Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088973344> ?p ?o ?g. }
- W3088973344 abstract "APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element mediates repression in normal cells and that expression is activated by its mutational disruption in a reporter construct or the endogenous A3B gene. The same E2F site is required for A3B induction by polyomavirus T antigen indicating a shared molecular mechanism. Proteomic and biochemical experiments demonstrate the binding of wildtype but not mutant E2F promoters by repressive PRC1.6/E2F6 and DREAM/E2F4 complexes. Knockdown and overexpression studies confirm the involvement of these repressive complexes in regulating A3B expression. Altogether, these studies demonstrate that A3B expression is suppressed in normal cells by repressive E2F complexes and that viral or mutational disruption of this regulatory network triggers overexpression in breast cancer and provides fuel for tumor evolution." @default.
- W3088973344 created "2020-10-01" @default.
- W3088973344 creator A5006387610 @default.
- W3088973344 creator A5015869890 @default.
- W3088973344 creator A5029415709 @default.
- W3088973344 creator A5034479642 @default.
- W3088973344 creator A5035901749 @default.
- W3088973344 creator A5036543476 @default.
- W3088973344 creator A5047043133 @default.
- W3088973344 creator A5051277779 @default.
- W3088973344 creator A5066926133 @default.
- W3088973344 creator A5069921086 @default.
- W3088973344 creator A5080092101 @default.
- W3088973344 creator A5090664851 @default.
- W3088973344 date "2020-09-28" @default.
- W3088973344 modified "2023-10-12" @default.
- W3088973344 title "Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B" @default.
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