Matches in SemOpenAlex for { <https://semopenalex.org/work/W3088981068> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3088981068 abstract "Abstract In the pharmaceutical industry, the goal of a supply planner is to make efficient capacity allocation decisions that ensure an uninterrupted supply of drug products to patients and to maintain product inventory levels close to the target stock. This task can be challenging due to the limited availability of manufacturing assets, uncertainties in product demand, fluctuations in production yields, and unplanned site downtimes. It is not uncommon to observe uneven distribution of product inventories with some products carrying excess inventories, while other products may be close to a stockout. Maintaining high stock levels can have economic repercussions due to the risk of expiration of unused products (whereas products facing a stockout can adversely affect the treatment regimen of patients). The network complexity of pharmaceutical supply‐chains coupled with regulatory constraints and siloed planning systems force supply planners to rely on manual (error‐prone) decision‐making processes. Such an approach results in suboptimal capacity allocation and inventory management decisions. In this work, we propose a stochastic optimization methodology for the production scheduling of multiple drug products in lyophilization units across multiple sites. The framework leverages information obtained from historical and forecast data to generate scenarios of uncertain parameters (e.g., yield, demand, and downtimes) that can realize in the future. The optimization model determines a product filling schedule that maintains product stock levels close to targets under diverse scenarios. We show that this approach helps in avoiding reactive scheduling and in maintaining a more robust production plan than deterministic procedures (which ignore uncertainty). Specifically, planning under a stochastic optimization approach reduces the number of scenarios under which backlogs are observed and also reduces the magnitude of the backlogs." @default.
- W3088981068 created "2020-10-01" @default.
- W3088981068 creator A5022395260 @default.
- W3088981068 creator A5041496613 @default.
- W3088981068 creator A5044340533 @default.
- W3088981068 creator A5051795949 @default.
- W3088981068 creator A5083590669 @default.
- W3088981068 creator A5088533442 @default.
- W3088981068 date "2020-10-07" @default.
- W3088981068 modified "2023-09-27" @default.
- W3088981068 title "<scp>Multisite</scp> supply planning for drug products under uncertainty" @default.
- W3088981068 cites W1569990960 @default.
- W3088981068 cites W1978627504 @default.
- W3088981068 cites W1990298160 @default.
- W3088981068 cites W2003826886 @default.
- W3088981068 cites W2008174835 @default.
- W3088981068 cites W2046278684 @default.
- W3088981068 cites W2070558838 @default.
- W3088981068 cites W2089299191 @default.
- W3088981068 cites W2105747197 @default.
- W3088981068 cites W2117942656 @default.
- W3088981068 cites W2131721561 @default.
- W3088981068 cites W2137527671 @default.
- W3088981068 cites W2167816741 @default.
- W3088981068 cites W2524435985 @default.
- W3088981068 cites W2601560242 @default.
- W3088981068 cites W2895048157 @default.
- W3088981068 cites W3105558219 @default.
- W3088981068 cites W4247809614 @default.
- W3088981068 cites W53038206 @default.
- W3088981068 cites W622935592 @default.
- W3088981068 doi "https://doi.org/10.1002/aic.17069" @default.
- W3088981068 hasPublicationYear "2020" @default.
- W3088981068 type Work @default.
- W3088981068 sameAs 3088981068 @default.
- W3088981068 citedByCount "2" @default.
- W3088981068 countsByYear W30889810682022 @default.
- W3088981068 countsByYear W30889810682023 @default.
- W3088981068 crossrefType "journal-article" @default.
- W3088981068 hasAuthorship W3088981068A5022395260 @default.
- W3088981068 hasAuthorship W3088981068A5041496613 @default.
- W3088981068 hasAuthorship W3088981068A5044340533 @default.
- W3088981068 hasAuthorship W3088981068A5051795949 @default.
- W3088981068 hasAuthorship W3088981068A5083590669 @default.
- W3088981068 hasAuthorship W3088981068A5088533442 @default.
- W3088981068 hasConcept C108713360 @default.
- W3088981068 hasConcept C127413603 @default.
- W3088981068 hasConcept C144133560 @default.
- W3088981068 hasConcept C162324750 @default.
- W3088981068 hasConcept C162853370 @default.
- W3088981068 hasConcept C175444787 @default.
- W3088981068 hasConcept C204036174 @default.
- W3088981068 hasConcept C206729178 @default.
- W3088981068 hasConcept C21547014 @default.
- W3088981068 hasConcept C2778348673 @default.
- W3088981068 hasConcept C2779466795 @default.
- W3088981068 hasConcept C2781437837 @default.
- W3088981068 hasConcept C41008148 @default.
- W3088981068 hasConcept C42475967 @default.
- W3088981068 hasConcept C50601946 @default.
- W3088981068 hasConcept C78519656 @default.
- W3088981068 hasConceptScore W3088981068C108713360 @default.
- W3088981068 hasConceptScore W3088981068C127413603 @default.
- W3088981068 hasConceptScore W3088981068C144133560 @default.
- W3088981068 hasConceptScore W3088981068C162324750 @default.
- W3088981068 hasConceptScore W3088981068C162853370 @default.
- W3088981068 hasConceptScore W3088981068C175444787 @default.
- W3088981068 hasConceptScore W3088981068C204036174 @default.
- W3088981068 hasConceptScore W3088981068C206729178 @default.
- W3088981068 hasConceptScore W3088981068C21547014 @default.
- W3088981068 hasConceptScore W3088981068C2778348673 @default.
- W3088981068 hasConceptScore W3088981068C2779466795 @default.
- W3088981068 hasConceptScore W3088981068C2781437837 @default.
- W3088981068 hasConceptScore W3088981068C41008148 @default.
- W3088981068 hasConceptScore W3088981068C42475967 @default.
- W3088981068 hasConceptScore W3088981068C50601946 @default.
- W3088981068 hasConceptScore W3088981068C78519656 @default.
- W3088981068 hasFunder F4320309434 @default.
- W3088981068 hasIssue "1" @default.
- W3088981068 hasLocation W30889810681 @default.
- W3088981068 hasOpenAccess W3088981068 @default.
- W3088981068 hasPrimaryLocation W30889810681 @default.
- W3088981068 hasRelatedWork W1999562876 @default.
- W3088981068 hasRelatedWork W2030344726 @default.
- W3088981068 hasRelatedWork W2035436004 @default.
- W3088981068 hasRelatedWork W2075645477 @default.
- W3088981068 hasRelatedWork W2366270662 @default.
- W3088981068 hasRelatedWork W2369719022 @default.
- W3088981068 hasRelatedWork W2370499816 @default.
- W3088981068 hasRelatedWork W2527824939 @default.
- W3088981068 hasRelatedWork W2751749905 @default.
- W3088981068 hasRelatedWork W2973840889 @default.
- W3088981068 hasVolume "67" @default.
- W3088981068 isParatext "false" @default.
- W3088981068 isRetracted "false" @default.
- W3088981068 magId "3088981068" @default.
- W3088981068 workType "article" @default.