958279669 @default.
• W3088894775 cites W2978179839 @default.
• W3088894775 cites W3012612161 @default.
• W3088894775 cites W4233431234 @default.
• W3088894775 doi "https://doi.org/10.3390/ijms21186954" @default.
• W3088894775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7555624" @default.
• W3088894775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32971863" @default.
• W3088894775 hasPublicationYear "2020" @default.
• W3088894775 type Work @default.
• W3088894775 sameAs 3088894775 @default.
• W3088894775 citedByCount "2" @default.
• W3088894775 countsByYear W30888947752023 @default.
• W3088894775 crossrefType "journal-article" @default.
• W3088894775 hasAuthorship W3088894775A5001077780 @default.
• W3088894775 hasAuthorship W3088894775A5014766784 @default.
• W3088894775 hasAuthorship W3088894775A5020877227 @default.
• W3088894775 hasAuthorship W3088894775A5025047436 @default.
• W3088894775 hasAuthorship W3088894775A5031803820 @default.
• W3088894775 hasAuthorship W3088894775A5039884530 @default.
• W3088894775 hasAuthorship W3088894775A5056401612 @default.
• W3088894775 hasAuthorship W3088894775A5084877136 @default.
• W3088894775 hasBestOaLocation W30888947751 @default.
• W3088894775 hasConcept C126322002 @default.
• W3088894775 hasConcept C180373561 @default.
• W3088894775 hasConcept C185592680 @default.
• W3088894775 hasConcept C2776330855 @default.
• W3088894775 hasConcept C2778918659 @default.
• W3088894775 hasConcept C2780868729 @default.
• W3088894775 hasConcept C2781362458 @default.
• W3088894775 hasConcept C41625074 @default.
• W3088894775 hasConcept C541997718 @default.
• W3088894775 hasConcept C55493867 @default.
• W3088894775 hasConcept C6182249 @default.
• W3088894775 hasConcept C62478195 @default.
• W3088894775 hasConcept C71924100 @default.
• W3088894775 hasConcept C98274493 @default.
• W3088894775 hasConceptScore W3088894775C126322002 @default.
• W3088894775 hasConceptScore W3088894775C180373561 @default.
• W3088894775 hasConceptScore W3088894775C185592680 @default.
• W3088894775 hasConceptScore W3088894775C2776330855 @default.
• W3088894775 hasConceptScore W3088894775C2778918659 @default.
• W3088894775 hasConceptScore W3088894775C2780868729 @default.
• W3088894775 hasConceptScore W3088894775C2781362458 @default.
• W3088894775 hasConceptScore W3088894775C41625074 @default.
• W3088894775 hasConceptScore W3088894775C541997718 @default.
• W3088894775 hasConceptScore W3088894775C55493867 @default.
• W3088894775 hasConceptScore W3088894775C6182249 @default.
• W3088894775 hasConceptScore W3088894775C62478195 @default.
• W3088894775 hasConceptScore W3088894775C71924100 @default.
• W3088894775 hasConceptScore W3088894775C98274493 @default.
• W3088894775 hasFunder F4320322795 @default.
• W3088894775 hasFunder F4320328667 @default.
• W3088894775 hasFunder F4320335511 @default.
• W3088894775 hasIssue "18" @default.
• W3088894775 hasLocation W30888947751 @default.
• W3088894775 hasLocation W30888947752 @default.
• W3088894775 hasOpenAccess W3088894775 @default.
• W3088894775 hasPrimaryLocation W30888947751 @default.

• next