Matches in SemOpenAlex for { <https://semopenalex.org/work/W3089018088> ?p ?o ?g. }
- W3089018088 endingPage "666" @default.
- W3089018088 startingPage "666" @default.
- W3089018088 abstract "Background: Neuroinvasion of severe acute respiratory syndrome coronavirus (SARS-CoV) is well documented and, given the similarities between this virus and SARS-CoV-2, it seems that the neurological impairment that is associated with coronavirus disease 2019 (COVID-19) is due to SARS-CoV-2 neuroinvasion. Hypothalamic circuits are exposed to the entry of the virus via the olfactory bulb and interact centrally with crucial respiratory nuclei. Hypothalamic microRNAs are considered as potential biomarkers and modulators for various diseases and future therapeutic targets. The present study aims to investigate the microRNAs that regulate the expression of hypothalamic angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2), essential elements for SARS-CoV-2 cell entry. Methods: To determine potential hypothalamic miRNAs that can directly bind to ACE2 and TMPRSS2, multiple target bioinformatics prediction algorithms were used, including miRBase, Target scan, and miRWalk2.029. Results: Our in silico analysis has revealed that, although there are over 5000 hypothalamic miRNAs, around 31 miRNAs and 29 miRNAs have shown binding sites and strong binding capacity against ACE2 and TMPRSS2, respectively. Conclusion: These novel potential hypothalamic miRNAs can be used to identify new therapeutic targets to treat neurological symptoms in COVID-19 patients via regulation of ACE2 and TMPRSS2 expression." @default.
- W3089018088 created "2020-10-01" @default.
- W3089018088 creator A5037599520 @default.
- W3089018088 creator A5083665406 @default.
- W3089018088 date "2020-09-25" @default.
- W3089018088 modified "2023-09-25" @default.
- W3089018088 title "Identification of Novel Hypothalamic MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating ACE2 and TMPRSS2 Expression: An In Silico Analysis" @default.
- W3089018088 cites W1902711869 @default.
- W3089018088 cites W1967108854 @default.
- W3089018088 cites W1980535438 @default.
- W3089018088 cites W1995420096 @default.
- W3089018088 cites W2006811465 @default.
- W3089018088 cites W2007431542 @default.
- W3089018088 cites W2018804632 @default.
- W3089018088 cites W2038622868 @default.
- W3089018088 cites W2038886521 @default.
- W3089018088 cites W2044194362 @default.
- W3089018088 cites W2047034783 @default.
- W3089018088 cites W2050315511 @default.
- W3089018088 cites W2052344303 @default.
- W3089018088 cites W2059310361 @default.
- W3089018088 cites W2069104535 @default.
- W3089018088 cites W2088422918 @default.
- W3089018088 cites W2090262808 @default.
- W3089018088 cites W2096304780 @default.
- W3089018088 cites W2099045066 @default.
- W3089018088 cites W2101506295 @default.
- W3089018088 cites W2105349784 @default.
- W3089018088 cites W2114927764 @default.
- W3089018088 cites W2134962895 @default.
- W3089018088 cites W2142166133 @default.
- W3089018088 cites W2154241726 @default.
- W3089018088 cites W2163267648 @default.
- W3089018088 cites W2168096488 @default.
- W3089018088 cites W2169170566 @default.
- W3089018088 cites W2332534179 @default.
- W3089018088 cites W2419634259 @default.
- W3089018088 cites W2563350820 @default.
- W3089018088 cites W2607554098 @default.
- W3089018088 cites W2630192492 @default.
- W3089018088 cites W2733455360 @default.
- W3089018088 cites W2759870787 @default.
- W3089018088 cites W2790423210 @default.
- W3089018088 cites W2791796044 @default.
- W3089018088 cites W2802190043 @default.
- W3089018088 cites W2810434544 @default.
- W3089018088 cites W2898372989 @default.
- W3089018088 cites W2909133664 @default.
- W3089018088 cites W2910118871 @default.
- W3089018088 cites W2911237698 @default.
- W3089018088 cites W2944662736 @default.
- W3089018088 cites W2947478096 @default.
- W3089018088 cites W2949123173 @default.
- W3089018088 cites W2950036445 @default.
- W3089018088 cites W2973008776 @default.
- W3089018088 cites W2988479961 @default.
- W3089018088 cites W3003592770 @default.
- W3089018088 cites W3007201727 @default.
- W3089018088 cites W3009912996 @default.
- W3089018088 cites W3010168113 @default.
- W3089018088 cites W3011147220 @default.
- W3089018088 cites W3013270768 @default.
- W3089018088 cites W3013800395 @default.
- W3089018088 cites W3015925195 @default.
- W3089018088 cites W3016069520 @default.
- W3089018088 cites W3016127017 @default.
- W3089018088 cites W3016789362 @default.
- W3089018088 cites W3024635505 @default.
- W3089018088 cites W3037112120 @default.
- W3089018088 cites W3038763998 @default.
- W3089018088 cites W3040654796 @default.
- W3089018088 cites W3040831862 @default.
- W3089018088 cites W3041266812 @default.
- W3089018088 cites W3042862995 @default.
- W3089018088 cites W3046359203 @default.
- W3089018088 cites W3100078631 @default.
- W3089018088 cites W4246902513 @default.
- W3089018088 cites W4381465363 @default.
- W3089018088 doi "https://doi.org/10.3390/brainsci10100666" @default.
- W3089018088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7601472" @default.
- W3089018088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32992681" @default.
- W3089018088 hasPublicationYear "2020" @default.
- W3089018088 type Work @default.
- W3089018088 sameAs 3089018088 @default.
- W3089018088 citedByCount "31" @default.
- W3089018088 countsByYear W30890180882020 @default.
- W3089018088 countsByYear W30890180882021 @default.
- W3089018088 countsByYear W30890180882022 @default.
- W3089018088 countsByYear W30890180882023 @default.
- W3089018088 crossrefType "journal-article" @default.
- W3089018088 hasAuthorship W3089018088A5037599520 @default.
- W3089018088 hasAuthorship W3089018088A5083665406 @default.
- W3089018088 hasBestOaLocation W30890180881 @default.
- W3089018088 hasConcept C104317684 @default.
- W3089018088 hasConcept C126322002 @default.
- W3089018088 hasConcept C145059251 @default.
- W3089018088 hasConcept C159047783 @default.
- W3089018088 hasConcept C2522874641 @default.